AGER advanced glycosylation end-product specific receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: AGERprovided by HGNC
Official Full Name: advanced glycosylation end-product specific receptorprovided by HGNC
Primary source: HGNC:HGNC:320
See related: Ensembl:ENSG00000204305 MIM:600214; AllianceGenome:HGNC:320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAGE; sRAGE; SCARJ1
Summary: The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
Expression: Biased expression in lung (RPKM 397.6) and spleen (RPKM 11.0) See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.32

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (32180969..32184253, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (32034160..32037444, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (32148746..32152030, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Association of HMGB1 and RAGE Gene Polymorphisms with IgA Vasculitis.
Title: The Association of HMGB1 and RAGE Gene Polymorphisms with IgA Vasculitis.
Association Between the G82S Polymorphism of the Receptor Gene for Advanced Glycation End-products and Soluble Serum Levels RAGE with Diabetic Nephropathy in the White (Asian) Race.
Title: Association Between the G82S Polymorphism of the Receptor Gene for Advanced Glycation End-products and Soluble Serum Levels RAGE with Diabetic Nephropathy in the White (Asian) Race.
Targeting TNF-alpha-induced expression of TTR and RAGE in rheumatoid arthritis: Apigenin's mediated therapeutic approach.
Title: Targeting TNF-α-induced expression of TTR and RAGE in rheumatoid arthritis: Apigenin's mediated therapeutic approach.
Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV).
Title: Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV).
The critical role of RAGE in severe influenza infection: A target for control of inflammatory response in the disease.
Title: The critical role of RAGE in severe influenza infection: A target for control of inflammatory response in the disease.
S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kB/VEGF-D pathway.
Title: S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kB/VEGF-D pathway.
The RAGE/DIAPH1 axis: mediator of obesity and proposed biomarker of human cardiometabolic disease.
Title: The RAGE/DIAPH1 axis: mediator of obesity and proposed biomarker of human cardiometabolic disease.
Nepsilon-(1-Carboxymethyl)-L-lysine/RAGE Signaling Drives Metastasis and Cancer Stemness through ERK/NFkappaB axis in Osteosarcoma.
Title: Nε-(1-Carboxymethyl)-L-lysine/RAGE Signaling Drives Metastasis and Cancer Stemness through ERK/NFκB axis in Osteosarcoma.
RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation.
Title: RAGE in circulating immune cells is fundamental for hippocampal inflammation and cognitive decline in a mouse model of latent chronic inflammation.
RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity.
Title: RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity.

Submit: New GeneRIF Correction See all GeneRIFs (934)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies five loci associated with lung function. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat downregulates OCLN (occludin) and LRP1 and upregulates AGER (RAGE), and in a RhoA/ROCK1 dependent manner as shown through hydroxyfasudil inhibition in hCMEC/D3 cells	PubMed
capsid	gag	RAGE inhibits the release of HIV-1 in terms of reduced levels of CA in virus particles and induces the accumulation of cell-associated CA	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC203021P1 (e-PCR)
- UniSTS:271895

GDB:607721 (e-PCR)
- UniSTS:158271

RH67947 (e-PCR)
- UniSTS:87104

RH40485 (e-PCR)
- UniSTS:85336

PMC162222P2 (e-PCR)
- UniSTS:271464

D6S1871 (e-PCR)
- UniSTS:54378

STS-D60277 (e-PCR)
- UniSTS:54384

MARC_10431-10432:999637141:1 (e-PCR)
- UniSTS:267139

RH46823 (e-PCR)
- UniSTS:88721

D3S4540 (e-PCR)
- UniSTS:53681

RH65115 (e-PCR)
- UniSTS:85939

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables S100 protein binding	IEA Inferred from Electronic Annotation more info
enables S100 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables advanced glycation end-product receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
enables amyloid-beta binding	IPI Inferred from Physical Interaction more info	PubMed
enables amyloid-beta binding	NAS Non-traceable Author Statement more info	PubMed
enables amyloid-beta binding	TAS Traceable Author Statement more info	PubMed
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables scavenger receptor activity	TAS Traceable Author Statement more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in astrocyte activation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within astrocyte development	IEA Inferred from Electronic Annotation more info
involved_in astrocyte development	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in glucose mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within induction of positive chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in learning or memory	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microglial cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microglial cell activation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood circulation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood circulation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within negative regulation of connective tissue replacement involved in inflammatory response wound healing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of long-term synaptic depression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of long-term synaptic potentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of amyloid precursor protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of double-strand break repair	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelin production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelin production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of heterotypic cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of monocyte chemotactic protein-1 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of p38MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within protein localization to membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of CD4-positive, alpha-beta T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of non-canonical NF-kappaB signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of spontaneous synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic plasticity	TAS Traceable Author Statement more info	PubMed
involved_in response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in response to amyloid-beta	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to amyloid-beta	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	TAS Traceable Author Statement more info	PubMed
involved_in transcytosis	IEA Inferred from Electronic Annotation more info
involved_in transcytosis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in transport across blood-brain barrier	IDA Inferred from Direct Assay more info	PubMed
involved_in transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	NAS Non-traceable Author Statement more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in postsynapse	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: advanced glycosylation end product-specific receptor

Names: receptor for advanced glycation end-products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029868.2 RefSeqGene

Range

5000..8284

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001136.5 → NP_001127.1 advanced glycosylation end product-specific receptor isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as RAGE) represents the predominant transcript, and encodes isoform 1.

Source sequence(s)

AL662884

Consensus CDS

CCDS4746.1

UniProtKB/Swiss-Prot

A2BFI7, A6NKF0, A7Y2U9, B0V176, Q15109, Q15279, Q3L1R4, Q3L1R5, Q3L1R6, Q3L1R7, Q3L1R8, Q3L1S0, Q86SN1, Q9H2X7, Q9Y3R3, V5R6A3

UniProtKB/TrEMBL

A0A1U9X782, A0A1U9X785, A0A1U9X790

Related

ENSP00000364217.4, ENST00000375076.9

Conserved Domains (3) summary

smart00410
Location:24 → 117

IG_like; Immunoglobulin like

pfam08205
Location:124 → 219

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:241 → 304

Ig_3; Immunoglobulin domain
NM_001206929.2 → NP_001193858.1 advanced glycosylation end product-specific receptor isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as RAGE_v5) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a longer isoform (2) containing an additional protein segment compared to isoform 1.

Source sequence(s)

AL662884

Consensus CDS

CCDS75429.1

UniProtKB/TrEMBL

A0A0G2JL65

Related

ENSP00000364210.4, ENST00000375069.7

Conserved Domains (3) summary

smart00410
Location:24 → 117

IG_like; Immunoglobulin like

pfam08205
Location:124 → 235

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:257 → 320

Ig_3; Immunoglobulin domain
NM_001206932.2 → NP_001193861.1 advanced glycosylation end product-specific receptor isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as RAGE_v4) uses alternate in-frame acceptor and donor splice sites at two internal coding exons compared to variant 1. This results in a shorter isoform (2) missing two internal protein segments compared to isoform 1.

Source sequence(s)

AL662884

UniProtKB/TrEMBL

A0A1U9X782, A0A1U9X790

Related

ENSP00000521524.1, ENST00000851465.1

Conserved Domains (3) summary

smart00410
Location:24 → 103

IG_like; Immunoglobulin like

pfam08205
Location:110 → 205

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:227 → 290

Ig_3; Immunoglobulin domain
NM_001206934.2 → NP_001193863.1 advanced glycosylation end product-specific receptor isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as RAGE_v6) lacks the penultimate coding exon, and uses alternate donor splice sites at two internal coding exons compared to variant 1. This results in a frame-shift and a shorter isoform (4) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AL662884

Consensus CDS

CCDS56417.1

UniProtKB/TrEMBL

A0A0G2JL37

Related

ENSP00000387887.2, ENST00000438221.6

Conserved Domains (3) summary

smart00410
Location:24 → 117

IG_like; Immunoglobulin like

pfam08205
Location:124 → 235

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:257 → 320

Ig_3; Immunoglobulin domain
NM_001206936.2 → NP_001193865.1 advanced glycosylation end product-specific receptor isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as RAGE_v9) lacks the penultimate coding exon, and uses alternate acceptor and donor splice sites at two internal coding exons compared to variant 1. This results in a frame-shift and a shorter isoform (5) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AL662884

UniProtKB/TrEMBL

Q101R5

Conserved Domains (2) summary

smart00410
Location:24 → 117

IG_like; Immunoglobulin like

pfam08205
Location:124 → 219

C2-set_2; CD80-like C2-set immunoglobulin domain
NM_001206940.2 → NP_001193869.1 advanced glycosylation end product-specific receptor isoform 6 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6, also known as RAGE_v1) lacks the penultimate coding exon, and uses an alternate donor splice site at another coding exon compared to variant 1. This results in a frame-shift and a shorter isoform (6, also known as esRAGE and soluble RAGE) with a distinct C-terminus compared to isoform 1. This isoform lacks the transmembrane and intracellular domains, is secreted (PMID:18089847), and thought to function as a decoy receptor that inhibits RAGE signaling, and thus prevent the pathological progression of some pathologic conditions, such as Alzheimer's disease (PMID:18431028). Variants 6 and 9 encode the same isoform.

Source sequence(s)

AL662884

Consensus CDS

CCDS56418.1

UniProtKB/TrEMBL

A0A0G2JJF5

Related

ENSP00000364195.2, ENST00000375055.6

Conserved Domains (3) summary

smart00410
Location:24 → 117

IG_like; Immunoglobulin like

pfam08205
Location:124 → 219

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:241 → 304

Ig_3; Immunoglobulin domain
NM_001206954.2 → NP_001193883.1 advanced glycosylation end product-specific receptor isoform 8 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8, also known as RAGE_v8) lacks two internal coding exons, and uses an alternate donor splice site at another coding exon compared to variant 1. This results in a frame-shift, and a shorter isoform (8) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AL662884

UniProtKB/TrEMBL

Q101R5

Conserved Domains (2) summary

smart00410
Location:24 → 117

IG_like; Immunoglobulin like

pfam08205
Location:124 → 219

C2-set_2; CD80-like C2-set immunoglobulin domain
NM_001206966.2 → NP_001193895.1 advanced glycosylation end product-specific receptor isoform 6 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (9, also known as RAGE_v10) lacks the penultimate coding exon, and uses alternate splice sites at other exons at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (6, also known as esRAGE and soluble RAGE) with a distinct C-terminus compared to isoform 1. Variants 6 and 9 encode the same isoform.

Source sequence(s)

AL662884

Consensus CDS

CCDS56418.1

UniProtKB/TrEMBL

A0A0G2JJF5

Conserved Domains (3) summary

smart00410
Location:24 → 117

IG_like; Immunoglobulin like

pfam08205
Location:124 → 219

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:241 → 304

Ig_3; Immunoglobulin domain
NM_172197.3 → NP_751947.1 advanced glycosylation end product-specific receptor isoform 7 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7, also known as RAGE_v16) uses alternate splice sites at several internal coding exons compared to variant 1. This results in a frame-shift and a shorter isoform (7, also known as hRAGEsec) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AL662884

Consensus CDS

CCDS4747.1

UniProtKB/TrEMBL

A0A0G2JID9

Related

ENSP00000364208.3, ENST00000375067.7

Conserved Domains (2) summary

smart00410
Location:24 → 103

IG_like; Immunoglobulin like

pfam08205
Location:110 → 205

C2-set_2; CD80-like C2-set immunoglobulin domain

RNA

NR_038190.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (10, also known as RAGE_v2) is alternatively spliced at the 5' end compared to variant 1. It is represented as non-coding because the use of the 5'-most translation start codon (with a strong Kozak signal), renders this transcript a candidate for nonsense-mediated mRNA decay (NMD). Transfection studies also could not detect expression of any protein from this variant (PMID:18089847).

Source sequence(s)

AL662884

Related

ENST00000484849.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

32180969..32184253 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017010328.3 → XP_016865817.2 advanced glycosylation end product-specific receptor isoform X1

UniProtKB/TrEMBL

Q101R5
XM_047418261.1 → XP_047274217.1 advanced glycosylation end product-specific receptor isoform X3

UniProtKB/TrEMBL

Q101R3, Q101R5
XM_047418260.1 → XP_047274216.1 advanced glycosylation end product-specific receptor isoform X2

UniProtKB/TrEMBL

Q101R5

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

3513571..3516855 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328451.1 → XP_054184426.1 advanced glycosylation end product-specific receptor isoform X1

UniProtKB/TrEMBL

Q101R5
XM_054328453.1 → XP_054184428.1 advanced glycosylation end product-specific receptor isoform X3

UniProtKB/TrEMBL

Q101R5
XM_054328452.1 → XP_054184427.1 advanced glycosylation end product-specific receptor isoform X2

UniProtKB/TrEMBL

Q101R5

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

Range

3619321..3622605 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329741.1 → XP_054185716.1 advanced glycosylation end product-specific receptor isoform X1

UniProtKB/TrEMBL

Q101R5
XM_054329743.1 → XP_054185718.1 advanced glycosylation end product-specific receptor isoform X3

UniProtKB/TrEMBL

Q101R3, Q101R5
XM_054329742.1 → XP_054185717.1 advanced glycosylation end product-specific receptor isoform X2

UniProtKB/TrEMBL

Q101R5

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

Range

3485950..3489234 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330529.1 → XP_054186504.1 advanced glycosylation end product-specific receptor isoform X1

UniProtKB/TrEMBL

Q101R5
XM_054330531.1 → XP_054186506.1 advanced glycosylation end product-specific receptor isoform X3

UniProtKB/TrEMBL

Q101R3, Q101R5
XM_054330530.1 → XP_054186505.1 advanced glycosylation end product-specific receptor isoform X2

UniProtKB/TrEMBL

Q101R5

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

Range

3522988..3526272 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330776.1 → XP_054186751.1 advanced glycosylation end product-specific receptor isoform X1

UniProtKB/TrEMBL

Q101R5
XM_054330778.1 → XP_054186753.1 advanced glycosylation end product-specific receptor isoform X3

UniProtKB/TrEMBL

Q101R5
XM_054330777.1 → XP_054186752.1 advanced glycosylation end product-specific receptor isoform X2

UniProtKB/TrEMBL

Q101R5

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

Range

3404170..3407454 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331012.1 → XP_054186987.1 advanced glycosylation end product-specific receptor isoform X1

UniProtKB/TrEMBL

Q101R5
XM_054331014.1 → XP_054186989.1 advanced glycosylation end product-specific receptor isoform X3

UniProtKB/TrEMBL

Q101R3, Q101R5
XM_054331013.1 → XP_054186988.1 advanced glycosylation end product-specific receptor isoform X2

UniProtKB/TrEMBL

Q101R5

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

Range

3497176..3500460 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331278.1 → XP_054187253.1 advanced glycosylation end product-specific receptor isoform X1

UniProtKB/TrEMBL

Q101R5
XM_054331280.1 → XP_054187255.1 advanced glycosylation end product-specific receptor isoform X3

UniProtKB/TrEMBL

Q101R3, Q101R5
XM_054331279.1 → XP_054187254.1 advanced glycosylation end product-specific receptor isoform X2

UniProtKB/TrEMBL

Q101R5

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

32034160..32037444 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054354413.1 → XP_054210388.1 advanced glycosylation end product-specific receptor isoform X1

UniProtKB/TrEMBL

Q101R5
XM_054354415.1 → XP_054210390.1 advanced glycosylation end product-specific receptor isoform X3

UniProtKB/TrEMBL

Q101R3, Q101R5
XM_054354414.1 → XP_054210389.1 advanced glycosylation end product-specific receptor isoform X2

UniProtKB/TrEMBL

Q101R5