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CCNF cyclin F [ Homo sapiens (human) ]

Gene ID: 899, updated on 7-Jul-2019

Summary

Official Symbol
CCNFprovided by HGNC
Official Full Name
cyclin Fprovided by HGNC
Primary source
HGNC:HGNC:1591
See related
Ensembl:ENSG00000162063 MIM:600227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX1; FBXO1
Summary
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 3.5), bone marrow (RPKM 2.7) and 24 other tissues See more
Orthologs

Genomic context

See CCNF in Genome Data Viewer
Location:
16p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2429447..2458854)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2479395..2508859)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 17, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3130 Neighboring gene conserved acetylation island sequence C01 enhancer Neighboring gene microRNA 6767 Neighboring gene uncharacterized LOC105371050 Neighboring gene uncharacterized LOC729652 Neighboring gene tubulin epsilon and delta complex 2 Neighboring gene microRNA 6768

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of centrosome duplication IDA
Inferred from Direct Assay
more info
PubMed 
placenta development IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
re-entry into mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclin-F
Names
F-box only protein 1
G2/mitotic-specific cyclin-F

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323538.2NP_001310467.1  cyclin-F isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB208829, AC106820, BQ009827, HY027359
    UniProtKB/TrEMBL
    Q59HD0
  2. NM_001761.3NP_001752.2  cyclin-F isoform 1

    See identical proteins and their annotated locations for NP_001752.2

    Status: REVIEWED

    Source sequence(s)
    AB208829, BC012349, DB523776, Z36714
    Consensus CDS
    CCDS10467.1
    UniProtKB/Swiss-Prot
    P41002
    UniProtKB/TrEMBL
    Q59HD0
    Related
    ENSP00000380256.4, ENST00000397066.9
    Conserved Domains (5) summary
    smart00256
    Location:3573
    FBOX; A Receptor for Ubiquitination Targets
    COG0790
    Location:88146
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:88112
    SLR; SLR repeat [structural motif]
    pfam00134
    Location:281406
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:421531
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2429447..2458854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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