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HELZ helicase with zinc finger [ Homo sapiens (human) ]

Gene ID: 9931, updated on 21-Dec-2019

Summary

Official Symbol
HELZprovided by HGNC
Official Full Name
helicase with zinc fingerprovided by HGNC
Primary source
HGNC:HGNC:16878
See related
Ensembl:ENSG00000198265 MIM:606699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHRC; DRHC; HUMORF5
Summary
HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 6.5), ovary (RPKM 6.3) and 25 other tissues See more
Orthologs

Genomic context

See HELZ in Genome Data Viewer
Location:
17q24.2
Exon count:
36
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (67070444..67245989, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (65066554..65241349, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 4 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 1 Neighboring gene Sharpr-MPRA regulatory region 4721 Neighboring gene ribosomal protein L36a pseudogene 48 Neighboring gene uncharacterized LOC101928021 Neighboring gene RNA, 5S ribosomal pseudogene 447 Neighboring gene proteasome 26S subunit, non-ATPase 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0054, MGC163454, DKFZp586G1924

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
posttranscriptional gene silencing by RNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
P granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable helicase with zinc finger domain
Names
down-regulated in human cancers protein
helicase with zinc finger domain
NP_001317376.2
NP_055692.3
XP_005257945.1
XP_006722277.1
XP_006722278.1
XP_006722279.1
XP_011523846.1
XP_016880966.1
XP_016880967.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330447.2NP_001317376.2  probable helicase with zinc finger domain isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005544, AC007448
    Consensus CDS
    CCDS82192.1
    Related
    ENSP00000464512.1, ENST00000580168.5
  2. NM_014877.4NP_055692.3  probable helicase with zinc finger domain isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005544, AC007448
    Consensus CDS
    CCDS42374.1
    Related
    ENSP00000351524.5, ENST00000358691.10
    Conserved Domains (3) summary
    pfam00642
    Location:181205
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl22977
    Location:8401051
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl26261
    Location:6361074
    AAA_11; AAA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    67070444..67245989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525544.2XP_011523846.1  probable helicase with zinc finger domain isoform X1

    See identical proteins and their annotated locations for XP_011523846.1

    Conserved Domains (6) summary
    PHA03160
    Location:16561815
    PHA03160; hypothetical protein; Provisional
    COG1112
    Location:7851099
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam00642
    Location:181205
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13086
    Location:669861
    AAA_11; AAA domain
    cl21455
    Location:669766
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:8681079
    UvrD_C_2; UvrD-like helicase C-terminal domain
  2. XM_006722215.3XP_006722278.1  probable helicase with zinc finger domain isoform X3

    Conserved Domains (5) summary
    PHA03160
    Location:14211580
    PHA03160; hypothetical protein; Provisional
    COG1112
    Location:550864
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13086
    Location:434626
    AAA_11; AAA domain
    cl21455
    Location:434531
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:633844
    UvrD_C_2; UvrD-like helicase C-terminal domain
  3. XM_017025478.1XP_016880967.1  probable helicase with zinc finger domain isoform X6

  4. XM_017025477.2XP_016880966.1  probable helicase with zinc finger domain isoform X4

  5. XM_005257888.5XP_005257945.1  probable helicase with zinc finger domain isoform X2

    Conserved Domains (6) summary
    PHA03160
    Location:16551814
    PHA03160; hypothetical protein; Provisional
    COG1112
    Location:7841098
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam00642
    Location:181205
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13086
    Location:669860
    AAA_11; AAA domain
    cl21455
    Location:669765
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:8671078
    UvrD_C_2; UvrD-like helicase C-terminal domain
  6. XM_006722214.4XP_006722277.1  probable helicase with zinc finger domain isoform X1

    See identical proteins and their annotated locations for XP_006722277.1

    Conserved Domains (6) summary
    PHA03160
    Location:16561815
    PHA03160; hypothetical protein; Provisional
    COG1112
    Location:7851099
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam00642
    Location:181205
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13086
    Location:669861
    AAA_11; AAA domain
    cl21455
    Location:669766
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:8681079
    UvrD_C_2; UvrD-like helicase C-terminal domain
  7. XM_006722216.3XP_006722279.1  probable helicase with zinc finger domain isoform X5

    Conserved Domains (4) summary
    COG1112
    Location:393707
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13086
    Location:277469
    AAA_11; AAA domain
    cl21455
    Location:277374
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:476687
    UvrD_C_2; UvrD-like helicase C-terminal domain

RNA

  1. XR_001752714.2 RNA Sequence

  2. XR_001752713.2 RNA Sequence

  3. XR_001752712.2 RNA Sequence

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