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    Aurkb aurora kinase B [ Mus musculus (house mouse) ]

    Gene ID: 20877, updated on 31-Jan-2019

    Summary

    Official Symbol
    Aurkbprovided by MGI
    Official Full Name
    aurora kinase Bprovided by MGI
    Primary source
    MGI:MGI:107168
    See related
    Ensembl:ENSMUSG00000020897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aik2; Aim1; Ark2; AurB; IPL1; Stk5; AIM-1; AIRK2; STK-1; Stk12; AL022959
    Summary
    This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 2 and 7. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in thymus adult (RPKM 36.3), liver E14.5 (RPKM 33.6) and 19 other tissues See more
    Orthologs

    Genomic context

    See Aurkb in Genome Data Viewer
    Location:
    11 B3; 11 42.32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (69045625..69051664)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68859145..68865164)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA glycine 6 (anticodon TCC) Neighboring gene nuclear encoded tRNA trytophan 7 (anticodon CCA) Neighboring gene BLOC-1 related complex subunit 6 Neighboring gene nuclear encoded tRNA isoleucine 4 (anticodon AAT)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone serine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone serine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    cleavage furrow formation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-S28 phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle assembly checkpoint IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle midzone assembly ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    chromocenter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromosome passenger complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome passenger complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    condensed nuclear chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    condensed nuclear chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed nuclear chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    spindle ISO
    Inferred from Sequence Orthology
    more info
     
    spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    aurora kinase B
    Names
    ARK-2
    aurora 1
    aurora B
    aurora- and IPL1-like midbody-associated protein 1
    aurora-related kinase 2
    aurora/IPL1-related kinase 2
    serine/threonine kinase 12
    serine/threonine kinase 5
    serine/threonine-protein kinase 12
    serine/threonine-protein kinase 5
    serine/threonine-protein kinase aurora-B
    NP_035626.1
    XP_006532788.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011496.2NP_035626.1  aurora kinase B

      See identical proteins and their annotated locations for NP_035626.1

      Status: REVIEWED

      Source sequence(s)
      AK075951, BY005259, CO040997
      Consensus CDS
      CCDS24877.1
      UniProtKB/Swiss-Prot
      O70126
      Related
      ENSMUSP00000021277.5, ENSMUST00000021277.5
      Conserved Domains (2) summary
      smart00220
      Location:82332
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:77344
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      69045625..69051664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532725.3XP_006532788.1  aurora kinase B isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:13207
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:13219
      PKc_like; Protein Kinases, catalytic domain
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