U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TRIM38 tripartite motif containing 38 [ Homo sapiens (human) ]

    Gene ID: 10475, updated on 17-Jun-2024

    Summary

    Official Symbol
    TRIM38provided by HGNC
    Official Full Name
    tripartite motif containing 38provided by HGNC
    Primary source
    HGNC:HGNC:10059
    See related
    Ensembl:ENSG00000112343 AllianceGenome:HGNC:10059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF15; RORET
    Summary
    This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in spleen (RPKM 9.0), lymph node (RPKM 8.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIM38 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (25962802..25991231)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (25828703..25857166)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (25963030..25991459)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2B histone pseudogene 5 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:25898344-25898933 Neighboring gene solute carrier family 17 member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24170 Neighboring gene CRISPRi-validated cis-regulatory element chr6.1077 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:25971247-25972446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24171 Neighboring gene long intergenic non-protein coding RNA 2980 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:25999111-25999745 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:25999746-26000381 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26016208-26017207 Neighboring gene H3 histone pseudogene 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
    EBI GWAS Catalog
    Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC8946

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction HMP PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM38
    Names
    RING-type E3 ubiquitin transferase TRIM38
    Ro/SSA ribonucleoprotein homolog
    ring finger protein 15
    tripartite motif-containing protein 38
    zinc finger protein RoRet
    NP_006346.1
    XP_047274036.1
    XP_054210007.1
    XP_054210008.1
    XP_054210009.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006355.5NP_006346.1  E3 ubiquitin-protein ligase TRIM38

      See identical proteins and their annotated locations for NP_006346.1

      Status: REVIEWED

      Source sequence(s)
      AK313248, KC877159, U91328
      Consensus CDS
      CCDS4568.1
      UniProtKB/Swiss-Prot
      B2R862, O00635
      Related
      ENSP00000349596.2, ENST00000357085.5
      Conserved Domains (3) summary
      smart00336
      Location:88129
      BBOX; B-Box-type zinc finger
      cd15815
      Location:280461
      SPRY_PRY_TRIM38; PRY/SPRY domain of tripartite motif-binding protein 38 (TRIM38), also known as Ring finger protein 15 (RNF15)
      cd16600
      Location:1363
      RING-HC_TRIM38_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 38 (TRIM38) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      25962802..25991231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418080.1XP_047274036.1  E3 ubiquitin-protein ligase TRIM38 isoform X2

      UniProtKB/TrEMBL
      Q6MZQ5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      25828703..25857166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354032.1XP_054210007.1  E3 ubiquitin-protein ligase TRIM38 isoform X1

      UniProtKB/Swiss-Prot
      B2R862, O00635
    2. XM_054354034.1XP_054210009.1  E3 ubiquitin-protein ligase TRIM38 isoform X1

      UniProtKB/Swiss-Prot
      B2R862, O00635
    3. XM_054354033.1XP_054210008.1  E3 ubiquitin-protein ligase TRIM38 isoform X1

      UniProtKB/Swiss-Prot
      B2R862, O00635

    RNA

    1. XR_008487235.1 RNA Sequence