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    Fcho2 FCH domain only 2 [ Mus musculus (house mouse) ]

    Gene ID: 218503, updated on 12-Aug-2018

    Summary

    Official Symbol
    Fcho2provided by MGI
    Official Full Name
    FCH domain only 2provided by MGI
    Primary source
    MGI:MGI:3505790
    See related
    Ensembl:ENSMUSG00000041685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA387320; 5832424M12Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 10.4), placenta adult (RPKM 8.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Fcho2 in Genome Data Viewer
    Location:
    13; 13 D1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (98723406..98815768, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (99493361..99585404, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 171 Neighboring gene predicted gene 9465 Neighboring gene predicted gene, 34995 Neighboring gene ribosomal protein S17 pseudogene Neighboring gene transportin 1 Neighboring gene predicted gene 5453

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytoskeletal protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    membrane invagination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic vesicle endocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT colocalizes_with clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    F-BAR domain only protein 2
    Names
    FCH domain only protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172591.3NP_766179.2  F-BAR domain only protein 2

      See identical proteins and their annotated locations for NP_766179.2

      Status: VALIDATED

      Source sequence(s)
      BB620239, BC052456, BE625696
      Consensus CDS
      CCDS56897.1
      UniProtKB/Swiss-Prot
      Q3UQN2
      Related
      ENSMUSP00000042959.8, ENSMUST00000040340.15
      Conserved Domains (2) summary
      cd07673
      Location:5273
      F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein
      cd09267
      Location:543809
      FCHo2_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      98723406..98815768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244652.2XP_011242954.1  F-BAR domain only protein 2 isoform X1

      Conserved Domains (2) summary
      cd07673
      Location:5248
      F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein
      cd09267
      Location:518784
      FCHo2_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins

    RNA

    1. XR_001780779.1 RNA Sequence

    2. XR_873743.2 RNA Sequence

    3. XR_001780778.1 RNA Sequence

      Related
      ENSMUST00000099277.11
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