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    GRK2 G protein-coupled receptor kinase 2 [ Equus caballus (horse) ]

    Gene ID: 100059001, updated on 8-Mar-2024

    Summary

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    Official Symbol
    GRK2provided by VGNC
    Official Full Name
    G protein-coupled receptor kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:18594
    See related
    Ensembl:ENSECAG00000002944
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    103 current EquCab3.0 (GCF_002863925.1) 12 NC_009155.3 (30763623..30783221)
    102 previous assembly EquCab2.0 (GCF_000002305.2) 12 NC_009155.2 (27060294..27069444)

    Chromosome 12 - NC_009155.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102147408 Neighboring gene lysine demethylase 2A Neighboring gene ankyrin repeat domain 13D Neighboring gene slingshot protein phosphatase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of the force of heart contraction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-adrenergic receptor kinase 1
    Names
    adrenergic receptor beta kinase I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009155.3 Reference EquCab3.0 Primary Assembly

      Range
      30763623..30783221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023654545.1 → XP_023510313.1  beta-adrenergic receptor kinase 1 isoform X2

      UniProtKB/TrEMBL
      F6SK02
      Conserved Domains (3) summary
      cd08747
      Location:30 → 186
      RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
      cd01240
      Location:553 → 669
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      cl21453
      Location:185 → 530
      PKc_like; Protein Kinases, catalytic domain

    2. XM_023654544.1 → XP_023510312.1  beta-adrenergic receptor kinase 1 isoform X1

      UniProtKB/TrEMBL
      F6SK02
      Related
      ENSECAP00000003876.3, ENSECAT00000005502.3
      Conserved Domains (3) summary
      cd08747
      Location:30 → 186
      RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
      cd01240
      Location:553 → 670
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      cl21453
      Location:185 → 530
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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