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Cdc25b cell division cycle 25B [ Mus musculus (house mouse) ]

Gene ID: 12531, updated on 11-Apr-2024

Summary

Official Symbol
Cdc25bprovided by MGI
Official Full Name
cell division cycle 25Bprovided by MGI
Primary source
MGI:MGI:99701
See related
Ensembl:ENSMUSG00000027330 AllianceGenome:MGI:99701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Acts upstream of or within female meiosis I; oocyte maturation; and positive regulation of protein kinase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including 1-cell stage embryo; gonad; liver; placenta; and primitive collecting duct. Orthologous to human CDC25B (cell division cycle 25B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 81.1), liver E14 (RPKM 67.6) and 22 other tissues See more
Orthologs
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Genomic context

See Cdc25b in Genome Data Viewer
Location:
2 F1; 2 63.29 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131028356..131040431)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131186436..131198511)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sperm flagellar 1 Neighboring gene centromere protein B Neighboring gene STARR-positive B cell enhancer mm9_chr2:131026522-131026822 Neighboring gene STARR-positive B cell enhancer ABC_E10146 Neighboring gene adaptor-related protein 5 complex, sigma 1 subunit Neighboring gene STARR-seq mESC enhancer starr_05703 Neighboring gene STARR-positive B cell enhancer ABC_E4499 Neighboring gene mitochondrial antiviral signaling protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within female meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell cycle G2/M phase transition IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
M-phase inducer phosphatase 2
Names
dual specificity phosphatase Cdc25B
NP_001104545.1
NP_075606.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111075.4NP_001104545.1  M-phase inducer phosphatase 2 isoform b

    See identical proteins and their annotated locations for NP_001104545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame coding exon and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL808128, AL831736, BC057568
    Consensus CDS
    CCDS50717.1
    UniProtKB/TrEMBL
    Q3TZX9, Q9DBN8
    Related
    ENSMUSP00000078784.9, ENSMUST00000079857.9
    Conserved Domains (2) summary
    cd01530
    Location:382501
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:111353
    M-inducer_phosp; M-phase inducer phosphatase
  2. NM_023117.4NP_075606.1  M-phase inducer phosphatase 2 isoform a

    See identical proteins and their annotated locations for NP_075606.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL808128, AL831736, BC057568, BQ561430, W54021
    Consensus CDS
    CCDS16758.1
    UniProtKB/Swiss-Prot
    P30306, Q99LP3
    UniProtKB/TrEMBL
    Q3TZX9, Q3U535
    Related
    ENSMUSP00000028804.9, ENSMUST00000028804.15
    Conserved Domains (2) summary
    cd01530
    Location:408527
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:111379
    M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    131028356..131040431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_374398.2 RNA Sequence