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    Mlxip MLX interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 208104, updated on 31-Jan-2019

    Summary

    Official Symbol
    Mlxipprovided by MGI
    Official Full Name
    MLX interacting proteinprovided by MGI
    Primary source
    MGI:MGI:2141183
    See related
    Ensembl:ENSMUSG00000038342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mir; bHLHe36; AW228700
    Expression
    Ubiquitous expression in spleen adult (RPKM 18.7), colon adult (RPKM 18.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mlxip in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (123394798..123457932)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (123844828..123907941)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35A, pseudogene 6 Neighboring gene WD repeat domain 66 Neighboring gene predicted gene 15860 Neighboring gene B cell CLL/lymphoma 7A Neighboring gene ribosomal protein L31, pseudogene 6 Neighboring gene interleukin 31

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Insulin resistance, organism-specific biosystem (from KEGG)
      Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0867, B930074I24

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    MLX-interacting protein
    Names
    Mlx interactor
    mlxip
    transcriptional activator MondoA

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133917.3NP_598678.2  MLX-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_598678.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AK047475, AY968204, BC067045
      Consensus CDS
      CCDS19662.1
      UniProtKB/Swiss-Prot
      Q2VPU4
      UniProtKB/TrEMBL
      G5E8D8
      Related
      ENSMUSP00000064943.5, ENSMUST00000068237.11
      Conserved Domains (3) summary
      cd00083
      Location:717771
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01698
      Location:425476
      FLO_LFY; Floricaula / Leafy protein
      cl21462
      Location:758799
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    2. NM_177582.3NP_808250.1  MLX-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_808250.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 1 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK047475, BB349293
      Consensus CDS
      CCDS39268.1
      UniProtKB/Swiss-Prot
      Q2VPU4
      UniProtKB/TrEMBL
      B2RQ56
      Related
      ENSMUSP00000107223.1, ENSMUST00000111596.7
      Conserved Domains (1) summary
      pfam01698
      Location:425476
      FLO_LFY; Floricaula / Leafy protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      123394798..123457932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530239.3XP_006530302.1  MLX-interacting protein isoform X1

      Conserved Domains (3) summary
      cd00083
      Location:717771
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01698
      Location:425476
      FLO_LFY; Floricaula / Leafy protein
      cl21462
      Location:758789
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
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