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Cdc42 cell division cycle 42 [ Mus musculus (house mouse) ]

Gene ID: 12540, updated on 8-Jan-2023

Summary

Official Symbol
Cdc42provided by MGI
Official Full Name
cell division cycle 42provided by MGI
Primary source
MGI:MGI:106211
See related
Ensembl:ENSMUSG00000006699 AllianceGenome:MGI:106211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables several functions, including GTP-dependent protein binding activity; GTPase activity; and Rho GDP-dissociation inhibitor binding activity. Involved in several processes, including dendritic spine morphogenesis; heart development; and positive regulation of cellular component organization. Acts upstream of or within several processes, including cellular response to interferon-gamma; filopodium assembly; and positive regulation of phosphatidylinositol 3-kinase activity. Located in several cellular components, including leading edge membrane; phagocytic vesicle; and storage vacuole. Is active in cell leading edge. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and immune system. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 107.5), placenta adult (RPKM 89.1) and 26 other tissues See more
Orthologs
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Genomic context

See Cdc42 in Genome Data Viewer
Location:
4 D3; 4 69.83 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (137047007..137085070, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (137319696..137357759, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31820 Neighboring gene chromobox homolog 5 pseudogene Neighboring gene wingless-type MMTV integration site family, member 4 Neighboring gene ribosomal protein L31, pseudogene 10 Neighboring gene predicted gene, 52681

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GBD domain binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables GTPase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables apolipoprotein A-I receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables thioesterase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Rho protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament branching ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adherens junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac conduction system development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dendritic cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endosomal transport TAS
Traceable Author Statement
more info
PubMed 
involved_in endothelin receptor signaling pathway involved in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of Golgi localization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of epithelial cell apical/basal polarity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within heart contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in modification of synaptic structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in modification of synaptic structure ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuropilin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nucleus localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in organelle transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
involved_in phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of pinocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synapse structural plasticity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of modification of postsynaptic structure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
part_of Golgi transport complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in leading edge membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
 
located_in storage vacuole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell division control protein 42 homolog
Names
G25K GTP-binding protein
cell division cycle 42 homolog
NP_001230698.1
NP_033991.1
XP_030108999.1
XP_030109000.1
XP_030109001.1
XP_030109002.1
XP_036019511.1
XP_036019512.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243769.1NP_001230698.1  cell division control protein 42 homolog isoform 2

    See identical proteins and their annotated locations for NP_001230698.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2, which is the same length but has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL645468, BF467211, CD353254, CD551112, L78075
    Consensus CDS
    CCDS57305.1
    UniProtKB/Swiss-Prot
    P60766
    UniProtKB/TrEMBL
    A0A6P5PDH9, A0A8C6MRC7
    Related
    ENSMUSP00000030417.10, ENSMUST00000030417.10
    Conserved Domains (1) summary
    cd01874
    Location:3177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
  2. NM_009861.3NP_033991.1  cell division control protein 42 homolog isoform 1

    See identical proteins and their annotated locations for NP_033991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AK168758, AL645468, BE685696, CD551112
    Consensus CDS
    CCDS18816.1
    UniProtKB/Swiss-Prot
    P60766, Q8BQ51
    UniProtKB/TrEMBL
    A0A6P5PJJ9, A0A8C6GI42
    Related
    ENSMUSP00000054634.7, ENSMUST00000051477.13
    Conserved Domains (1) summary
    cd01874
    Location:3177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    137047007..137085070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253140.2XP_030109000.1  cell division control protein 42 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8BQ51
    UniProtKB/TrEMBL
    A0A6P5PJJ9, A0A8C6GI42
    Conserved Domains (1) summary
    cd01874
    Location:3177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
  2. XM_030253142.1XP_030109002.1  cell division control protein 42 homolog isoform X2

    UniProtKB/TrEMBL
    A0A6P5PDH9, A0A8C6MRC7
    Conserved Domains (1) summary
    cd01874
    Location:3177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
  3. XM_030253139.2XP_030108999.1  cell division control protein 42 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8BQ51
    UniProtKB/TrEMBL
    A0A6P5PJJ9, A0A8C6GI42
    Conserved Domains (1) summary
    cd01874
    Location:3177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
  4. XM_030253141.2XP_030109001.1  cell division control protein 42 homolog isoform X2

    UniProtKB/TrEMBL
    A0A6P5PDH9, A0A8C6MRC7
    Conserved Domains (1) summary
    cd01874
    Location:3177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
  5. XM_036163618.1XP_036019511.1  cell division control protein 42 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8BQ51
    UniProtKB/TrEMBL
    A0A6P5PJJ9, A0A8C6GI42
    Conserved Domains (1) summary
    cd01874
    Location:3177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
  6. XM_036163619.1XP_036019512.1  cell division control protein 42 homolog isoform X2

    UniProtKB/TrEMBL
    A0A6P5PDH9, A0A8C6MRC7
    Conserved Domains (1) summary
    cd01874
    Location:3177
    Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family