U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ccnf cyclin F [ Mus musculus (house mouse) ]

    Gene ID: 12449, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ccnfprovided by MGI
    Official Full Name
    cyclin Fprovided by MGI
    Primary source
    MGI:MGI:102551
    See related
    Ensembl:ENSMUSG00000072082 AllianceGenome:MGI:102551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CycF; Fbxo1
    Summary
    Predicted to enable anaphase-promoting complex binding activity and cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within negative regulation of centrosome duplication; placenta development; and re-entry into mitotic cell cycle. Predicted to be located in cell junction; centriole; and centrosome. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in liver lobe; midbrain ventricular layer; and telencephalon. Orthologous to human CCNF (cyclin F). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 29.9), thymus adult (RPKM 27.8) and 18 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ccnf in Genome Data Viewer
    Location:
    17 A3.3; 17 12.32 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24441518..24470333, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24223230..24251409, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-positive B cell enhancer ABC_E2472 Neighboring gene netrin 3 Neighboring gene tubulin epsilon and delta complex 2 Neighboring gene STARR-seq mESC enhancer starr_42081 Neighboring gene microRNA 5134 Neighboring gene STARR-seq mESC enhancer starr_42082 Neighboring gene microRNA 6965 Neighboring gene ATP-binding cassette, sub-family A member 17 Neighboring gene STARR-seq mESC enhancer starr_42083 Neighboring gene STARR-positive B cell enhancer ABC_E9436 Neighboring gene ATP-binding cassette, sub-family A member 3 Neighboring gene predicted gene, 25618

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism. Noonan ML, et al. JCI Insight, 2024 Jun 25. PMID 38916959, Free PMC Article
    2. Mouse cyclin F maps to a conserved linkage group on mouse chromosome 17. Obermayr F, et al. Mamm Genome, 1995 Feb. PMID 7767003
    3. Cyclin F disruption compromises placental development and affects normal cell cycle execution. Tetzlaff MT, et al. Mol Cell Biol, 2004 Mar. PMID 14993286, Free PMC Article
    4. Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. Kong M, et al. EMBO J, 2000 Mar 15. PMID 10716937, Free PMC Article
    5. Identification of genes regulated by an interaction between alphavbeta3 integrin and vitronectin in murine decidua. Mangale SS, et al. Reprod Fertil Dev, 2008. PMID 18255021

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism.
      Title: Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism.
    2. Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity
      Title: Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity.
    3. SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity
      Title: SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.
    4. CycF(-/-) animals, with a myriad of developmental anomalies due in large part to failures in yolk sac and chorioallantoic placentation, die around embryonic day 10.5.
      Title: Cyclin F disruption compromises placental development and affects normal cell cycle execution.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables anaphase-promoting complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of centrosome duplication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within re-entry into mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cyclin-F
    Names
    G2/mitotic-specific cyclin-F

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409800.1 → NP_001396729.1  cyclin-F isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117577

    2. NM_001409801.1 → NP_001396730.1  cyclin-F isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117577

    3. NM_001409803.1 → NP_001396732.1  cyclin-F isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117577

    4. NM_001409804.1 → NP_001396733.1  cyclin-F isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC117577

    5. NM_001409805.1 → NP_001396734.1  cyclin-F isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC117577

    6. NM_001409806.1 → NP_001396735.1  cyclin-F isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC117577

    7. NM_001409807.1 → NP_001396736.1  cyclin-F isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC117577

    8. NM_001409808.1 → NP_001396737.1  cyclin-F isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC117577

    9. NM_001409809.1 → NP_001396738.1  cyclin-F isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117577

    10. NM_001409832.1 → NP_001396761.1  cyclin-F isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC117577

    11. NM_007634.5 → NP_031660.3  cyclin-F isoform 4

      See identical proteins and their annotated locations for NP_031660.3

      Status: VALIDATED

      Source sequence(s)
      AC117577
      Consensus CDS
      CCDS37484.1
      UniProtKB/Swiss-Prot
      P51944, Q3TF73, Q60797, Q60799, Q8BSX9, Q8C4D9, Q8CI26
      Related
      ENSMUSP00000111048.4, ENSMUST00000115390.5
      Conserved Domains (3) summary
      smart00256
      Location:35 → 73
      FBOX; A Receptor for Ubiquitination Targets
      pfam00134
      Location:281 → 406
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:425 → 531
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24441518..24470333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51944.2 GenPept UniProtKB/Swiss-Prot:P51944

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous