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    Eif4a1 eukaryotic translation initiation factor 4A1 [ Mus musculus (house mouse) ]

    Gene ID: 13681, updated on 22-Aug-2021

    Summary

    Official Symbol
    Eif4a1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4A1provided by MGI
    Primary source
    MGI:MGI:95303
    See related
    Ensembl:ENSMUSG00000059796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif; Eif4; Ddx2a; BM-010
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 322.5), placenta adult (RPKM 214.5) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Eif4a1 in Genome Data Viewer
    Location:
    11 B3; 11 42.86 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69557762..69563249, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69666936..69672423, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69480438..69485925, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 1934 Neighboring gene CD68 antigen Neighboring gene predicted gene, 24029 Neighboring gene predicted gene, 25835 Neighboring gene predicted gene, 22988 Neighboring gene SUMO/sentrin specific peptidase 3 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13, opposite strand Neighboring gene tumor necrosis factor (ligand) superfamily, membrane-bound member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic initiation factor 4A-I
    Names
    ATP-dependent RNA helicase eIF4A-1
    eIF-4A-I
    eIF4A-I
    initiation factor eIF-4A long form
    NP_001152847.1
    NP_659207.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159375.1NP_001152847.1  eukaryotic initiation factor 4A-I isoform 2

      See identical proteins and their annotated locations for NP_001152847.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL603707, AW493973
      UniProtKB/TrEMBL
      Q3TLL6
      Conserved Domains (3) summary
      smart00487
      Location:47249
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:246359
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:34235
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    2. NM_144958.4NP_659207.1  eukaryotic initiation factor 4A-I isoform 1

      See identical proteins and their annotated locations for NP_659207.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK169030, AL603707, AW493973
      Consensus CDS
      CCDS24904.1
      UniProtKB/Swiss-Prot
      P60843
      UniProtKB/TrEMBL
      Q5F2A7
      Related
      ENSMUSP00000127034.3, ENSMUST00000163666.3
      Conserved Domains (1) summary
      PTZ00424
      Location:20406
      PTZ00424; helicase 45; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69557762..69563249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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