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    Ccnf cyclin F [ Mus musculus (house mouse) ]

    Gene ID: 12449, updated on 3-Feb-2019

    Summary

    Official Symbol
    Ccnfprovided by MGI
    Official Full Name
    cyclin Fprovided by MGI
    Primary source
    MGI:MGI:102551
    See related
    Ensembl:ENSMUSG00000072082
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CycF; Fbxo1
    Expression
    Broad expression in liver E14.5 (RPKM 29.9), thymus adult (RPKM 27.8) and 18 other tissues See more
    Orthologs

    Genomic context

    See Ccnf in Genome Data Viewer
    Location:
    17 A3.3; 17 12.32 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (24223230..24251409, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (24360177..24388354, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 24 Neighboring gene netrin 3 Neighboring gene tubulin epsilon and delta complex 2 Neighboring gene microRNA 5134 Neighboring gene microRNA 6965 Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 17 Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 3 Neighboring gene RIKEN cDNA D330041H03 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    re-entry into mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    centriole ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-F
    Names
    G2/mitotic-specific cyclin-F

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007634.4NP_031660.3  cyclin-F

      See identical proteins and their annotated locations for NP_031660.3

      Status: PROVISIONAL

      Source sequence(s)
      AK159594
      Consensus CDS
      CCDS37484.1
      UniProtKB/Swiss-Prot
      P51944
      Related
      ENSMUSP00000111048.3, ENSMUST00000115390.4
      Conserved Domains (3) summary
      smart00256
      Location:3573
      FBOX; A Receptor for Ubiquitination Targets
      pfam00134
      Location:281406
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:425531
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      24223230..24251409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523554.1XP_006523617.1  cyclin-F isoform X1

      Conserved Domains (3) summary
      smart00256
      Location:4886
      FBOX; A Receptor for Ubiquitination Targets
      pfam00134
      Location:294419
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:438544
      Cyclin_C; Cyclin, C-terminal domain
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