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GRK2 G protein-coupled receptor kinase 2 [ Homo sapiens (human) ]

Gene ID: 156, updated on 21-Dec-2019

Summary

Official Symbol
GRK2provided by HGNC
Official Full Name
G protein-coupled receptor kinase 2provided by HGNC
Primary source
HGNC:HGNC:289
See related
Ensembl:ENSG00000173020 MIM:109635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BARK1; ADRBK1; BETA-ARK1
Summary
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]
Expression
Broad expression in bone marrow (RPKM 91.8), spleen (RPKM 61.9) and 24 other tissues See more
Orthologs

Genomic context

See GRK2 in Genome Data Viewer
Location:
11q13.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (67266420..67286556)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67033905..67054029)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984341 Neighboring gene lysine demethylase 2A Neighboring gene ankyrin repeat domain 13D Neighboring gene slingshot protein phosphatase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of adrenergic, beta, receptor kinase 1 (ADRBK1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
Knockdown of adrenergic, beta, receptor kinase 1 (ADRBK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16718

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Edg-2 lysophosphatidic acid receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
alpha-2A adrenergic receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
beta-adrenergic receptor kinase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled acetylcholine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
desensitization of G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of striated muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of the force of heart contraction by chemical signal IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of catecholamine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
tachykinin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cilium TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-adrenergic receptor kinase 1
Names
adrenergic beta receptor kinase 1
beta-ARK-1
NP_001610.2
XP_011543075.1
XP_024304144.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001619.5NP_001610.2  beta-adrenergic receptor kinase 1

    See identical proteins and their annotated locations for NP_001610.2

    Status: REVIEWED

    Source sequence(s)
    BC090863
    Consensus CDS
    CCDS8156.1
    UniProtKB/Swiss-Prot
    P25098
    UniProtKB/TrEMBL
    A0A0S2Z392
    Related
    ENSP00000312262.5, ENST00000308595.10
    Conserved Domains (3) summary
    cd08747
    Location:30186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:553670
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd14223
    Location:190510
    STKc_GRK2; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    67266420..67286556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544773.1XP_011543075.1  beta-adrenergic receptor kinase 1 isoform X2

    See identical proteins and their annotated locations for XP_011543075.1

    Conserved Domains (5) summary
    cd08747
    Location:8156
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:523640
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd14223
    Location:160480
    STKc_GRK2; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2
    pfam00069
    Location:161423
    Pkinase; Protein kinase domain
    pfam00169
    Location:530620
    PH; PH domain
  2. XM_024448376.1XP_024304144.1  beta-adrenergic receptor kinase 1 isoform X1

    Conserved Domains (3) summary
    cd08747
    Location:13161
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:528645
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd14223
    Location:165485
    STKc_GRK2; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2

RNA

  1. XR_001747779.1 RNA Sequence

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