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FGFBP1 fibroblast growth factor binding protein 1 [ Homo sapiens (human) ]

Gene ID: 9982, updated on 1-Aug-2020

Summary

Official Symbol
FGFBP1provided by HGNC
Official Full Name
fibroblast growth factor binding protein 1provided by HGNC
Primary source
HGNC:HGNC:19695
See related
Ensembl:ENSG00000137440 MIM:607737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FGFBP; HBP17; FGF-BP; FGF-BP1; FGFBP-1
Summary
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Expression
Biased expression in esophagus (RPKM 137.5), skin (RPKM 14.8) and 1 other tissue See more
Orthologs

Genomic context

See FGFBP1 in Genome Data Viewer
Location:
4p15.32
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (15935577..15938740, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (15937192..15940363, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene CD38 molecule Neighboring gene hypoxanthine phosphoribosyltransferase 1 pseudogene 1 Neighboring gene fibroblast growth factor binding protein 2 Neighboring gene prominin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat protein, but not HIV-1 Nef and gp120 proteins, competes with FGF-2 for binding to fibroblast growth factor binding protein 1 (FGF-BP1) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparin binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fibroblast growth factor-binding protein 1
Names
17 kDa HBGF-binding protein
17 kDa heparin-binding growth factor-binding protein
FGF-binding protein 1
heparin-binding growth factor binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005130.5NP_005121.1  fibroblast growth factor-binding protein 1 precursor

    See identical proteins and their annotated locations for NP_005121.1

    Status: REVIEWED

    Source sequence(s)
    AC005798, AK291307, AW959908, BC008910
    Consensus CDS
    CCDS3418.1
    UniProtKB/Swiss-Prot
    Q14512
    Related
    ENSP00000371770.1, ENST00000382333.2
    Conserved Domains (1) summary
    pfam06473
    Location:22231
    FGF-BP1; FGF binding protein 1 (FGF-BP1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    15935577..15938740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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