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P2RY14 purinergic receptor P2Y14 [ Homo sapiens (human) ]

Gene ID: 9934, updated on 1-Jun-2020

Summary

Official Symbol
P2RY14provided by HGNC
Official Full Name
purinergic receptor P2Y14provided by HGNC
Primary source
HGNC:HGNC:16442
See related
Ensembl:ENSG00000174944 MIM:610116
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2Y14; BPR105; GPR105
Summary
The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in esophagus (RPKM 4.9), placenta (RPKM 4.7) and 18 other tissues See more
Orthologs

Genomic context

See P2RY14 in Genome Data Viewer
Location:
3q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (151212115..151279167, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150929905..150996996, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene RNA, 5S ribosomal pseudogene 145 Neighboring gene G protein-coupled receptor 171 Neighboring gene SET pseudogene 11 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of purinergic receptor P2Y, G-protein coupled, 14 (P2RY14) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0001

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
UDP-activated nucleotide receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
P2Y purinoceptor 14
Names
G protein coupled receptor for UDP-glucose
G-protein coupled receptor 105
P2Y(14) receptor
P2Y14 receptor
UDP-glucose receptor
purinergic receptor P2Y, G-protein coupled, 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081455.2NP_001074924.1  P2Y purinoceptor 14

    See identical proteins and their annotated locations for NP_001074924.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC078816, BC034989, CD110153
    Consensus CDS
    CCDS3156.1
    UniProtKB/Swiss-Prot
    Q15391
    UniProtKB/TrEMBL
    A5JUU3
    Related
    ENSP00000408733.2, ENST00000424796.6
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34235
    7tm_4; Olfactory receptor
  2. NM_014879.4NP_055694.3  P2Y purinoceptor 14

    See identical proteins and their annotated locations for NP_055694.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC078816, BC034989
    Consensus CDS
    CCDS3156.1
    UniProtKB/Swiss-Prot
    Q15391
    UniProtKB/TrEMBL
    A5JUU3
    Related
    ENSP00000308361.3, ENST00000309170.8
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34235
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    151212115..151279167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513340.3XP_011511642.1  P2Y purinoceptor 14 isoform X1

    See identical proteins and their annotated locations for XP_011511642.1

    UniProtKB/Swiss-Prot
    Q15391
    UniProtKB/TrEMBL
    A5JUU3
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34235
    7tm_4; Olfactory receptor
  2. XM_017007583.2XP_016863072.1  P2Y purinoceptor 14 isoform X1

    UniProtKB/Swiss-Prot
    Q15391
    UniProtKB/TrEMBL
    A5JUU3
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34235
    7tm_4; Olfactory receptor
  3. XM_005247922.3XP_005247979.1  P2Y purinoceptor 14 isoform X1

    See identical proteins and their annotated locations for XP_005247979.1

    UniProtKB/Swiss-Prot
    Q15391
    UniProtKB/TrEMBL
    A5JUU3
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34235
    7tm_4; Olfactory receptor
  4. XM_005247923.3XP_005247980.1  P2Y purinoceptor 14 isoform X1

    See identical proteins and their annotated locations for XP_005247980.1

    UniProtKB/Swiss-Prot
    Q15391
    UniProtKB/TrEMBL
    A5JUU3
    Conserved Domains (2) summary
    pfam00001
    Location:40295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34235
    7tm_4; Olfactory receptor
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