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CDC25A cell division cycle 25A [ Homo sapiens (human) ]

Gene ID: 993, updated on 9-Oct-2022

Summary

Official Symbol
CDC25Aprovided by HGNC
Official Full Name
cell division cycle 25Aprovided by HGNC
Primary source
HGNC:HGNC:1725
See related
Ensembl:ENSG00000164045 MIM:116947; AllianceGenome:HGNC:1725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC25A2
Summary
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 7.4), bone marrow (RPKM 4.6) and 15 other tissues See more
Orthologs
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Genomic context

See CDC25A in Genome Data Viewer
Location:
3p21.31
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (48157146..48188417, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (48184306..48215589, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48198636..48229907, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 664, pseudogene Neighboring gene ribosomal protein L17 pseudogene 16 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 4 Neighboring gene RNA, U7 small nuclear 128 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 pseudogene 1 Neighboring gene microRNA 4443 Neighboring gene Sharpr-MPRA regulatory region 12857

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Kinase Srk1 is required for the Vpr-mediated nuclear export of Cdc25 PubMed
vpr HIV-1 Vpr induces subcellular relocalization of Cdc25 from nuclear to cytoplasm and Vpr-induced nuclear exclusion of Cdc25 depends on the serine/threonine phosphorylation of Cdc25 and the presence of Rad24/14-3-3 protein PubMed
Vpu vpu HIV-1 Vpu stabilizes cellular Cdc25A and differentially affects betaTrCP-mediated degradation events at different phases of the cell cycle PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphoprotein phosphatase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
M-phase inducer phosphatase 1
Names
CDC25 homolog A
dual specificity phosphatase CDC25A
NP_001780.2
NP_963861.1
XP_047305319.1
XP_047305320.1
XP_047305321.1
XP_047305322.1
XP_047305323.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001789.3NP_001780.2  M-phase inducer phosphatase 1 isoform a

    See identical proteins and their annotated locations for NP_001780.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC104190, AC124916, AI917350, BC007401, BQ065803, BX392016
    Consensus CDS
    CCDS2760.1
    UniProtKB/Swiss-Prot
    P30304, Q9H2F2
    UniProtKB/TrEMBL
    A0A024R2S4
    Related
    ENSP00000303706.3, ENST00000302506.8
    Conserved Domains (2) summary
    cd01530
    Location:357475
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:86328
    M-inducer_phosp; M-phase inducer phosphatase
  2. NM_201567.2NP_963861.1  M-phase inducer phosphatase 1 isoform b

    See identical proteins and their annotated locations for NP_963861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC104190, AC124916, AI917350, AY137580, BC007401, BQ065803, BX392016
    Consensus CDS
    CCDS2761.1
    UniProtKB/Swiss-Prot
    P30304
    UniProtKB/TrEMBL
    A0A024R2R6
    Related
    ENSP00000343166.3, ENST00000351231.7
    Conserved Domains (2) summary
    cd01530
    Location:317435
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:86288
    M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    48157146..48188417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449366.1XP_047305322.1  M-phase inducer phosphatase 1 isoform X4

    UniProtKB/TrEMBL
    D8KXX0
  2. XM_047449364.1XP_047305320.1  M-phase inducer phosphatase 1 isoform X2

    UniProtKB/TrEMBL
    K7N7S0
  3. XM_047449365.1XP_047305321.1  M-phase inducer phosphatase 1 isoform X3

    UniProtKB/TrEMBL
    A0A024R2R6
  4. XM_047449363.1XP_047305319.1  M-phase inducer phosphatase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9H2F2
  5. XM_047449367.1XP_047305323.1  M-phase inducer phosphatase 1 isoform X5

    Related
    ENSP00000416483.1, ENST00000443342.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    48184306..48215589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)