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Fgfbp1 fibroblast growth factor binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 14181, updated on 9-Oct-2022

Summary

Official Symbol
Fgfbp1provided by MGI
Official Full Name
fibroblast growth factor binding protein 1provided by MGI
Primary source
MGI:MGI:1096350
See related
Ensembl:ENSMUSG00000048373 AllianceGenome:MGI:1096350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FGF-BP; FGF-BP1; FGFBP-1
Summary
Enables fibroblast growth factor binding activity. Acts upstream of or within positive regulation of cell population proliferation and positive regulation of fibroblast growth factor receptor signaling pathway. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; brain; genitourinary system; meninges; and skin. Orthologous to human FGFBP1 (fibroblast growth factor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 24.0), stomach adult (RPKM 14.7) and 11 other tissues See more
Orthologs
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Genomic context

See Fgfbp1 in Genome Data Viewer
Location:
5; 5 B3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (44136200..44139173, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (43978858..43981828, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene apurinic/apyrimidinic endonuclease 2 pseudogene Neighboring gene ribosomal protein L15 pseudogene Neighboring gene prominin 1 Neighboring gene predicted gene, 35900

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fibroblast growth factor-binding protein 1
Names
FGF-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271616.1NP_001258545.1  fibroblast growth factor-binding protein 1 precursor

    See identical proteins and their annotated locations for NP_001258545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC164004, BC065774, CB524251, DV059653
    Consensus CDS
    CCDS19268.1
    UniProtKB/Swiss-Prot
    O70514, Q62399
    Related
    ENSMUSP00000142520.2, ENSMUST00000199894.2
    Conserved Domains (1) summary
    pfam06473
    Location:15247
    FGF-BP1; FGF binding protein 1 (FGF-BP1)
  2. NM_008009.4NP_032035.2  fibroblast growth factor-binding protein 1 precursor

    See identical proteins and their annotated locations for NP_032035.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC164004, BC065774, CB524251
    Consensus CDS
    CCDS19268.1
    UniProtKB/Swiss-Prot
    O70514, Q62399
    Related
    ENSMUSP00000056900.8, ENSMUST00000061299.9
    Conserved Domains (1) summary
    pfam06473
    Location:15247
    FGF-BP1; FGF binding protein 1 (FGF-BP1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    44136200..44139173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503711.5XP_006503774.1  fibroblast growth factor-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006503774.1

    UniProtKB/Swiss-Prot
    O70514, Q62399
    Conserved Domains (1) summary
    pfam06473
    Location:15247
    FGF-BP1; FGF binding protein 1 (FGF-BP1)
  2. XM_006503712.5XP_006503775.1  fibroblast growth factor-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006503775.1

    UniProtKB/Swiss-Prot
    O70514, Q62399
    Conserved Domains (1) summary
    pfam06473
    Location:15247
    FGF-BP1; FGF binding protein 1 (FGF-BP1)
  3. XM_030254129.2XP_030109989.1  fibroblast growth factor-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q62399
    Related
    ENSMUSP00000143011.2, ENSMUST00000199481.2
    Conserved Domains (1) summary
    pfam06473
    Location:15247
    FGF-BP1; FGF binding protein 1 (FGF-BP1)