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CDC42 cell division cycle 42 [ Homo sapiens (human) ]

Gene ID: 998, updated on 6-Sep-2020

Summary

Official Symbol
CDC42provided by HGNC
Official Full Name
cell division cycle 42provided by HGNC
Primary source
HGNC:HGNC:1736
See related
Ensembl:ENSG00000070831 MIM:116952
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TKS; G25K; CDC42Hs
Summary
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
Expression
Ubiquitous expression in bone marrow (RPKM 88.8), colon (RPKM 72.7) and 25 other tissues See more
Orthologs

Genomic context

See CDC42 in Genome Data Viewer
Location:
1p36.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (22052709..22101360)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (22379120..22419439)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chymotrypsin like elastase 3A Neighboring gene RNA, U6 small nuclear 776, pseudogene Neighboring gene long intergenic non-protein coding RNA 1635 Neighboring gene long intergenic non-protein coding RNA 339 Neighboring gene CDC42 antisense RNA 1 Neighboring gene MPHOSPH6 pseudogene 1 Neighboring gene Wnt family member 4 Neighboring gene uncharacterized LOC105376845 Neighboring gene uncharacterized LOC105376850

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
GeneReviews: Not available
Takenouchi-Kosaki syndrome
MedGen: C4225222 OMIM: 616737 GeneReviews: Not available
Compare labs

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 activates CDC42 in monocyte derived dendritic cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
env DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface subsequently activates Cdc42, Pak1, and Wasp, leading to an increase in membrane extensions at the DC surface PubMed
Nef nef HIV-1 Nef enhances the expression of CDC42 in human podocyte PubMed
nef The activation of Nef-associated kinase (NAK; also known as p21-activated kinase 1 or PAK1) by HIV-1 Nef is via the small GTPases Cdc42 and Rac1, suggesting an interaction between Nef and these GTPases PubMed
nef HIV-1 Nef inhibits the concomitant activation of the actin organizer N-Wasp by interfering with the translocation of N-Wasp to the cell periphery and blocks morphological changes induced by the known N-Wasp regulators Rac1 and Cdc42 PubMed
nef HIV-1 Nef treatment upregulates active CDC42 levels in dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GBD domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
apolipoprotein A-I receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
mitogen-activated protein kinase kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioesterase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell costimulation TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
PubMed 
actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament branching IEA
Inferred from Electronic Annotation
more info
 
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
adherens junction organization IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
cardiac conduction system development IEA
Inferred from Electronic Annotation
more info
 
cell junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
dendritic cell migration IEA
Inferred from Electronic Annotation
more info
 
dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
establishment of Golgi localization ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
PubMed 
filopodium assembly IEA
Inferred from Electronic Annotation
more info
 
heart contraction IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
macrophage differentiation TAS
Traceable Author Statement
more info
PubMed 
modification of synaptic structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of protein complex assembly IPI
Inferred from Physical Interaction
more info
PubMed 
neuron fate determination IEA
Inferred from Electronic Annotation
more info
 
neuropilin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear migration IEA
Inferred from Electronic Annotation
more info
 
organelle transport along microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of muscle cell differentiation TAS
Traceable Author Statement
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pinocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of pseudopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of synapse structural plasticity IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lamellipodium assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
regulation of modification of postsynaptic structure IEA
Inferred from Electronic Annotation
more info
 
regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
regulation of stress fiber assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
submandibular salivary gland formation IEA
Inferred from Electronic Annotation
more info
 
substantia nigra development HEP PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
viral RNA genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi transport complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
leading edge membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IEA
Inferred from Electronic Annotation
more info
 
spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
storage vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cell division control protein 42 homolog
Names
G25K GTP-binding protein
GTP binding protein, 25kDa
dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
growth-regulating protein
small GTP binding protein CDC42
NP_001034891.1
NP_001782.1
NP_426359.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047042.2 RefSeqGene

    Range
    5001..53652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039802.2NP_001034891.1  cell division control protein 42 homolog isoform 1 precursor

    See identical proteins and their annotated locations for NP_001034891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AL031281, BC018266
    Consensus CDS
    CCDS221.1
    UniProtKB/Swiss-Prot
    P60953
    UniProtKB/TrEMBL
    A0A024RAE4
    Related
    ENSP00000341072.3, ENST00000344548.7
    Conserved Domains (1) summary
    cd01874
    Location:3177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
  2. NM_001791.4NP_001782.1  cell division control protein 42 homolog isoform 1 precursor

    See identical proteins and their annotated locations for NP_001782.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1). Variants 1 and 3 encode the same isoform. Variants 1 and 2 encode isoforms that are the same length, but have distinct protein sequences.
    Source sequence(s)
    AL031281, AL121735, BC003682
    Consensus CDS
    CCDS221.1
    UniProtKB/Swiss-Prot
    P60953
    UniProtKB/TrEMBL
    A0A024RAE4
    Related
    ENSP00000499457.1, ENST00000656825.1
    Conserved Domains (1) summary
    cd01874
    Location:3177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
  3. NM_044472.3NP_426359.1  cell division control protein 42 homolog isoform 2

    See identical proteins and their annotated locations for NP_426359.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a novel 3' structure, resulting in a distinct 3' coding region compared to variant 1. The encoded isoform (2) is the same length as isoform 1 but has a distinct protein sequence.
    Source sequence(s)
    AL031281
    Consensus CDS
    CCDS222.1
    UniProtKB/Swiss-Prot
    P60953
    UniProtKB/TrEMBL
    A0A024RAE6
    Related
    ENSP00000314458.8, ENST00000315554.13
    Conserved Domains (1) summary
    cd01874
    Location:3177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    22052709..22101360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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