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    Pdpk1 3-phosphoinositide dependent protein kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18607, updated on 6-Sep-2021

    Summary

    Official Symbol
    Pdpk1provided by MGI
    Official Full Name
    3-phosphoinositide dependent protein kinase 1provided by MGI
    Primary source
    MGI:MGI:1338068
    See related
    Ensembl:ENSMUSG00000024122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pdk; Pdk1
    Annotation information
    Note: Pdk1 (Gene ID: 228026) and Pdpk1 (Gene ID: 18607) share the Pdk1 symbol/alias in common. Pdk1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (Pdpk1), which can be confused with the official symbol for pyruvate dehydrogenase kinase, isoenzyme 1 (Pdk1). [03 Apr 2019]
    Expression
    Ubiquitous expression in testis adult (RPKM 17.0), thymus adult (RPKM 9.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pdpk1 in Genome Data Viewer
    Location:
    17; 17 A3.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24292654..24370957, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24073680..24155619, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (24210647..24278561, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene protease, serine 27 Neighboring gene potassium channel tetramerisation domain containing 5 Neighboring gene predicted gene, 33409 Neighboring gene amidohydrolase domain containing 2 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3-phosphoinositide-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    3-phosphoinositide-dependent protein kinase 1
    Names
    Pkb kinase
    NP_001074242.1
    NP_001273591.1
    NP_035192.2
    XP_017172809.1
    XP_017172810.1
    XP_017172811.1
    XP_017172813.1
    XP_017172814.1
    XP_017172815.1
    XP_030105434.1
    XP_030105435.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080773.2NP_001074242.1  3-phosphoinositide-dependent protein kinase 1 isoform B

      See identical proteins and their annotated locations for NP_001074242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 3' region, compared to variant 1. The resulting isoform (B) is shorter and has a distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AK162677, BQ175596, BY257456
      Consensus CDS
      CCDS37483.1
      UniProtKB/TrEMBL
      Q3TRL2
      Related
      ENSMUSP00000111070.2, ENSMUST00000115411.8
      Conserved Domains (3) summary
      smart00220
      Location:85345
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:444521
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:83345
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    2. NM_001286662.1NP_001273591.1  3-phosphoinositide-dependent protein kinase 1 isoform C

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon, which results in translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (C) has a shorter N-terminus, compared to isoform A.
      Source sequence(s)
      AK147835, AK149162, CJ046953, CT010502
      Consensus CDS
      CCDS70767.1
      UniProtKB/TrEMBL
      F2Z3X6, Q3UGN6
      Related
      ENSMUSP00000061942.7, ENSMUST00000052462.13
      Conserved Domains (2) summary
      cd01262
      Location:417523
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:56318
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    3. NM_011062.4NP_035192.2  3-phosphoinositide-dependent protein kinase 1 isoform A

      See identical proteins and their annotated locations for NP_035192.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (A).
      Source sequence(s)
      AK147149, AK147835, BQ175596, BY257456, CT010502
      Consensus CDS
      CCDS28474.1
      UniProtKB/Swiss-Prot
      Q9Z2A0
      UniProtKB/TrEMBL
      Q3UGN6, Q3UHZ0
      Related
      ENSMUSP00000099991.4, ENSMUST00000102927.10
      Conserved Domains (3) summary
      smart00220
      Location:85345
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:444550
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:83345
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24292654..24370957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317324.3XP_017172813.1  3-phosphoinositide-dependent protein kinase 1 isoform X2

      Conserved Domains (2) summary
      cd01262
      Location:283389
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cl21453
      Location:47184
      PKc_like; Protein Kinases, catalytic domain
    2. XM_030249574.2XP_030105434.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

      Conserved Domains (2) summary
      cd01262
      Location:225331
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cl21453
      Location:1126
      PKc_like; Protein Kinases, catalytic domain
    3. XM_017317326.3XP_017172815.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      F2Z3X6
      Conserved Domains (2) summary
      cd01262
      Location:417523
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:56318
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    4. XM_017317325.3XP_017172814.1  3-phosphoinositide-dependent protein kinase 1 isoform X2

      Conserved Domains (2) summary
      cd01262
      Location:283389
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cl21453
      Location:47184
      PKc_like; Protein Kinases, catalytic domain
    5. XM_030249575.2XP_030105435.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

      Conserved Domains (2) summary
      cd01262
      Location:225331
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cl21453
      Location:1126
      PKc_like; Protein Kinases, catalytic domain
    6. XM_017317321.3XP_017172810.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      F2Z3X6
      Conserved Domains (2) summary
      cd01262
      Location:417523
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:56318
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    7. XM_017317320.3XP_017172809.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      F2Z3X6
      Conserved Domains (2) summary
      cd01262
      Location:417523
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:56318
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    8. XM_017317322.1XP_017172811.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      F2Z3X6
      Conserved Domains (2) summary
      cd01262
      Location:417523
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:56318
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
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