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PDPK1 3-phosphoinositide dependent protein kinase 1 [ Homo sapiens (human) ]

Gene ID: 5170, updated on 22-Nov-2020

Summary

Official Symbol
PDPK1provided by HGNC
Official Full Name
3-phosphoinositide dependent protein kinase 1provided by HGNC
Primary source
HGNC:HGNC:8816
See related
Ensembl:ENSG00000140992 MIM:605213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDK1; PDPK2; PDPK2P; PRO0461
Annotation information
Note: PDK1 (Gene ID: 5163) and PDPK1 (Gene ID: 5170) share the PDK1 symbol/alias in common. PDK1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (PDPK1). [01 Jun 2018]
Expression
Ubiquitous expression in brain (RPKM 5.6), testis (RPKM 5.3) and 25 other tissues See more
Orthologs

Genomic context

See PDPK1 in Genome Data Viewer
Location:
16p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2538014..2603190)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2587965..2653191)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene amidohydrolase domain containing 2 Neighboring gene microRNA 3178 Neighboring gene cementum protein 1 Neighboring gene potassium channel tetramerization domain containing 5 pseudogene Neighboring gene 3-phosphoinositide dependent protein kinase 2, pseudogene Neighboring gene uncharacterized LOC645644

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat A Coumarin derivative BPRHIV001 modulates HIV-1 Tat function through a reduction of the phosphorylated PDPK1 protein level PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20087, MGC35290

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-phosphoinositide-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell costimulation TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase B activity TAS
Traceable Author Statement
more info
 
calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to brain-derived neurotrophic factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to epidermal growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phospholipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
3-phosphoinositide-dependent protein kinase 1
Names
3-phosphoinositide-dependent protein kinase 2 pseudogene
PkB kinase like gene 1
NP_001248745.1
NP_002604.1
NP_112558.2
XP_011520823.1
XP_011520825.1
XP_016878760.1
XP_016878761.1
XP_016878762.1
XP_016878763.1
XP_016878764.1
XP_016878765.1
XP_016878766.1
XP_024306063.1
XP_024306064.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261816.2NP_001248745.1  3-phosphoinositide-dependent protein kinase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB209835, AC141586
    Consensus CDS
    CCDS58411.1
    UniProtKB/Swiss-Prot
    O15530
    Related
    ENSP00000395357.3, ENST00000441549.7
    Conserved Domains (1) summary
    cd05581
    Location:80342
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  2. NM_002613.5NP_002604.1  3-phosphoinositide-dependent protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_002604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC141586, BC012103
    Consensus CDS
    CCDS10472.1
    UniProtKB/Swiss-Prot
    O15530
    Related
    ENSP00000344220.4, ENST00000342085.9
    Conserved Domains (3) summary
    smart00220
    Location:82342
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01262
    Location:441547
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:80342
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  3. NM_031268.6NP_112558.2  3-phosphoinositide-dependent protein kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_112558.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC093525, AC141586, BC033494
    Consensus CDS
    CCDS10473.1
    UniProtKB/Swiss-Prot
    O15530
    Related
    ENSP00000268673.7, ENST00000268673.11
    Conserved Domains (2) summary
    cd01262
    Location:314420
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cl21453
    Location:81215
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2538014..2603190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450296.1XP_024306064.1  3-phosphoinositide-dependent protein kinase 1 isoform X6

    Related
    ENSP00000373876.3, ENST00000389224.7
    Conserved Domains (2) summary
    cd01262
    Location:414520
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:53315
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  2. XM_017023274.1XP_016878763.1  3-phosphoinositide-dependent protein kinase 1 isoform X5

    Conserved Domains (2) summary
    cd01262
    Location:414491
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:53315
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  3. XM_017023273.2XP_016878762.1  3-phosphoinositide-dependent protein kinase 1 isoform X4

  4. XM_017023277.1XP_016878766.1  3-phosphoinositide-dependent protein kinase 1 isoform X10

  5. XM_017023276.1XP_016878765.1  3-phosphoinositide-dependent protein kinase 1 isoform X9

  6. XM_024450295.1XP_024306063.1  3-phosphoinositide-dependent protein kinase 1 isoform X5

    Conserved Domains (2) summary
    cd01262
    Location:414491
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:53315
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  7. XM_017023275.2XP_016878764.1  3-phosphoinositide-dependent protein kinase 1 isoform X7

  8. XM_017023271.2XP_016878760.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

  9. XM_011522523.3XP_011520825.1  3-phosphoinositide-dependent protein kinase 1 isoform X8

    Conserved Domains (2) summary
    cd01262
    Location:348454
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cl21453
    Location:115249
    PKc_like; Protein Kinases, catalytic domain
  10. XM_011522521.3XP_011520823.1  3-phosphoinositide-dependent protein kinase 1 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:116376
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01262
    Location:475581
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:114376
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
  11. XM_017023272.2XP_016878761.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

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