Cdc25a cell division cycle 25A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc25aprovided by MGI
Official Full Name: cell division cycle 25Aprovided by MGI
Primary source: MGI:MGI:103198
See related: Ensembl:ENSMUSG00000032477 AllianceGenome:MGI:103198
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D9Ertd393e
Summary: Predicted to enable chaperone binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including mitotic cell cycle phase transition; positive regulation of cell cycle G2/M phase transition; and positive regulation of cholangiocyte proliferation. Predicted to act upstream of or within cell division. Located in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; central nervous system; gonad; gut; and thymus. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease; cervical cancer; prostate cancer; and urinary bladder cancer. Orthologous to human CDC25A (cell division cycle 25A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 11.3), testis adult (RPKM 10.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.81 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (109704545..109722963)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (109875518..109893895)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25Adagger.
Title: CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25A†.
Our results identify Cdc25A as a potential target for neuroprotectant strategy for the treatment of delayed ischemic neuronal death.
Title: Cdc25A Is a Critical Mediator of Ischemic Neuronal Death In Vitro and In Vivo.
CDC25A-deficient embryonic stem cells resist high doses of ATR inhibitors, which we show is due to their failure to prematurely enter mitosis in response to the drugs.
Title: A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors.
These results showed that IGF1 regulated the expression of BOULE and CDC25A mRNAs via ERK1/2 signaling and in T-independent pathway during spermatogenesis in the adult mouse testes.
Title: IGF1 regulation of BOULE and CDC25A transcripts via a testosterone-independent pathway in spermatogenesis of adult mice.
accelerated cholangiocyte cystogenesis is likely due to overexpression of Cdc25A
Title: Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression.
Cdc25A activity is required for the metaphase II arrest in mouse oocytes.
Title: Cdc25A activity is required for the metaphase II arrest in mouse oocytes.
deletion of Cdc25a increased apoptosis and accelerated the elimination of DNA damage following UV
Title: Accelerated elimination of ultraviolet-induced DNA damage through apoptosis in CDC25A-deficient skin.
In the DNA damage response, instead of inhibiting cyclin B-CDK1 through destruction of Cdc25A phosphatase, oocytes utilize an inhibitory phosphorylation of Cdc25B.
Title: Oocytes progress beyond prophase in the presence of DNA damage.
Cdc25A inhibitors block cell-cycle progression and proliferation, reduce liver and kidney weights and cyst growth in animal models of polycystic kidney/liver disease.
Title: Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease.
CDC25A and CDC25B but not CDC25C compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells
Title: Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Cdc25a gene: The Cdc25a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 336 organisms have orthologs with human gene Cdc25a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholangiocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to radiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: M-phase inducer phosphatase 1

Names: dual specificity phosphatase Cdc25A

NP_031684.3

EC 3.1.3.48

XP_006511992.1

EC 3.1.3.48

XP_006511993.1

EC 3.1.3.48

XP_006511994.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410385.1 → NP_001397314.1 M-phase inducer phosphatase 1 isoform 2

Status: VALIDATED

Source sequence(s)

CT573087
NM_001410386.1 → NP_001397315.1 M-phase inducer phosphatase 1 isoform 3

Status: VALIDATED

Source sequence(s)

CT573087
NM_001410387.1 → NP_001397316.1 M-phase inducer phosphatase 1 isoform 4

Status: VALIDATED

Source sequence(s)

CT573087
NM_001410388.1 → NP_001397317.1 M-phase inducer phosphatase 1 isoform 5

Status: VALIDATED

Source sequence(s)

CT573087
NM_001410389.1 → NP_001397318.1 M-phase inducer phosphatase 1 isoform 5

Status: VALIDATED

Source sequence(s)

CT573087
NM_007658.4 → NP_031684.3 M-phase inducer phosphatase 1 isoform 1

See identical proteins and their annotated locations for NP_031684.3

Status: VALIDATED

Source sequence(s)

CT573087

Consensus CDS

CCDS23559.1

UniProtKB/Swiss-Prot

E9PVD0, P48964

Related

ENSMUSP00000091882.4, ENSMUST00000094324.8

Conserved Domains (2) summary

cd01530
Location:347 → 464

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:85 → 318

M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

109704545..109722963

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511929.5 → XP_006511992.1 M-phase inducer phosphatase 1 isoform X1

Conserved Domains (2) summary

cd01530
Location:355 → 472

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:85 → 326

M-inducer_phosp; M-phase inducer phosphatase
XM_006511930.5 → XP_006511993.1 M-phase inducer phosphatase 1 isoform X2

Conserved Domains (2) summary

cd01530
Location:354 → 471

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:85 → 325

M-inducer_phosp; M-phase inducer phosphatase
XM_006511931.5 → XP_006511994.1 M-phase inducer phosphatase 1 isoform X3

Conserved Domains (2) summary

cd01530
Location:346 → 463

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:85 → 317

M-inducer_phosp; M-phase inducer phosphatase