Conserved Protein Domain Family
G_alpha

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smart00275: G_alpha 
G protein alpha subunit
Subunit of G proteins that contains the guanine nucleotide binding site
Statistics
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PSSM-Id: 214595
View PSSM: smart00275
Aligned: 48 rows
Threshold Bit Score: 301.034
Threshold Setting Gi: 71022605
Created: 13-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

smart00275 is classified as a model that may span more than one domain.
smart00275 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1AZS_C      20 REANKKIEKQLQKDKQVYr----------ATHRLLLLGAGESGKSTIVKQMRILHVNGFNGDgEKATKVQDIKNNLKEAI 89
gi 1169856  51 KAVNKQIEKQLKEEKKIMd----------sELKLLLLGTGDSGKSTVVKQMKILHLEGYSQE-ERINQRQFVYRNIIEIA 119
gi 3877737  21 VEHNKSIENDLEKDRKIK------------ILKLLILGPGESGKSTTIKQIKIIHDEGYSAE-EKMVRKHGIYMNILEGI 87
gi 120986   13 AKQNKIINTELDKAKKTDe----------NIIKLLLLGAGESGKSTVLKQMKIIHNSGFSQE-EISNKRNVVCANTVQAM 81
gi 1498498  57 LQKHKSIEKQLQLDGKNKnk--------iPVLKLLLLGTGESGKSTVVKQMKILHHKGFSKE-EEEFYRNLIYINLLDGM 127
gi 1280080  17 IKVNKEIEKQLEKKKNMQl-----------EQTVLLLGPGESGKSTVMKQMRAMTGN-YTKT-ELHERKVLIIQNLCQFS 83
gi 1346103  19 NTQTAEIERRIELETKAEk----------HIQKLLLLGAGESGKSTIFKQIKLLFQTGFDEA-ELKSYQPVIHANVYQTI 87
gi 949880    9 VARSRSIDHQLDEERERRe----------KEVQILIIGGPGAGKSTFIKQLRLHYGDQFPPN-ERRLFHDQILQNVAMGL 77
gi 1072255  13 ELQNRQIDTQIRIENQANk----------RKIKMLLLGVTDSGKSTIVKQMRVNYLDGFNET-EVVNAIFVIRNNIIDAF 81
gi 3924699   5 FSSQSKLQVPEIRASRSItpasqksedpysHIRLLLLGSAESGKTTVLEQVRLLYKQHFTES-EYFHRRAFIYHNIFKSI 83
                       90       100       110       120       130       140       150       160
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1AZS_C      90 ETIVAAMSNLVPPVELANpe--------nqFRVDYILS------VMNVPDfd---------------------------- 127
gi 1169856 120 YSIIRGCGVLNLTIPSQFd------------sICSSIEei---yETKNYTnl---------------------------- 156
gi 3877737  88 EEIHLSVGRENKSYKNPLsfd-------hinEVRMFTEnf---kKADDSEkl---------------------------- 129
gi 120986   82 GALLDGMKQLQFDFSTRVc----------nAHEKLIREt-----LNDKAEygp--------------------------- 119
gi 1498498 128 ALLIHVIKENNIEIPQETlsai----knysSWYRVYIE------KRNKNGirnnpigsmipisilnnnkdnnnsnssslk 197
gi 1280080  84 EMLLEYVREYILEMTEDDd-----------KRYTVMCEe----lKMAVIHdgi--------------------------- 121
gi 1346103  88 KLLHDGAKELAQNDVDF---------------SKYVISdenkeiGEKLSEiggrld------------------------ 128
gi 949880   78 VHLIEHMERMGLQFETPEvqdlsrefrkkhPRISIVTLikkfkeENEKAEeicpvttraelt------------------ 139
gi 1072255  82 KNICNIILHSDITVTQEEk------------VLVKLFAy-------ESGKiel--------------------------- 115
gi 3924699  84 KALCRAMRMSDIQFADPIn----------mGRAQSIIA-------DEHGHygl--------------------------- 119
                      170       180       190       200       210       220       230       240
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1AZS_C     128 -------------------------------------------------------------------fpPEFYEHAKALW 140
gi 1169856 157 --------------------------------------------------------------------dKNVLKGVAELS 168
gi 3877737 130 -------------------------------------------------------------------lgPEVINAIQKYI 142
gi 120986  120 -------------------------------------------------------------------fsDAMFNALTELW 132
gi 1498498 198 nnsggsssseldkkmthlsldgstcinsnsaspngpssstttstinthnrsnsdgssnnifnvqdfgipPIITNYISTIW 277
gi 1280080 122 -------------------------------------------------------------------mrPELADTLKEFW 134
gi 1346103 129 ----------------------------------------------------------------ypcltKELALEIENLW 144
gi 949880  140 ---------------------------------------------------------krlssfdvynpeVPNVDDMHTLW 162
gi 1072255 116 ------------------------------------------------------------------mqeVDELNVINAVS 129
gi 3924699 120 -------------------------------------------------------------------fsKDLAEKIKHIW 132
                      250       260       270       280       290       300       310       320
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1AZS_C     141 EDEGVRACYE-RSNEY---QLIDC-------------------------AQYFLDKIDVIKQDDYVPSDQDLLRCRVLTS 191
gi 1169856 169 KNESFINAANnSGSNF---QLHSSsq-------------------------yFLDDIARFSEEDYIPTDQDILYTRVAST 220
gi 3877737 143 KDETIAMMLR-DKTVY---NIDDSti-------------------------yFLENFSRIIQKDYLPTEEDILKSRVPTS 193
gi 120986  133 ADKGVQCAYD-KREFF---YLHDS-------------------------AKYFLDRIARVHTPNYVPTENDILHTRVPTM 183
gi 1498498 278 SDPVVQSEVMlQAQKY---HINES-------------------------TQYYLNEIKRIGKPTYQPVNLDILKSRATTN 329
gi 1280080 135 GNSAIQDAYS-KRDTF---HLTDSakkmfqliqkhvskmsemflkiffyVTHFFDNIDRIKLPGFEPTNQDIVHIRVPTT 210
gi 1346103 145 KDAAIQETYA-RGNEL---QVPDC-------------------------THYFMENLHRLSDANYVPTKDDVLYARVRTT 195
gi 949880  163 ADPAMQICFE-KRNKFetdKLTHS-------------------------SEYFLLHIGRICSKEYLASVQDILLIRWPTL 216
gi 1072255 130 GYECIKQFFE-RFAFHp--MVPDH-------------------------IHYFYPNLDRIASSNYVPTAEDLIHMRQTTL 181
gi 3924699 133 NDKSMQKLYA-RRSQF---NLNDS-------------------------ASYFLNNIDKINMVDYKPSERDLIMAYVPTC 183
                      330       340       350       360       370       380       390       400
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1AZS_C     192 GIFETKFQVDKVNF------HMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQT---------------- 249
gi 1169856 221 SVSETRFSVRGIKf------RMIDVAGQRGHRDKWIHHFSEVTAILFVISLCEYDQVLEEDGKT---------------- 278
gi 3877737 194 GVIQYKIMLKNFNf------RIFDVGGQRAQRRKWLHVFDDVQAVLFITSLSEYDQVLREDATV---------------- 251
gi 120986  184 GVIEVNFTIKGKFF------RVFDVGGQRSQRKKWIHCFDDAKAMIYVASLSEYDQVLLEDNTT---------------- 241
gi 1498498 330 GVVETDFNVNGEVIf-----RIVDVAGQRGERKKWINFFDDVTAIVFVAAINEYDQKLVEDNCT---------------- 388
gi 1280080 211 GVAQVEVIMNNIKL------MICDCGGQRSERRKWYHFFDEADAVLFVAAISEFDQKLAEDEET---------------- 268
gi 1346103 196 GVVEIQFSPVGENKksgevyRLFDVGGQRNERRKWIHLFEGVSAVIFCAAISEYDQTLFEDENK---------------- 259
gi 949880  217 GVQEHKFMVDGLLY------RMIDVAGQRSLRKKWIHFFDEVAAVAFFVNLTAYDEFTEEDPTV---------------- 274
gi 1072255 182 GVHEISFDYTKHII------RLIDVGGQKTERRKWIHFFEGVTAVMFVCSLASFNQTTEEEPKAfvwesslnkvqnkvlv 255
gi 3924699 184 GVQNVIFTACNQSF------QLFDIGGQKIDRRKWALQYEGIDAIFFCIAISEYDQVMSEDMVT---------------- 241
                      410       420       430       440       450       460       470       480
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1AZS_C     250 --------------NRLQEALNLFKSIWNNRWLRT-ISVILFLNKQDLLAEKVLAGksKIEDYFPEFARyttpedatpep 314
gi 1169856 279 --------------NRMIESIKVFGDIINQRLFKD-IPIILFLNKRDLFAEKIKKT--GISICFPDYTGp---------- 331
gi 3877737 252 --------------NRMKESLNLFEKICNGRYFLN-TAMILFLNKIDLFKIKIKHT--NITVALTSYKGp---------- 304
gi 120986  242 --------------NRMHESIQLFKQVINNKYFVN-TSVILFLNKIDLFEEKIVTKkrSLGIAFESFSGp---------- 296
gi 1498498 389 --------------NRLHESLNLFDSICNDSTFPK-TSIILFLNKIDLFREKLKRT--SINICFPDYNGd---------- 441
gi 1280080 269 --------------NRMHESIRLFWTVFNGKFFKK-AAVILFLNKIDLFEEKVKHV--KIKDYFPKFEGa---------- 321
gi 1346103 260 --------------NRMMETKELFEWVLKQPCFEK-TSFMLFLNKFDIFEKKILKVplNVCEWFKDYQPvst-------- 316
gi 949880  275 --------------NSLQDSLQAFAEISHSQFLDK-TDFILFLNKKDLFANKLKTS--SIATCFPDYKGp---------- 327
gi 1072255 256 rsagkakvekpgliNRLDESVDLFKSIREN-SFLKmSNFMLFLNKKDLLTKKLTKV--VFSDYFPDYKKwit-------- 324
gi 3924699 242 --------------NRLDDALNLLQSISEDPAFAT-TPIYLFLNEIDVFCEKLSVI--PLSKYKPDFKGg---------- 294
                      490       500       510       520       530       540
               ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1AZS_C     315 gedPRVTRAKYFIRDEFLRISTas---gdGRHYCYPHFTC-AVDTENIRRVFNDCRDIIQRMHLRQYE 378
gi 1169856 332 --sDDYEQSLVFLKKKILSANKt-------sKAVYTNVTT-ATDTTNIGHVFEAVKDILTRQTMEEGG 389
gi 3877737 305 ---QECDSALDYIRKRFISLNKn------KKRSIYEHVTC-ATDTEQIQVVIDSVIDVVIQHTMQKVG 362
gi 120986  297 --sQDLNAAVAFVEKKYRSMAEn------KEKNIYCHHTC-ATDTQQVQYVLDAVLDTILSTKLKGCG 355
gi 1498498 442 ---QSYEKSSNYIKNNFLSKKKggn-ginSQNFIYFHFTC-ATDTKSFETVFNSVRDIIISKTLEFYC 504
gi 1280080 322 ---NTVSEGTKFFRRQFREGIHp-----dFKKRMYTHETC-AIS-DQVQIIINTVIDTVIQDNLKDTG 379
gi 1346103 317 -gkqEIEHAYEFVKKKFEESYFqntapdrVDRVFKIYRTT-ALDQKVVKKTFKLVDETLRRRNLFEAG 382
gi 949880  328 ---NTVDASLKYIKEQFLQSKP-------AQKQVYSHATC-AIDVPHMKDLLATVVDCIVDINVKRSK 384
gi 1072255 325 -ndNSDVSVAEFIENMFREGLE-------PEKRMYAHLTQ-ATVTANIEGTFALCCDVIFGKNYEDTN 383
gi 3924699 295 ----DQDDAIDFMENLACEALGk------rDRSLYRVYRCiAIDTQMMAELLSTCFLKKERRLIRYAN 352
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