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PRICKLE4 prickle planar cell polarity protein 4 [ Homo sapiens (human) ]

Gene ID: 29964, updated on 1-Jun-2020

Summary

Official Symbol
PRICKLE4provided by HGNC
Official Full Name
prickle planar cell polarity protein 4provided by HGNC
Primary source
HGNC:HGNC:16805
See related
Ensembl:ENSG00000278224 MIM:611389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBTP; OEBT; TOMM6; C6orf49
Summary
C6ORF49 is a member of the LIM domain protein family (Teufel et al., 2005 [PubMed 15702247]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in spleen (RPKM 16.5), gall bladder (RPKM 14.1) and 23 other tissues See more
Orthologs

Genomic context

See PRICKLE4 in Genome Data Viewer
Location:
6p21.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (41780782..41787452)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41748500..41755110)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene progastricsin Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene translocase of outer mitochondrial membrane 6 Neighboring gene ubiquitin specific peptidase 49

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TOMM6

Homology

Clone Names

  • MGC120398

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
muscle alpha-actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Z disc IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
filamentous actin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
prickle-like protein 4
Names
over-expressed breast tumor protein
overexpressed breast tumor protein
overexpressed breast tumour protein
prickle homolog 4
translocase of outer mitochondrial membrane 6 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013397.6NP_037529.3  prickle-like protein 4

    Status: VALIDATED

    Source sequence(s)
    AL365205
    Consensus CDS
    CCDS34449.1
    UniProtKB/Swiss-Prot
    Q2TBC4
    Related
    ENSP00000404911.1, ENST00000458694.6
    Conserved Domains (3) summary
    cd09340
    Location:124181
    LIM1_Testin_like; The first LIM domain of Testin-like family
    cd09341
    Location:187242
    LIM2_Testin_like; The second LIM domain of Testin-like family
    cd09828
    Location:1116
    PET_OEBT; The PET domain of overexpressed breast tumor protein (OEBT)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    41780782..41787452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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