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    ZNF98 zinc finger protein 98 [ Homo sapiens (human) ]

    Gene ID: 148198, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF98provided by HGNC
    Official Full Name
    zinc finger protein 98provided by HGNC
    Primary source
    HGNC:HGNC:13174
    See related
    Ensembl:ENSG00000197360 MIM:603980; AllianceGenome:HGNC:13174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    F7175; ZNF739
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 2.3), kidney (RPKM 0.7) and 13 other tissues See more
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    Genomic context

    See ZNF98 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (22391019..22422346, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (22529651..22560967, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (22573821..22605148, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372330 Neighboring gene ribosomal protein L34 pseudogene 34 Neighboring gene uncharacterized LOC105376917 Neighboring gene BCL2 interacting protein 3 pseudogene 32 Neighboring gene BCL2 interacting protein 3 pseudogene 33

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
    EBI GWAS Catalog
    Genome-wide association scan of dental caries in the permanent dentition.
    EBI GWAS Catalog
    GWAS of dental caries patterns in the permanent dentition.
    EBI GWAS Catalog

    General gene information

    Markers

    Clone Names

    • MGC129634

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 98
    Names
    zinc finger protein 739
    zinc finger protein F7175

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098626.2NP_001092096.1  zinc finger protein 98

      See identical proteins and their annotated locations for NP_001092096.1

      Status: VALIDATED

      Source sequence(s)
      AC011494, AC011516
      Consensus CDS
      CCDS46031.1
      UniProtKB/Swiss-Prot
      A6NK75
      Related
      ENSP00000350418.4, ENST00000357774.9
      Conserved Domains (6) summary
      smart00349
      Location:1373
      KRAB; krueppel associated box
      COG5048
      Location:179563
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:324344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:350372
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1352
      KRAB; KRAB box
      pfam13465
      Location:364389
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      22391019..22422346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      22529651..22560967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)