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    TOMM6 translocase of outer mitochondrial membrane 6 [ Homo sapiens (human) ]

    Gene ID: 100188893, updated on 17-Jun-2024

    Summary

    Official Symbol
    TOMM6provided by HGNC
    Official Full Name
    translocase of outer mitochondrial membrane 6provided by HGNC
    Primary source
    HGNC:HGNC:34528
    See related
    Ensembl:ENSG00000214736 MIM:616168; AllianceGenome:HGNC:34528
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OBTP; TOM6
    Summary
    Predicted to be involved in protein transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal (RPKM 63.4), kidney (RPKM 57.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TOMM6 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41787694..41789895)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (41616256..41618460)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41755432..41757633)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17194 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41755120-41756119 Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene Sharpr-MPRA regulatory region 15280 Neighboring gene ubiquitin specific peptidase 49 Neighboring gene small nucleolar RNA SNORA8 Neighboring gene MPRA-validated peak5805 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41861872-41862386 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:41862979-41863271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24529 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:41884515-41885714 Neighboring gene mediator complex subunit 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24530 Neighboring gene bystin like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32622, DKFZp761H221

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial outer membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of TOM complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial outer membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    mitochondrial import receptor subunit TOM6 homolog
    Names
    over-expressed breast tumor protein
    overexpressed breast tumor protein
    translocase of outer membrane 6 kDa subunit homolog
    translocase of outer mitochondrial membrane 6 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134493.2NP_001127965.1  mitochondrial import receptor subunit TOM6 homolog

      See identical proteins and their annotated locations for NP_001127965.1

      Status: REVIEWED

      Source sequence(s)
      AL365205
      Consensus CDS
      CCDS47424.1
      UniProtKB/Swiss-Prot
      B2DG15, Q96B49, Q9UH52
      Related
      ENSP00000381859.3, ENST00000398884.7
      Conserved Domains (1) summary
      pfam15184
      Location:174
      TOM6p; Mitochondrial import receptor subunit TOM6 homolog
    2. NM_001382294.1NP_001369223.1  mitochondrial import receptor subunit TOM6 homolog

      Status: REVIEWED

      Source sequence(s)
      AL365205
      Consensus CDS
      CCDS47424.1
      UniProtKB/Swiss-Prot
      B2DG15, Q96B49, Q9UH52
      Related
      ENSP00000381856.3, ENST00000398881.4
      Conserved Domains (1) summary
      pfam15184
      Location:174
      TOM6p; Mitochondrial import receptor subunit TOM6 homolog

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      41787694..41789895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      41616256..41618460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)