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PDPK1 3-phosphoinositide dependent protein kinase 1 [ Homo sapiens (human) ]

Gene ID: 5170, updated on 31-May-2022

Summary

Official Symbol
PDPK1provided by HGNC
Official Full Name
3-phosphoinositide dependent protein kinase 1provided by HGNC
Primary source
HGNC:HGNC:8816
See related
Ensembl:ENSG00000140992 MIM:605213; AllianceGenome:HGNC:8816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDK1; PDPK2; PDPK2P; PRO0461
Summary
Enables 3-phosphoinositide-dependent protein kinase activity; phospholipase activator activity; and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of protein kinase activity; and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection; cytosol; and plasma membrane. Implicated in prostate cancer. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: PDK1 (Gene ID: 5163) and PDPK1 (Gene ID: 5170) share the PDK1 symbol/alias in common. PDK1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (PDPK1). [01 Jun 2018]
Expression
Ubiquitous expression in brain (RPKM 5.6), testis (RPKM 5.3) and 25 other tissues See more
Orthologs
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Genomic context

See PDPK1 in Genome Data Viewer
Location:
16p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2538021..2603188)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2560174..2625339)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2588022..2653189)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene amidohydrolase domain containing 2 Neighboring gene microRNA 3178 Neighboring gene cementum protein 1 Neighboring gene potassium channel tetramerization domain containing 5 pseudogene Neighboring gene 3-phosphoinositide dependent protein kinase 2, pseudogene Neighboring gene uncharacterized LOC645644

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat A Coumarin derivative BPRHIV001 modulates HIV-1 Tat function through a reduction of the phosphorylated PDPK1 protein level PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20087, MGC35290

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of protein kinase B activity TAS
Traceable Author Statement
more info
 
involved_in calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hyperosmotic response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phospholipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 
involved_in type B pancreatic cell development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
3-phosphoinositide-dependent protein kinase 1
Names
3-phosphoinositide-dependent protein kinase 2 pseudogene
PkB kinase like gene 1
Putative 3-phosphoinositide-dependent protein kinase 2
NP_001248745.1
NP_002604.1
NP_112558.2
XP_011520823.1
XP_011520825.1
XP_024306064.1
XP_047290154.1
XP_047290155.1
XP_047290156.1
XP_047290157.1
XP_047290158.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261816.2NP_001248745.1  3-phosphoinositide-dependent protein kinase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB209835, AC141586
    Consensus CDS
    CCDS58411.1
    UniProtKB/Swiss-Prot
    O15530
    Related
    ENSP00000395357.3, ENST00000441549.7
    Conserved Domains (1) summary
    cd05581
    Location:80342
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  2. NM_002613.5NP_002604.1  3-phosphoinositide-dependent protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_002604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC141586, BC012103
    Consensus CDS
    CCDS10472.1
    UniProtKB/Swiss-Prot
    O15530
    Related
    ENSP00000344220.4, ENST00000342085.9
    Conserved Domains (2) summary
    cd01262
    Location:441547
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:80342
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  3. NM_031268.6NP_112558.2  3-phosphoinositide-dependent protein kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_112558.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC093525, AC141586, BC033494
    Consensus CDS
    CCDS10473.1
    UniProtKB/Swiss-Prot
    O15530
    Related
    ENSP00000268673.7, ENST00000268673.11
    Conserved Domains (2) summary
    cd01262
    Location:314420
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cl21453
    Location:81215
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2538021..2603188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434200.1XP_047290156.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

  2. XM_024450296.2XP_024306064.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

    Related
    ENSP00000373876.3, ENST00000389224.7
    Conserved Domains (2) summary
    cd01262
    Location:414520
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:53315
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  3. XM_047434199.1XP_047290155.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

  4. XM_047434202.1XP_047290158.1  3-phosphoinositide-dependent protein kinase 1 isoform X6

  5. XM_011522523.4XP_011520825.1  3-phosphoinositide-dependent protein kinase 1 isoform X4

    Conserved Domains (2) summary
    cd01262
    Location:348454
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cl21453
    Location:115249
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011522521.4XP_011520823.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:116376
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01262
    Location:475581
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:114376
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  7. XM_047434198.1XP_047290154.1  3-phosphoinositide-dependent protein kinase 1 isoform X2

  8. XM_047434201.1XP_047290157.1  3-phosphoinositide-dependent protein kinase 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2560174..2625339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)