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FCHO2 FCH and mu domain containing endocytic adaptor 2 [ Homo sapiens (human) ]

Gene ID: 115548, updated on 12-Oct-2019

Summary

Official Symbol
FCHO2provided by HGNC
Official Full Name
FCH and mu domain containing endocytic adaptor 2provided by HGNC
Primary source
HGNC:HGNC:25180
See related
Ensembl:ENSG00000157107 MIM:613438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in esophagus (RPKM 12.4), thyroid (RPKM 12.1) and 25 other tissues See more
Orthologs

Genomic context

See FCHO2 in Genome Data Viewer
Location:
5q13.2
Exon count:
28
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (72956041..73090522)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (72251808..72386349)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene transportin 1 Neighboring gene ribosomal protein L35a pseudogene 13 Neighboring gene microRNA 4804 Neighboring gene CTD nuclear envelope phosphatase 1 pseudogene Neighboring gene calcineurin like EF-hand protein 1 pseudogene Neighboring gene uncharacterized LOC105379030 Neighboring gene transmembrane protein 171

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
  • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytoskeletal protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin coat assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane invagination ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
presynaptic endocytic zone membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
F-BAR domain only protein 2
Names
FCH domain only 2
FCH domain only protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146032.2NP_001139504.1  F-BAR domain only protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The encoded isoform (b) is shorter compared to isoform a.
    Source sequence(s)
    AK295141, AL832928, BC137070
    Consensus CDS
    CCDS54868.1
    UniProtKB/Swiss-Prot
    Q0JRZ9
    Related
    ENSP00000427296.1, ENST00000512348.5
    Conserved Domains (2) summary
    cd09267
    Location:511777
    FCHo2_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins
    cl12013
    Location:5240
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_138782.3NP_620137.2  F-BAR domain only protein 2 isoform a

    See identical proteins and their annotated locations for NP_620137.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL832928, BC137070
    Consensus CDS
    CCDS47230.1
    UniProtKB/Swiss-Prot
    Q0JRZ9
    Related
    ENSP00000393776.2, ENST00000430046.7
    Conserved Domains (2) summary
    cd07673
    Location:5273
    F-BAR_FCHO2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH domain Only 2 protein
    cd09267
    Location:544810
    FCHo2_MHD; mu-homology domain (MHD) of F-BAR domain-containing Fer/Cip4 homology domain-only protein 2 (FCH domain only 2 or FCHo2) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    72956041..73090522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009016.2XP_016864505.1  F-BAR domain only protein 2 isoform X1

  2. XM_017009017.2XP_016864506.1  F-BAR domain only protein 2 isoform X2

  3. XM_017009020.2XP_016864509.1  F-BAR domain only protein 2 isoform X5

  4. XM_017009021.2XP_016864510.1  F-BAR domain only protein 2 isoform X5

  5. XM_017009018.2XP_016864507.1  F-BAR domain only protein 2 isoform X3

  6. XM_017009019.2XP_016864508.1  F-BAR domain only protein 2 isoform X4

  7. XM_017009022.2XP_016864511.1  F-BAR domain only protein 2 isoform X6

  8. XM_017009023.2XP_016864512.1  F-BAR domain only protein 2 isoform X7

RNA

  1. XR_001741993.2 RNA Sequence

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