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GNA13 G protein subunit alpha 13 [ Homo sapiens (human) ]

Gene ID: 10672, updated on 1-Jun-2020

Summary

Official Symbol
GNA13provided by HGNC
Official Full Name
G protein subunit alpha 13provided by HGNC
Primary source
HGNC:HGNC:4381
See related
Ensembl:ENSG00000120063 MIM:604406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G13
Expression
Ubiquitous expression in bone marrow (RPKM 46.2), lymph node (RPKM 22.6) and 24 other tissues See more
Orthologs

Genomic context

See GNA13 in Genome Data Viewer
Location:
17q24.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (65009289..65056740, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (63005407..63052920, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985000 Neighboring gene SLC16A6 pseudogene 1 Neighboring gene archaelysin family metallopeptidase 2 pseudogene 1 Neighboring gene uncharacterized LOC105371864 Neighboring gene uncharacterized LOC100507002

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variants and gene expression associated with white matter microstructure in the human brain.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC46138

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D5 dopamine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of phospholipase D activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
brush border membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit alpha-13
Names
g alpha-13
guanine nucleotide binding protein (G protein), alpha 13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282425.1NP_001269354.1  guanine nucleotide-binding protein subunit alpha-13 isoform 2

    See identical proteins and their annotated locations for NP_001269354.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC037487, AK302400, AW298099
    Consensus CDS
    CCDS62302.1
    UniProtKB/Swiss-Prot
    Q14344
    Related
    ENSP00000439647.1, ENST00000541118.1
    Conserved Domains (1) summary
    cd00066
    Location:1276
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  2. NM_006572.6NP_006563.2  guanine nucleotide-binding protein subunit alpha-13 isoform 1

    See identical proteins and their annotated locations for NP_006563.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC037487, AF493902, AW298099, DC335364
    Consensus CDS
    CCDS11661.1
    UniProtKB/Swiss-Prot
    Q14344
    UniProtKB/TrEMBL
    A0A024R8M0
    Related
    ENSP00000400717.2, ENST00000439174.7
    Conserved Domains (1) summary
    smart00275
    Location:29375
    G_alpha; G protein alpha subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    65009289..65056740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524202.1XP_011522504.1  guanine nucleotide-binding protein subunit alpha-13 isoform X1

    See identical proteins and their annotated locations for XP_011522504.1

    Conserved Domains (1) summary
    cl21455
    Location:49187
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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