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Ager advanced glycosylation end product-specific receptor [ Mus musculus (house mouse) ]

Gene ID: 11596, updated on 10-Jan-2023

Summary

Official Symbol
Agerprovided by MGI
Official Full Name
advanced glycosylation end product-specific receptorprovided by MGI
Primary source
MGI:MGI:893592
See related
Ensembl:ENSMUSG00000015452 AllianceGenome:MGI:893592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RAGE
Summary
Enables S100 protein binding activity; advanced glycation end-product binding activity; and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of long-term synaptic potentiation; and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of advanced glycation end-product receptor activity; and positive regulation of macromolecule metabolic process. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward lung adult (RPKM 481.7) See more
Orthologs
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Try the new Transcript table

Genomic context

See Ager in Genome Data Viewer
Location:
17; 17 B1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34816545..34819911)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34597460..34600937)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene G-protein signalling modulator 3 (AGS3-like, C. elegans) Neighboring gene pre B cell leukemia homeobox 2 Neighboring gene ring finger protein 5 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) Neighboring gene EGF-like domain 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables high mobility group box 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables laminin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within astrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within induction of positive chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood circulation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelin production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of monocyte chemotactic protein-1 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of monocyte extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of CD4-positive, alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of T cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of p38MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of p38MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of spontaneous synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transcytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
advanced glycosylation end product-specific receptor
Names
advanced glycation end-products receptor
receptor for advanced glycosylation end products

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271422.1NP_001258351.1  advanced glycosylation end product-specific receptor isoform b precursor

    See identical proteins and their annotated locations for NP_001258351.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK004802, CT009767
    Consensus CDS
    CCDS70795.1
    UniProtKB/Swiss-Prot
    Q62151
    Related
    ENSMUSP00000134401.2, ENSMUST00000174496.9
    Conserved Domains (3) summary
    smart00408
    Location:249304
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:24116
    IG; Immunoglobulin
    pfam08205
    Location:123216
    C2-set_2; CD80-like C2-set immunoglobulin domain
  2. NM_001271423.1NP_001258352.1  advanced glycosylation end product-specific receptor isoform c precursor

    See identical proteins and their annotated locations for NP_001258352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an in-frame exon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    CT009767
    Consensus CDS
    CCDS70796.1
    UniProtKB/Swiss-Prot
    Q62151
    Related
    ENSMUSP00000134579.2, ENSMUST00000173992.8
    Conserved Domains (3) summary
    smart00408
    Location:240295
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:24107
    IG_like; Immunoglobulin like
    pfam08205
    Location:114207
    C2-set_2; CD80-like C2-set immunoglobulin domain
  3. NM_001271424.1NP_001258353.1  advanced glycosylation end product-specific receptor isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple differences in the coding region, compared to variant 1, and initiates translation at an alternate start codon. The encodes isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    CT009767
    Related
    ENSMUST00000184805.8
    Conserved Domains (3) summary
    smart00410
    Location:159235
    IG_like; Immunoglobulin like
    pfam08205
    Location:40133
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cd00096
    Location:5660
    Ig; Ig strand B [structural motif]
  4. NM_007425.3NP_031451.2  advanced glycosylation end product-specific receptor isoform a precursor

    See identical proteins and their annotated locations for NP_031451.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC061182, CT009767
    Consensus CDS
    CCDS28649.1
    UniProtKB/Swiss-Prot
    Q62151, V5R4Y0
    Related
    ENSMUSP00000015596.4, ENSMUST00000015596.10
    Conserved Domains (4) summary
    smart00408
    Location:249304
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:242318
    IG_like; Immunoglobulin like
    pfam08205
    Location:123216
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:24110
    Ig; Immunoglobulin domain

RNA

  1. NR_073173.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate splicing structure near the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CT009767
    Related
    ENSMUST00000174069.8
  2. NR_073175.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has an alternate splicing structure near the 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CT009767
    Related
    ENSMUST00000173589.8
  3. NR_073176.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has an alternate splicing structure near the 5' end, and lacks an exon near the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CT009767
    Related
    ENSMUST00000172932.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34816545..34819911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523501.4XP_006523564.1  advanced glycosylation end product-specific receptor isoform X1

    See identical proteins and their annotated locations for XP_006523564.1

    Conserved Domains (3) summary
    smart00408
    Location:249277
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:24116
    IG; Immunoglobulin
    pfam08205
    Location:123216
    C2-set_2; CD80-like C2-set immunoglobulin domain