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Conserved domains on  [gi|1844083968|ref|NP_006358|]
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adenylyl cyclase-associated protein 1 isoform a [Homo sapiens]

Protein Classification

adenylyl cyclase-associated protein( domain architecture ID 12014817)

adenylyl cyclase-associated family protein similar to Saccharomyces cerevisiae adenylyl cyclase-associated protein (CAP) which is a modular actin monomer binding protein that directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_C pfam08603
Adenylate cyclase associated (CAP) C terminal;
318-473 2.42e-91

Adenylate cyclase associated (CAP) C terminal;


:

Pssm-ID: 462532 [Multi-domain]  Cd Length: 157  Bit Score: 274.36  E-value: 2.42e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083968 318 EPAVLELEGKKWRVENQENVSNLVIEDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDV 397
Cdd:pfam08603   1 KPPKKELEGNKWIVENQENNKPIVIEDTEMNQSVYIFNCKNSTIQIKGKVNAISLDNCKKTSVVVDSLVSSVEVINCQSF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1844083968 398 KVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPT-EGGDFNEFPVPEQFKTLWNGQKLVTTVTEI 473
Cdd:pfam08603  81 QVQVLGKVPTISIDKTDGGQIYLSKESLDTEIVTSKSSEMNVNVPGgEDGDYVEFPIPEQFKTTIKDGKLVTEVVEH 157
CAP_N pfam01213
Adenylate cyclase associated (CAP) N terminal;
5-62 2.42e-12

Adenylate cyclase associated (CAP) N terminal;


:

Pssm-ID: 460113  Cd Length: 72  Bit Score: 62.00  E-value: 2.42e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1844083968   5 QNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAA--------------PYVQAFDSLLAGPVAEYLKIS 62
Cdd:pfam01213   1 TTLVKRLEAATSRLEDIAISASGSSASSSASSSGGGApsaaapapaaspapPSVEAFDELISGPVAPFVELS 72
 
Name Accession Description Interval E-value
CAP_C pfam08603
Adenylate cyclase associated (CAP) C terminal;
318-473 2.42e-91

Adenylate cyclase associated (CAP) C terminal;


Pssm-ID: 462532 [Multi-domain]  Cd Length: 157  Bit Score: 274.36  E-value: 2.42e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083968 318 EPAVLELEGKKWRVENQENVSNLVIEDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDV 397
Cdd:pfam08603   1 KPPKKELEGNKWIVENQENNKPIVIEDTEMNQSVYIFNCKNSTIQIKGKVNAISLDNCKKTSVVVDSLVSSVEVINCQSF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1844083968 398 KVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPT-EGGDFNEFPVPEQFKTLWNGQKLVTTVTEI 473
Cdd:pfam08603  81 QVQVLGKVPTISIDKTDGGQIYLSKESLDTEIVTSKSSEMNVNVPGgEDGDYVEFPIPEQFKTTIKDGKLVTEVVEH 157
CAP_N pfam01213
Adenylate cyclase associated (CAP) N terminal;
5-62 2.42e-12

Adenylate cyclase associated (CAP) N terminal;


Pssm-ID: 460113  Cd Length: 72  Bit Score: 62.00  E-value: 2.42e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1844083968   5 QNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAA--------------PYVQAFDSLLAGPVAEYLKIS 62
Cdd:pfam01213   1 TTLVKRLEAATSRLEDIAISASGSSASSSASSSGGGApsaaapapaaspapPSVEAFDELISGPVAPFVELS 72
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
394-431 2.72e-08

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 49.44  E-value: 2.72e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1844083968  394 SKDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVS 431
Cdd:smart00673   1 CESCTIQVSGKVNTISIDKCKKCSIYLGPVSGSPEIVN 38
 
Name Accession Description Interval E-value
CAP_C pfam08603
Adenylate cyclase associated (CAP) C terminal;
318-473 2.42e-91

Adenylate cyclase associated (CAP) C terminal;


Pssm-ID: 462532 [Multi-domain]  Cd Length: 157  Bit Score: 274.36  E-value: 2.42e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083968 318 EPAVLELEGKKWRVENQENVSNLVIEDTELKQVAYIYKCVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIINSKDV 397
Cdd:pfam08603   1 KPPKKELEGNKWIVENQENNKPIVIEDTEMNQSVYIFNCKNSTIQIKGKVNAISLDNCKKTSVVVDSLVSSVEVINCQSF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1844083968 398 KVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVSAKSSEMNVLIPT-EGGDFNEFPVPEQFKTLWNGQKLVTTVTEI 473
Cdd:pfam08603  81 QVQVLGKVPTISIDKTDGGQIYLSKESLDTEIVTSKSSEMNVNVPGgEDGDYVEFPIPEQFKTTIKDGKLVTEVVEH 157
CAP_N pfam01213
Adenylate cyclase associated (CAP) N terminal;
5-62 2.42e-12

Adenylate cyclase associated (CAP) N terminal;


Pssm-ID: 460113  Cd Length: 72  Bit Score: 62.00  E-value: 2.42e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1844083968   5 QNLVERLERAVGRLEAVSHTSDMHRGYADSPSKAGAA--------------PYVQAFDSLLAGPVAEYLKIS 62
Cdd:pfam01213   1 TTLVKRLEAATSRLEDIAISASGSSASSSASSSGGGApsaaapapaaspapPSVEAFDELISGPVAPFVELS 72
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
394-431 2.72e-08

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 49.44  E-value: 2.72e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1844083968  394 SKDVKVQVMGKVPTISINKTDGCHAYLSKNSLDCEIVS 431
Cdd:smart00673   1 CESCTIQVSGKVNTISIDKCKKCSIYLGPVSGSPEIVN 38
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
356-393 1.51e-07

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 47.51  E-value: 1.51e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1844083968  356 CVNTTLQIKGKINSITVDNCKKLGLVFDDVVGIVEIIN 393
Cdd:smart00673   1 CESCTIQVSGKVNTISIDKCKKCSIYLGPVSGSPEIVN 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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