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CDC25A cell division cycle 25A [ Homo sapiens (human) ]

Gene ID: 993, updated on 1-Jun-2020

Summary

Official Symbol
CDC25Aprovided by HGNC
Official Full Name
cell division cycle 25Aprovided by HGNC
Primary source
HGNC:HGNC:1725
See related
Ensembl:ENSG00000164045 MIM:116947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC25A2
Summary
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 7.4), bone marrow (RPKM 4.6) and 15 other tissues See more
Orthologs

Genomic context

See CDC25A in Genome Data Viewer
Location:
3p21.31
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (48157146..48188417, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48198668..48230153, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 664, pseudogene Neighboring gene ribosomal protein L17 pseudogene 16 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 4 Neighboring gene RNA, U7 small nuclear 128 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 pseudogene 1 Neighboring gene microRNA 4443 Neighboring gene cathelicidin antimicrobial peptide

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Kinase Srk1 is required for the Vpr-mediated nuclear export of Cdc25 PubMed
vpr HIV-1 Vpr induces subcellular relocalization of Cdc25 from nuclear to cytoplasm and Vpr-induced nuclear exclusion of Cdc25 depends on the serine/threonine phosphorylation of Cdc25 and the presence of Rad24/14-3-3 protein PubMed
Vpu vpu HIV-1 Vpu stabilizes cellular Cdc25A and differentially affects betaTrCP-mediated degradation events at different phases of the cell cycle PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphoprotein phosphatase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of cell cycle TAS
Traceable Author Statement
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
response to radiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
M-phase inducer phosphatase 1
Names
CDC25 isoform A1-CAG
CDC25A2-CAG isoform
dual specificity phosphatase CDC25A
NP_001780.2
NP_963861.1
XP_006713497.1
XP_006713498.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001789.3NP_001780.2  M-phase inducer phosphatase 1 isoform a

    See identical proteins and their annotated locations for NP_001780.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC104190, AC124916, AI917350, BC007401, BQ065803, BX392016
    Consensus CDS
    CCDS2760.1
    UniProtKB/Swiss-Prot
    P30304
    UniProtKB/TrEMBL
    A0A024R2S4
    Related
    ENSP00000303706.3, ENST00000302506.8
    Conserved Domains (2) summary
    cd01530
    Location:357475
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:86328
    M-inducer_phosp; M-phase inducer phosphatase
  2. NM_201567.2NP_963861.1  M-phase inducer phosphatase 1 isoform b

    See identical proteins and their annotated locations for NP_963861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC104190, AC124916, AI917350, AY137580, BC007401, BQ065803, BX392016
    Consensus CDS
    CCDS2761.1
    UniProtKB/Swiss-Prot
    P30304
    UniProtKB/TrEMBL
    A0A024R2R6
    Related
    ENSP00000343166.3, ENST00000351231.7
    Conserved Domains (2) summary
    cd01530
    Location:317435
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:86288
    M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    48157146..48188417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713435.3XP_006713498.1  M-phase inducer phosphatase 1 isoform X2

    See identical proteins and their annotated locations for XP_006713498.1

    UniProtKB/TrEMBL
    D8KXX0
    Conserved Domains (2) summary
    cd01530
    Location:316434
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:86287
    M-inducer_phosp; M-phase inducer phosphatase
  2. XM_006713434.3XP_006713497.1  M-phase inducer phosphatase 1 isoform X1

    See identical proteins and their annotated locations for XP_006713497.1

    UniProtKB/TrEMBL
    K7N7S0
    Conserved Domains (2) summary
    cd01530
    Location:356474
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:86327
    M-inducer_phosp; M-phase inducer phosphatase

RNA

  1. XR_001740392.2 RNA Sequence

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