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    Aurkb aurora kinase B [ Mus musculus (house mouse) ]

    Gene ID: 20877, updated on 14-Sep-2021

    Summary

    Official Symbol
    Aurkbprovided by MGI
    Official Full Name
    aurora kinase Bprovided by MGI
    Primary source
    MGI:MGI:107168
    See related
    Ensembl:ENSMUSG00000020897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I; AI; Stk; Aik2; Aim1; Ark2; AurB; IPL1; STK-; Stk1; Stk5; AIM-1; AIRK2; STK-1; Stk12; AL022959
    Summary
    This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 2 and 7. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in thymus adult (RPKM 36.3), liver E14.5 (RPKM 33.6) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Aurkb in Genome Data Viewer
    Location:
    11 B3; 11 42.32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68936450..68942490)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69045624..69051664)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68859145..68865164)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA glycine 6 (anticodon TCC) Neighboring gene nuclear encoded tRNA trytophan 7 (anticodon CCA) Neighboring gene BLOC-1 related complex subunit 6 Neighboring gene nuclear encoded tRNA isoleucine 4 (anticodon AAT)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone serine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone serine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3-S28 phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle midzone assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromocenter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of chromosome passenger complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromosome passenger complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    aurora kinase B
    Names
    ARK-2
    aurora 1
    aurora B
    aurora- and IPL1-like midbody-associated protein 1
    aurora-related kinase 2
    aurora/IPL1-related kinase 2
    serine/threonine kinase 12
    serine/threonine kinase 5
    serine/threonine-protein kinase 12
    serine/threonine-protein kinase 5
    serine/threonine-protein kinase aurora-B
    NP_035626.1
    XP_006532788.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011496.2NP_035626.1  aurora kinase B

      See identical proteins and their annotated locations for NP_035626.1

      Status: REVIEWED

      Source sequence(s)
      AK075951, BY005259, CO040997
      Consensus CDS
      CCDS24877.1
      UniProtKB/Swiss-Prot
      O70126
      Related
      ENSMUSP00000021277.6, ENSMUST00000021277.6
      Conserved Domains (2) summary
      smart00220
      Location:82332
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:77344
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      68936450..68942490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532725.4XP_006532788.1  aurora kinase B isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:13219
      PKc_like; Protein Kinases, catalytic domain
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