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MLXIP MLX interacting protein [ Homo sapiens (human) ]

Gene ID: 22877, updated on 1-Jun-2020

Summary

Official Symbol
MLXIPprovided by HGNC
Official Full Name
MLX interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:17055
See related
Ensembl:ENSG00000175727 MIM:608090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR; MONDOA; bHLHe36
Summary
This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in colon (RPKM 27.3), ovary (RPKM 19.2) and 25 other tissues See more
Orthologs

Genomic context

See MLXIP in Genome Data Viewer
Location:
12q24.31
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (122078744..122147344)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (122516652..122517172) , (122611800..122628989)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene BAF chromatin remodeling complex subunit BCL7A Neighboring gene uncharacterized LOC100506691 Neighboring gene Sharpr-MPRA regulatory region 8907 Neighboring gene leucine rich repeat containing 43 Neighboring gene interleukin 31 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 Neighboring gene diablo IAP-binding mitochondrial protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0867

Gene Ontology Provided by GOA

Component Evidence Code Pubs
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MLX-interacting protein
Names
Mlx interactor
class E basic helix-loop-helix protein 36
transcriptional activator MondoA

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033995.1 RefSeqGene

    Range
    5029..73617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014938.6NP_055753.3  MLX-interacting protein

    See identical proteins and their annotated locations for NP_055753.3

    Status: REVIEWED

    Source sequence(s)
    AF245480, AW996647, BC151841, BE207198, BM007462, BM558759, BM857835, BQ218664, BQ445885, CA426212
    Consensus CDS
    CCDS73540.1
    UniProtKB/Swiss-Prot
    Q9HAP2
    Related
    ENSP00000312834.6, ENST00000319080.12
    Conserved Domains (1) summary
    cd00083
    Location:718773
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    122078744..122147344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719290.4XP_006719353.1  MLX-interacting protein isoform X1

    Conserved Domains (1) summary
    cd00083
    Location:718774
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. XM_006719291.4XP_006719354.1  MLX-interacting protein isoform X2

    Conserved Domains (1) summary
    cd00083
    Location:718773
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  3. XM_006719292.4XP_006719355.1  MLX-interacting protein isoform X3

    Conserved Domains (1) summary
    cd00083
    Location:718774
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  4. XM_006719293.3XP_006719356.1  MLX-interacting protein isoform X4

    Conserved Domains (1) summary
    PHA03247
    Location:339568
    PHA03247; large tegument protein UL36; Provisional
  5. XM_006719294.4XP_006719357.1  MLX-interacting protein isoform X5

    Related
    ENSP00000440769.1, ENST00000538698.5
    Conserved Domains (2) summary
    cd00083
    Location:325381
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cl11531
    Location:368408
    DUF904; Protein of unknown function (DUF904)

RNA

  1. XR_944508.3 RNA Sequence

  2. XR_944509.3 RNA Sequence

  3. XR_001748624.2 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_011332697.1 Reference GRCh38.p13 PATCHES

    Range
    21022..86533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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