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    Gna13 guanine nucleotide binding protein, alpha 13 [ Mus musculus (house mouse) ]

    Gene ID: 14674, updated on 22-Aug-2021

    Summary

    Official Symbol
    Gna13provided by MGI
    Official Full Name
    guanine nucleotide binding protein, alpha 13provided by MGI
    Primary source
    MGI:MGI:95768
    See related
    Ensembl:ENSMUSG00000020611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Galp; AU024132; AU043124; Galpha13
    Expression
    Ubiquitous expression in colon adult (RPKM 6.4), thymus adult (RPKM 6.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gna13 in Genome Data Viewer
    Location:
    11 E1; 11 71.88 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109253620..109292195)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109362794..109401369)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (109224108..109262683)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1600015H23 gene Neighboring gene RIKEN cDNA 1700096J18 gene Neighboring gene predicted gene 11696 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene predicted gene, 45916 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D5 dopamine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables D5 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of phospholipase D activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in activation of phospholipase D activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in multicellular organism aging IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in multicellular organism aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of heterotrimeric G-protein complex ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    part_of heterotrimeric G-protein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein subunit alpha-13
    Names
    G-protein subunit alpha-13
    g alpha-13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359034.1NP_001345963.1  guanine nucleotide-binding protein subunit alpha-13 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 3' terminal exon, resulting in novel 3' UTR and 3' coding region. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK011851, BE943634, BY711071, BY742974
      Consensus CDS
      CCDS88277.1
      Related
      ENSMUSP00000102313.4, ENSMUST00000106702.4
      Conserved Domains (1) summary
      smart00275
      Location:29172
      G_alpha; G protein alpha subunit
    2. NM_010303.3NP_034433.3  guanine nucleotide-binding protein subunit alpha-13 isoform 1

      See identical proteins and their annotated locations for NP_034433.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant 1 represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK011851, AK149766, AL645791, BC032937, CJ180381
      Consensus CDS
      CCDS25577.1
      UniProtKB/Swiss-Prot
      P27601
      UniProtKB/TrEMBL
      Q3UE40, Q8K086, Q9D034
      Related
      ENSMUSP00000020930.8, ENSMUST00000020930.14
      Conserved Domains (2) summary
      cd00066
      Location:49371
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:29375
      G_alpha; G protein alpha subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      109253620..109292195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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