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CTBS chitobiase [ Homo sapiens (human) ]

Gene ID: 1486, updated on 12-Oct-2019

Summary

Official Symbol
CTBSprovided by HGNC
Official Full Name
chitobiaseprovided by HGNC
Primary source
HGNC:HGNC:2496
See related
Ensembl:ENSG00000117151 MIM:600873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTB
Summary
Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins (Aronson and Kuranda, 1989 [PubMed 2531691]).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in prostate (RPKM 12.0), liver (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See CTBS in Genome Data Viewer
Location:
1p22.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (84549611..84574440, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (85018804..85048039, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene deoxyribonuclease 2 beta Neighboring gene ribosome production factor 1 homolog Neighboring gene G protein subunit gamma 5 Neighboring gene spermatogenesis associated 1 Neighboring gene uncharacterized LOC105378819 Neighboring gene long intergenic non-protein coding RNA 1461

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: GNG5

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chitin binding IEA
Inferred from Electronic Annotation
more info
 
chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space HDA PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
di-N-acetylchitobiase
Names
chitobiase, di-N-acetyl-
NP_004379.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004388.3NP_004379.1  di-N-acetylchitobiase precursor

    See identical proteins and their annotated locations for NP_004379.1

    Status: VALIDATED

    Source sequence(s)
    AI339601, AL359762, BC065191, BC126335
    Consensus CDS
    CCDS698.1
    UniProtKB/Swiss-Prot
    Q01459
    UniProtKB/TrEMBL
    Q8TC97
    Related
    ENSP00000359664.4, ENST00000370630.6
    Conserved Domains (2) summary
    cd02875
    Location:39378
    GH18_chitobiase; Chitobiase (also known as di-N-acetylchitobiase) is a lysosomal glycosidase that hydrolyzes the reducing-end N-acetylglucosamine from the chitobiose core of oligosaccharides during the ordered degradation of asparagine-linked glycoproteins in eukaryotes. ...
    smart00636
    Location:115358
    Glyco_18; Glyco_18 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    84549611..84574440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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