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    CTBS chitobiase [ Homo sapiens (human) ]

    Gene ID: 1486, updated on 5-Mar-2024

    Summary

    Official Symbol
    CTBSprovided by HGNC
    Official Full Name
    chitobiaseprovided by HGNC
    Primary source
    HGNC:HGNC:2496
    See related
    Ensembl:ENSG00000117151 MIM:600873; AllianceGenome:HGNC:2496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CTB
    Summary
    Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins (Aronson and Kuranda, 1989 [PubMed 2531691]).[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in prostate (RPKM 12.0), liver (RPKM 10.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See CTBS in Genome Data Viewer
    Location:
    1p22.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (84549611..84574440, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (84389989..84414814, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (85015294..85040123, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5400 Neighboring gene deoxyribonuclease 2 beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1250 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:84944610-84945170 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1252 Neighboring gene ribosome production factor 1 homolog Neighboring gene NANOG hESC enhancer GRCh37_chr1:84969365-84969870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1020 Neighboring gene G protein subunit gamma 5 Neighboring gene spermatogenesis associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1021 Neighboring gene uncharacterized LOC105378819 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:85044029-85044228 Neighboring gene long intergenic non-protein coding RNA 1461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1023

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: GNG5

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    di-N-acetylchitobiase
    Names
    chitobiase, di-N-acetyl-
    NP_004379.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004388.3NP_004379.1  di-N-acetylchitobiase precursor

      See identical proteins and their annotated locations for NP_004379.1

      Status: VALIDATED

      Source sequence(s)
      AI339601, AL359762, BC065191, BC126335
      Consensus CDS
      CCDS698.1
      UniProtKB/Swiss-Prot
      Q01459, Q5VX50
      UniProtKB/TrEMBL
      B2RBF5
      Related
      ENSP00000359664.4, ENST00000370630.6
      Conserved Domains (2) summary
      cd02875
      Location:39378
      GH18_chitobiase; Chitobiase (also known as di-N-acetylchitobiase) is a lysosomal glycosidase that hydrolyzes the reducing-end N-acetylglucosamine from the chitobiose core of oligosaccharides during the ordered degradation of asparagine-linked glycoproteins in eukaryotes. ...
      smart00636
      Location:115358
      Glyco_18; Glyco_18 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      84549611..84574440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      84389989..84414814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)