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Dolk dolichol kinase [ Mus musculus (house mouse) ]

Gene ID: 227697, updated on 18-Apr-2024

Summary

Official Symbol
Dolkprovided by MGI
Official Full Name
dolichol kinaseprovided by MGI
Primary source
MGI:MGI:2677836
See related
Ensembl:ENSMUSG00000075419 AllianceGenome:MGI:2677836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem15; mKIAA1094
Summary
Predicted to enable dolichol kinase activity. Predicted to be involved in dolichyl monophosphate biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Im. Orthologous to human DOLK (dolichol kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
2 B; 2 21.49 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30174241..30176366, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30284229..30286354, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7804 Neighboring gene STARR-seq mESC enhancer starr_04091 Neighboring gene leucine rich repeat containing 8A VRAC subunit A Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E7805 Neighboring gene nucleoporin 188 Neighboring gene predicted gene, 39780 Neighboring gene SH3-domain GRB2-like endophilin B2

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC36683

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dolichol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dolichol kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in dolichyl monophosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dolichyl monophosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dolichol kinase
Names
transmembrane protein 15
NP_808316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177648.3NP_808316.1  dolichol kinase

    See identical proteins and their annotated locations for NP_808316.1

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Consensus CDS
    CCDS15877.1
    UniProtKB/Swiss-Prot
    Q8R2Y3
    Related
    ENSMUSP00000097792.4, ENSMUST00000100219.5
    Conserved Domains (1) summary
    cl21502
    Location:331520
    CTP_transf_1; Cytidylyltransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30174241..30176366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)