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Helz helicase with zinc finger domain [ Mus musculus (house mouse) ]

Gene ID: 78455, updated on 17-Aug-2024

Summary

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Official Symbol
Helzprovided by MGI
Official Full Name
helicase with zinc finger domainprovided by MGI
Primary source
MGI:MGI:1925705
See related
Ensembl:ENSMUSG00000020721 AllianceGenome:MGI:1925705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DRHC; 3110078M01Rik; 9430093I07Rik; 9630002H22Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in post-transcriptional gene silencing by RNA. Predicted to be located in nucleus. Predicted to be active in P granule and cytosol. Is expressed in retina outer nuclear layer. Orthologous to human HELZ (helicase with zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.0), placenta adult (RPKM 5.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E1; 11 70.29 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (107437789..107584652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (107546963..107693826)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:107340564-107340865 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 Neighboring gene STARR-seq mESC enhancer starr_30988 Neighboring gene RIKEN cDNA A830035A12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107390700-107390809 Neighboring gene STARR-seq mESC enhancer starr_30991 Neighboring gene predicted gene, 39426 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107434682-107434883 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107436638-107436803 Neighboring gene STARR-seq mESC enhancer starr_30994 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:107505802-107506005 Neighboring gene microRNA 6932 Neighboring gene calcium channel, voltage-dependent, gamma subunit 1 Neighboring gene calcium channel, voltage-dependent, gamma subunit 4 Neighboring gene VISTA enhancer mm1348 Neighboring gene predicted gene 11650

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CircHelz activates NLRP3 inflammasome to promote myocardial injury by sponging miR-133a-3p in mouse ischemic heart. Bian Y, et al. J Mol Cell Cardiol, 2021 Sep. PMID 34043986
  2. Identification of a differentially expressed RNA helicase by gene trapping. Wagner DS, et al. Biochem Biophys Res Commun, 1999 Sep 7. PMID 10471385
  3. The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation. Hasgall PA, et al. PLoS One, 2011. PMID 21765940, Free PMC Article
  4. Cardiac deletion of Smyd2 is dispensable for mouse heart development. Diehl F, et al. PLoS One, 2010 Mar 17. PMID 20305823, Free PMC Article
  5. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircHelz activates NLRP3 inflammasome to promote myocardial injury by sponging miR-133a-3p in mouse ischemic heart.
    Title: CircHelz activates NLRP3 inflammasome to promote myocardial injury by sponging miR-133a-3p in mouse ischemic heart.
  2. Downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6.
    Title: The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation.
  3. Smyd2, similar to Smyd3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ
    Title: Cardiac deletion of Smyd2 is dispensable for mouse heart development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0054

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable helicase with zinc finger domain
NP_001355684.1
NP_938040.1
XP_006534567.1
XP_006534568.1
XP_006534569.1
XP_030102290.1
XP_036012985.1
XP_036012986.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368755.1 → NP_001355684.1  probable helicase with zinc finger domain isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645947
    Consensus CDS
    CCDS88275.1
    UniProtKB/Swiss-Prot
    A1L4L4, A2AAU4, Q6DFV5, Q8BZZ6, Q8CHI3, Q8VDI3
    Related
    ENSMUSP00000102357.2, ENSMUST00000106746.8
    Conserved Domains (5) summary
    smart00818
    Location:1337 → 1413
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    cd18808
    Location:868 → 1068
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18077
    Location:641 → 867
    DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
    pfam00642
    Location:181 → 204
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam03154
    Location:1261 → 1415
    Atrophin-1; Atrophin-1 family

  2. NM_198298.2 → NP_938040.1  probable helicase with zinc finger domain isoform 1

    See identical proteins and their annotated locations for NP_938040.1

    Status: VALIDATED

    Source sequence(s)
    AL645947
    Consensus CDS
    CCDS25569.1
    UniProtKB/Swiss-Prot
    Q6DFV5
    UniProtKB/TrEMBL
    A0A0R4J0Y3
    Related
    ENSMUSP00000074533.2, ENSMUST00000075012.8
    Conserved Domains (5) summary
    smart00818
    Location:1338 → 1414
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    cd18808
    Location:869 → 1069
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18077
    Location:641 → 868
    DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
    pfam00642
    Location:181 → 204
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam03154
    Location:1262 → 1416
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    107437789..107584652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534505.5 → XP_006534568.1  probable helicase with zinc finger domain isoform X1

    See identical proteins and their annotated locations for XP_006534568.1

    UniProtKB/Swiss-Prot
    Q6DFV5
    UniProtKB/TrEMBL
    A0A0R4J0Y3
    Conserved Domains (5) summary
    smart00818
    Location:1338 → 1414
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    cd18808
    Location:869 → 1069
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18077
    Location:641 → 868
    DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
    pfam00642
    Location:181 → 204
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam03154
    Location:1262 → 1416
    Atrophin-1; Atrophin-1 family

  2. XM_006534506.5 → XP_006534569.1  probable helicase with zinc finger domain isoform X1

    See identical proteins and their annotated locations for XP_006534569.1

    UniProtKB/Swiss-Prot
    Q6DFV5
    UniProtKB/TrEMBL
    A0A0R4J0Y3
    Conserved Domains (5) summary
    smart00818
    Location:1338 → 1414
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    cd18808
    Location:869 → 1069
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18077
    Location:641 → 868
    DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
    pfam00642
    Location:181 → 204
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam03154
    Location:1262 → 1416
    Atrophin-1; Atrophin-1 family

  3. XM_006534504.1 → XP_006534567.1  probable helicase with zinc finger domain isoform X1

    See identical proteins and their annotated locations for XP_006534567.1

    UniProtKB/Swiss-Prot
    Q6DFV5
    UniProtKB/TrEMBL
    A0A0R4J0Y3
    Conserved Domains (5) summary
    smart00818
    Location:1338 → 1414
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    cd18808
    Location:869 → 1069
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18077
    Location:641 → 868
    DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
    pfam00642
    Location:181 → 204
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam03154
    Location:1262 → 1416
    Atrophin-1; Atrophin-1 family

  4. XM_036157092.1 → XP_036012985.1  probable helicase with zinc finger domain isoform X3

    Conserved Domains (4) summary
    cd18808
    Location:834 → 1034
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    pfam00642
    Location:181 → 205
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam03154
    Location:1143 → 1374
    Atrophin-1; Atrophin-1 family
    cl28899
    Location:641 → 833
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  5. XM_030246430.1 → XP_030102290.1  probable helicase with zinc finger domain isoform X2

    UniProtKB/Swiss-Prot
    A1L4L4, A2AAU4, Q6DFV5, Q8BZZ6, Q8CHI3, Q8VDI3
    Related
    ENSMUSP00000097878.2, ENSMUST00000100305.8
    Conserved Domains (5) summary
    smart00818
    Location:1337 → 1413
    Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
    cd18808
    Location:868 → 1068
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18077
    Location:641 → 867
    DEXXQc_HELZ; DEXXQ-box helicase domain of HELZ
    pfam00642
    Location:181 → 204
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam03154
    Location:1261 → 1415
    Atrophin-1; Atrophin-1 family

  6. XM_036157093.1 → XP_036012986.1  probable helicase with zinc finger domain isoform X3

    Conserved Domains (4) summary
    cd18808
    Location:834 → 1034
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    pfam00642
    Location:181 → 205
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam03154
    Location:1143 → 1374
    Atrophin-1; Atrophin-1 family
    cl28899
    Location:641 → 833
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DFV5.2 GenPept UniProtKB/Swiss-Prot:Q6DFV5

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