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    CAP1 cyclase associated actin cytoskeleton regulatory protein 1 [ Homo sapiens (human) ]

    Gene ID: 10487, updated on 9-Jun-2024

    Summary

    Official Symbol
    CAP1provided by HGNC
    Official Full Name
    cyclase associated actin cytoskeleton regulatory protein 1provided by HGNC
    Primary source
    HGNC:HGNC:20040
    See related
    Ensembl:ENSG00000131236 MIM:617801; AllianceGenome:HGNC:20040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAP; CAP1-PEN
    Summary
    The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]
    Expression
    Ubiquitous expression in appendix (RPKM 105.5), lymph node (RPKM 89.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CAP1 in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40040240..40072648)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (39909560..39942077)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40505912..40538320)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:40363871-40364442 Neighboring gene MYCL antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 716 Neighboring gene MYCL proto-oncogene, bHLH transcription factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40409912-40410434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 823 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40446045-40446898 Neighboring gene ribosomal protein S2 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 718 Neighboring gene uncharacterized LOC105378669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 824 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40505419-40506052 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40506053-40506687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40518723-40519222 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:40524580-40525341 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:40535511-40536710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 720 Neighboring gene Sharpr-MPRA regulatory region 13734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 829 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40598557-40599056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 830 Neighboring gene uncharacterized LOC105378671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 831 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 721 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:40625521-40625722 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40626731-40627347 Neighboring gene OAZ1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenylate cyclase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ameboidal-type cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment or maintenance of cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in focal adhesion HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adenylyl cyclase-associated protein 1
    Names
    CAP, adenylate cyclase-associated protein 1
    adenylate cyclase associated protein 1
    testis secretory sperm-binding protein Li 218p

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105530.2NP_001099000.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000361883.3, ENST00000372797.7
      Conserved Domains (2) summary
      pfam01213
      Location:562
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319473
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    2. NM_001330502.2NP_001317431.2  adenylyl cyclase-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS81304.1
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000344832.3, ENST00000340450.7
      Conserved Domains (2) summary
      pfam01213
      Location:561
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    3. NM_001350475.2NP_001337404.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:562
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319473
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    4. NM_001350476.2NP_001337405.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:562
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319473
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    5. NM_001350477.3NP_001337406.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000361878.2, ENST00000372792.7
      Conserved Domains (2) summary
      pfam01213
      Location:562
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319473
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    6. NM_001350478.2NP_001337407.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:562
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319473
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    7. NM_001350479.2NP_001337408.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:562
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319473
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    8. NM_001350480.2NP_001337409.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:562
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319473
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    9. NM_001350481.2NP_001337410.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:562
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319473
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    10. NM_001350482.2NP_001337411.2  adenylyl cyclase-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS81304.1
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000361884.1, ENST00000372798.5
      Conserved Domains (2) summary
      pfam01213
      Location:561
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    11. NM_001350483.2NP_001337412.2  adenylyl cyclase-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS81304.1
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000361888.1, ENST00000372802.5
      Conserved Domains (2) summary
      pfam01213
      Location:561
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    12. NM_001350484.2NP_001337413.2  adenylyl cyclase-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS81304.1
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:561
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    13. NM_001350485.2NP_001337414.2  adenylyl cyclase-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 3 and 11-14 encode the same isoform (b).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS81304.1
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:561
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    14. NM_006367.4NP_006358.2  adenylyl cyclase-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 4-10 encode the same isoform (a).
      Source sequence(s)
      AL512599
      Consensus CDS
      CCDS41309.1
      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Related
      ENSP00000361891.3, ENST00000372805.8
      Conserved Domains (2) summary
      pfam01213
      Location:562
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319473
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      40040240..40072648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431628.1XP_047287584.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9
    2. XM_047431636.1XP_047287592.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9
    3. XM_047431520.1XP_047287476.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9
    4. XM_047431420.1XP_047287376.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
    5. XM_011540515.2XP_011538817.1  adenylyl cyclase-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011538817.1

      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:561
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:318472
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    6. XM_011540510.2XP_011538812.1  adenylyl cyclase-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011538812.1

      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:562
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319473
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    7. XM_047431603.1XP_047287559.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9
    8. XM_017000069.2XP_016855558.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
      Conserved Domains (2) summary
      pfam01213
      Location:562
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:319473
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    9. XM_047431580.1XP_047287536.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9
    10. XM_047431489.1XP_047287445.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q01518, Q53HR7, Q5T0S1, Q5T0S2, Q6I9U6
      UniProtKB/TrEMBL
      B2RDY9
    11. XM_047431616.1XP_047287572.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      39909560..39942077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333863.1XP_054189838.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9
    2. XM_054333864.1XP_054189839.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9
    3. XM_054333858.1XP_054189833.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9
    4. XM_054333854.1XP_054189829.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      B2RDY9, D3DPU2
    5. XM_054333859.1XP_054189834.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9
    6. XM_054333856.1XP_054189831.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      B2RDY9, D3DPU2
    7. XM_054333861.1XP_054189836.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9
    8. XM_054333855.1XP_054189830.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      B2RDY9, D3DPU2
    9. XM_054333860.1XP_054189835.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9
    10. XM_054333857.1XP_054189832.1  adenylyl cyclase-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      B2RDY9, D3DPU2
    11. XM_054333862.1XP_054189837.1  adenylyl cyclase-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RDY9