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CDC25B cell division cycle 25B [ Homo sapiens (human) ]

Gene ID: 994, updated on 17-Jun-2019

Summary

Official Symbol
CDC25Bprovided by HGNC
Official Full Name
cell division cycle 25Bprovided by HGNC
Primary source
HGNC:HGNC:1726
See related
Ensembl:ENSG00000101224 MIM:116949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 21.4), appendix (RPKM 15.3) and 24 other tissues See more
Orthologs

Genomic context

See CDC25B in Genome Data Viewer
Location:
20p13
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (3786772..3806121)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3767419..3786765)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2213 Neighboring gene sperm flagellar 1 Neighboring gene centromere protein B Neighboring gene Sharpr-MPRA regulatory region 3723 Neighboring gene long intergenic non-protein coding RNA 1730 Neighboring gene nonconserved acetylation island sequence 110 enhancer Neighboring gene adaptor related protein complex 5 subunit sigma 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
NHGRI GWA Catalog
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Kinase Srk1 is required for the Vpr-mediated nuclear export of Cdc25 PubMed
vpr HIV-1 Vpr induces subcellular relocalization of Cdc25 from nuclear to cytoplasm and Vpr-induced nuclear exclusion of Cdc25 depends on the serine/threonine phosphorylation of Cdc25 and the presence of Rad24/14-3-3 protein PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphoprotein phosphatase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
female meiosis I IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
M-phase inducer phosphatase 2
Names
dual specificity phosphatase Cdc25B
NP_001274445.1
NP_001274446.1
NP_001274447.1
NP_001274448.1
NP_001274449.1
NP_001274451.1
NP_001274453.1
NP_004349.1
NP_068658.1
NP_068659.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029040.2 RefSeqGene

    Range
    13968..24350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001287516.1NP_001274445.1  M-phase inducer phosphatase 2 isoform 4

    See identical proteins and their annotated locations for NP_001274445.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at an upstream start codon, compared to variant 1. The resulting protein (isoform 4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK295573, AL109804, DA107932, DB477384
    Consensus CDS
    CCDS74700.1
    UniProtKB/TrEMBL
    B4DIG0
    Related
    ENSP00000339125.6, ENST00000344256.10
    Conserved Domains (2) summary
    cd01530
    Location:348467
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:49319
    M-inducer_phosp; M-phase inducer phosphatase
  2. NM_001287517.1NP_001274446.1  M-phase inducer phosphatase 2 isoform 5

    See identical proteins and their annotated locations for NP_001274446.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR which results in initiation of translation at an upstream start codon, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK299192, AL109804, DA107932, DB477384
    UniProtKB/TrEMBL
    B4DRC3
    Conserved Domains (2) summary
    cd01530
    Location:334453
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:35305
    M-inducer_phosp; M-phase inducer phosphatase
  3. NM_001287518.1NP_001274447.1  M-phase inducer phosphatase 2 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, initiates translation at an upstream start codon, and lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 6) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK299028, AL109804, DA107932, DB477384
    Consensus CDS
    CCDS74701.1
    UniProtKB/TrEMBL
    B4DQZ3, G8JLH2
    Related
    ENSP00000368918.5, ENST00000379598.9
    Conserved Domains (2) summary
    cd01530
    Location:321440
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:49292
    M-inducer_phosp; M-phase inducer phosphatase
  4. NM_001287519.1NP_001274448.1  M-phase inducer phosphatase 2 isoform 7

    See identical proteins and their annotated locations for NP_001274448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 5' UTR which results in initiation of translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 7) has a shorter N-terminus compared to isoform 1. Variants 7 and 8 encode the same isoform.
    Source sequence(s)
    AL109804, AL561439, BC051711, BM793120, BX647988, DA107932
    UniProtKB/Swiss-Prot
    P30305
    UniProtKB/TrEMBL
    B3KS38
    Conserved Domains (2) summary
    cd01530
    Location:300419
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:1271
    M-inducer_phosp; M-phase inducer phosphatase
  5. NM_001287520.1NP_001274449.1  M-phase inducer phosphatase 2 isoform 7

    See identical proteins and their annotated locations for NP_001274449.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as CDC25B6, uses an alternate splice site in the 5' UTR which results in initiation of translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 7) has a shorter N-terminus compared to isoform 1. Variants 7 and 8 encode the same isoform.
    Source sequence(s)
    DA107932, FR695900
    UniProtKB/TrEMBL
    B3KS38
    Conserved Domains (2) summary
    cd01530
    Location:300419
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:1271
    M-inducer_phosp; M-phase inducer phosphatase
  6. NM_001287522.1NP_001274451.1  M-phase inducer phosphatase 2 isoform 8

    See identical proteins and their annotated locations for NP_001274451.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses an alternate splice site in the 5' UTR which results in initiation of translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 8) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL561439, DA107932, FR695901
    UniProtKB/TrEMBL
    E1YMX4
    Conserved Domains (2) summary
    cd01530
    Location:259378
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:1230
    M-inducer_phosp; M-phase inducer phosphatase
  7. NM_001287524.1NP_001274453.1  M-phase inducer phosphatase 2 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, which causes translation initiation at a downstream start codon. The resulting protein (isoform 9) has a shorter N-terminus and lacks an internal region compared to isoform 1.
    Source sequence(s)
    BC051711, BX640836, DA065196, DA107932
    UniProtKB/Swiss-Prot
    P30305
    UniProtKB/TrEMBL
    Q6MZW8
    Conserved Domains (2) summary
    cd01530
    Location:220339
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:3191
    M-inducer_phosp; M-phase inducer phosphatase
  8. NM_004358.4NP_004349.1  M-phase inducer phosphatase 2 isoform 2

    See identical proteins and their annotated locations for NP_004349.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as CDC25B1, uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AK092713, BC051711, BX640836, DA107932, S78187
    Consensus CDS
    CCDS13065.1
    UniProtKB/Swiss-Prot
    P30305
    UniProtKB/TrEMBL
    B3KS38, Q6MZW8
    Related
    ENSP00000405972.2, ENST00000439880.6
    Conserved Domains (2) summary
    cd01530
    Location:398517
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:99369
    M-inducer_phosp; M-phase inducer phosphatase
  9. NM_021872.3NP_068658.1  M-phase inducer phosphatase 2 isoform 3

    See identical proteins and their annotated locations for NP_068658.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as CDC25B2, lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 3) compared to isoform 1.
    Source sequence(s)
    AK092713, BC051711, BX640836, DA107932, S78187, Z68092
    Consensus CDS
    CCDS13066.1
    UniProtKB/Swiss-Prot
    P30305
    UniProtKB/TrEMBL
    B3KS38, Q6MZW8
    Related
    ENSP00000339170.4, ENST00000340833.4
    Conserved Domains (2) summary
    cd01530
    Location:371490
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:113342
    M-inducer_phosp; M-phase inducer phosphatase
  10. NM_021873.3NP_068659.1  M-phase inducer phosphatase 2 isoform 1

    See identical proteins and their annotated locations for NP_068659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as CDC25B3, represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK092713, BC051711, BX640836, DA107932, S78187
    Consensus CDS
    CCDS13067.1
    UniProtKB/Swiss-Prot
    P30305
    UniProtKB/TrEMBL
    B3KS38, Q6MZW8
    Related
    ENSP00000245960.5, ENST00000245960.9
    Conserved Domains (2) summary
    cd01530
    Location:412531
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:113383
    M-inducer_phosp; M-phase inducer phosphatase

RNA

  1. NR_136335.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109804, DA107932, FR695900
  2. NR_136336.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109804, DA107932, DB477384

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    3786772..3806121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_937181.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021874.2: Suppressed sequence

    Description
    NM_021874.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_212530.1: Suppressed sequence

    Description
    NM_212530.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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