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GNG5 G protein subunit gamma 5 [ Homo sapiens (human) ]

Gene ID: 2787, updated on 23-Nov-2021

Summary

Official Symbol
GNG5provided by HGNC
Official Full Name
G protein subunit gamma 5provided by HGNC
Primary source
HGNC:HGNC:4408
See related
Ensembl:ENSG00000174021 MIM:600874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in colon (RPKM 64.2), bone marrow (RPKM 52.7) and 25 other tissues See more
Orthologs
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Genomic context

See GNG5 in Genome Data Viewer
Location:
1p22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (84498325..84506581, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (84964008..84972264, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene urate oxidase (pseudogene) Neighboring gene deoxyribonuclease 2 beta Neighboring gene ribosome production factor 1 homolog Neighboring gene spermatogenesis associated 1 Neighboring gene chitobiase Neighboring gene uncharacterized LOC105378819

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Potential readthrough

Included gene: CTBS

Homology

Clone Names

  • FLJ92393

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables PDZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Names
guanine nucleotide binding protein (G protein), gamma 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005274.3NP_005265.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

    See identical proteins and their annotated locations for NP_005265.1

    Status: VALIDATED

    Source sequence(s)
    AL359762, BC003563, BM809260, BM834854
    Consensus CDS
    CCDS696.1
    UniProtKB/Swiss-Prot
    P63218
    Related
    ENSP00000359679.4, ENST00000370645.9
    Conserved Domains (1) summary
    cd00068
    Location:763
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    84498325..84506581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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