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Cap1 cyclase associated actin cytoskeleton regulatory protein 1 [ Mus musculus (house mouse) ]

Gene ID: 12331, updated on 12-May-2024

Summary

Official Symbol
Cap1provided by MGI
Official Full Name
cyclase associated actin cytoskeleton regulatory protein 1provided by MGI
Primary source
MGI:MGI:88262
See related
Ensembl:ENSMUSG00000028656 AllianceGenome:MGI:88262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in large intestine adult (RPKM 69.4), thymus adult (RPKM 59.2) and 28 other tissues See more
Orthologs
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Genomic context

See Cap1 in Genome Data Viewer
Location:
4 D2.2; 4 57.27 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (122752841..122779869, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (122859048..122886076, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30548 Neighboring gene STARR-seq mESC enhancer starr_11275 Neighboring gene predicted gene 12873 Neighboring gene STARR-seq mESC enhancer starr_11276 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122504971-122505172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122525696-122525897 Neighboring gene STARR-positive B cell enhancer ABC_E2709 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122549318-122549471 Neighboring gene STARR-seq mESC enhancer starr_11277 Neighboring gene STARR-seq mESC enhancer starr_11278 Neighboring gene STARR-positive B cell enhancer ABC_E3510 Neighboring gene STARR-positive B cell enhancer mm9_chr4:122616319-122616620 Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenylate cyclase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
adenylyl cyclase-associated protein 1
Names
CAP, adenylate cyclase-associated protein 1
adenylyl cyclase-associated CAP protein, yeast homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301067.3NP_001287996.1  adenylyl cyclase-associated protein 1

    See identical proteins and their annotated locations for NP_001287996.1

    Status: REVIEWED

    Source sequence(s)
    AL606906, BX545849
    Consensus CDS
    CCDS18604.1
    UniProtKB/Swiss-Prot
    P40124, Q8BPT7
    UniProtKB/TrEMBL
    Q3UVJ2
    Related
    ENSMUSP00000068260.6, ENSMUST00000069533.12
    Conserved Domains (2) summary
    pfam01213
    Location:561
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318472
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  2. NM_001358035.2NP_001344964.1  adenylyl cyclase-associated protein 1

    Status: REVIEWED

    Source sequence(s)
    AL606906, BX545849
    Consensus CDS
    CCDS18604.1
    UniProtKB/Swiss-Prot
    P40124, Q8BPT7
    UniProtKB/TrEMBL
    Q3UVJ2
    Related
    ENSMUSP00000101864.4, ENSMUST00000106257.10
    Conserved Domains (2) summary
    pfam01213
    Location:561
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318472
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  3. NM_001358036.2NP_001344965.1  adenylyl cyclase-associated protein 1

    Status: REVIEWED

    Source sequence(s)
    AL606906, BX545849
    Consensus CDS
    CCDS18604.1
    UniProtKB/Swiss-Prot
    P40124, Q8BPT7
    UniProtKB/TrEMBL
    Q3UVJ2
    Conserved Domains (2) summary
    pfam01213
    Location:561
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318472
    CAP_C; Adenylate cyclase associated (CAP) C terminal
  4. NM_001430094.1NP_001417023.1  adenylyl cyclase-associated protein 1

    Status: REVIEWED

    Source sequence(s)
    AL606906, BX545849
  5. NM_001430095.1NP_001417024.1  adenylyl cyclase-associated protein 1

    Status: REVIEWED

    Source sequence(s)
    AL606906, BX545849
  6. NM_001430096.1NP_001417025.1  adenylyl cyclase-associated protein 1

    Status: REVIEWED

    Source sequence(s)
    AL606906, BX545849
  7. NM_007598.6NP_031624.2  adenylyl cyclase-associated protein 1

    See identical proteins and their annotated locations for NP_031624.2

    Status: REVIEWED

    Source sequence(s)
    AL606906, BX545849
    Consensus CDS
    CCDS18604.1
    UniProtKB/Swiss-Prot
    P40124, Q8BPT7
    UniProtKB/TrEMBL
    Q3UVJ2
    Related
    ENSMUSP00000101862.2, ENSMUST00000106255.8
    Conserved Domains (2) summary
    pfam01213
    Location:561
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318472
    CAP_C; Adenylate cyclase associated (CAP) C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    122752841..122779869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)