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    Fcho2 FCH domain only 2 [ Mus musculus (house mouse) ]

    Gene ID: 218503, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fcho2provided by MGI
    Official Full Name
    FCH domain only 2provided by MGI
    Primary source
    MGI:MGI:3505790
    See related
    Ensembl:ENSMUSG00000041685 AllianceGenome:MGI:3505790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5832424M12Rik
    Summary
    Enables identical protein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and phosphatidylserine binding activity. Involved in membrane invagination; protein localization to plasma membrane; and synaptic vesicle endocytosis. Located in clathrin-coated vesicle and plasma membrane. Is active in clathrin-coated pit. Is expressed in endolymphatic appendage and head. Orthologous to human FCHO2 (FCH and mu domain containing endocytic adaptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 10.4), placenta adult (RPKM 8.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fcho2 in Genome Data Viewer
    Location:
    13 D1; 13 52.16 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (98859914..98953085, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (98723406..98816577, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 171 Neighboring gene predicted gene 9465 Neighboring gene predicted gene, 34995 Neighboring gene ribosomal protein S17 pseudogene Neighboring gene transportin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:99660904-99661128 Neighboring gene ribosomal protein L27A, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico. Katoh M, et al. Int J Mol Med, 2004 Aug. PMID 15254787
    2. Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature. Henne WM, et al. Structure, 2007 Jul. PMID 17540576
    3. Characterization of the EFC/F-BAR domain protein, FCHO2. Uezu A, et al. Genes Cells, 2011 Aug. PMID 21762413
    4. FCHo proteins are nucleators of clathrin-mediated endocytosis. Henne WM, et al. Science, 2010 Jun 4. PMID 20448150, Free PMC Article
    5. Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Umasankar PK, et al. Nat Cell Biol, 2012 Apr 8. PMID 22484487, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clathrin coat assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clathrin-dependent endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in membrane invagination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in clathrin-coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT colocalizes_with clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-BAR domain only protein 2
    Names
    FCH domain only protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172591.3 → NP_766179.2  F-BAR domain only protein 2

      See identical proteins and their annotated locations for NP_766179.2

      Status: VALIDATED

      Source sequence(s)
      BB620239, BC052456, BE625696
      Consensus CDS
      CCDS56897.1
      UniProtKB/Swiss-Prot
      Q3UJ91, Q3UQN2, Q7TMS9, Q8C0I2
      Related
      ENSMUSP00000042959.9, ENSMUST00000040340.16
      Conserved Domains (2) summary
      cd07673
      Location:5 → 273
      F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein
      cd09267
      Location:543 → 809
      FCHo2_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      98859914..98953085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244652.4 → XP_011242954.1  F-BAR domain only protein 2 isoform X1

      Conserved Domains (3) summary
      cd07673
      Location:5 → 248
      F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein
      cd09267
      Location:518 → 784
      FCHo2_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins
      pfam15685
      Location:423 → 476
      GGN; Gametogenetin

    RNA

    1. XR_873743.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UQN2.1 GenPept UniProtKB/Swiss-Prot:Q3UQN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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