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GNG5 G protein subunit gamma 5 [ Homo sapiens (human) ]

Gene ID: 2787, updated on 7-Apr-2024

Summary

Official Symbol
GNG5provided by HGNC
Official Full Name
G protein subunit gamma 5provided by HGNC
Primary source
HGNC:HGNC:4408
See related
Ensembl:ENSG00000174021 MIM:600874; AllianceGenome:HGNC:4408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in colon (RPKM 64.2), bone marrow (RPKM 52.7) and 25 other tissues See more
Orthologs
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Genomic context

See GNG5 in Genome Data Viewer
Location:
1p22.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (84498325..84506581, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (84338707..84346962, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (84964008..84972264, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:84830842-84832041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1249 Neighboring gene urate oxidase (pseudogene) Neighboring gene Sharpr-MPRA regulatory region 5400 Neighboring gene deoxyribonuclease 2 beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1250 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:84944610-84945170 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1252 Neighboring gene NANOG hESC enhancer GRCh37_chr1:84969365-84969870 Neighboring gene ribosome production factor 1 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1020 Neighboring gene spermatogenesis associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1253 Neighboring gene chitobiase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1021 Neighboring gene uncharacterized LOC105378819 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:85044029-85044228

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Names
guanine nucleotide binding protein (G protein), gamma 5
NP_005265.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005274.3NP_005265.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

    See identical proteins and their annotated locations for NP_005265.1

    Status: VALIDATED

    Source sequence(s)
    AL359762, BC003563, BM809260, BM834854
    Consensus CDS
    CCDS696.1
    UniProtKB/Swiss-Prot
    B2R5A0, P30670, P63218, Q5VX54, Q61015
    Related
    ENSP00000359679.4, ENST00000370645.9
    Conserved Domains (1) summary
    cd00068
    Location:763
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    84498325..84506581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    84338707..84346962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)