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Cdc25a cell division cycle 25A [ Mus musculus (house mouse) ]

Gene ID: 12530, updated on 6-Jun-2024

Summary

Official Symbol
Cdc25aprovided by MGI
Official Full Name
cell division cycle 25Aprovided by MGI
Primary source
MGI:MGI:103198
See related
Ensembl:ENSMUSG00000032477 AllianceGenome:MGI:103198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D9Ertd393e
Summary
Predicted to enable chaperone binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including mitotic cell cycle phase transition; positive regulation of cell cycle G2/M phase transition; and positive regulation of cholangiocyte proliferation. Predicted to act upstream of or within cell division. Located in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; central nervous system; gonad; gut; and thymus. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease; cervical cancer; prostate cancer; and urinary bladder cancer. Orthologous to human CDC25A (cell division cycle 25A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.3), testis adult (RPKM 10.4) and 27 other tissues See more
Orthologs
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Genomic context

See Cdc25a in Genome Data Viewer
Location:
9 F2; 9 59.81 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109704545..109722963)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109875518..109893895)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9775 Neighboring gene STARR-seq mESC enhancer starr_25239 Neighboring gene cathelicidin antimicrobial peptide Neighboring gene STARR-positive B cell enhancer ABC_E31 Neighboring gene predicted gene, 39427 Neighboring gene microRNA 7089 Neighboring gene STARR-seq mESC enhancer starr_25247 Neighboring gene STARR-seq mESC enhancer starr_25250 Neighboring gene STARR-positive B cell enhancer ABC_E9336 Neighboring gene predicted gene 4644 Neighboring gene microtubule-associated protein 4 Neighboring gene 60S ribosomal protein L7 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
M-phase inducer phosphatase 1
Names
dual specificity phosphatase Cdc25A
NP_001397314.1
NP_001397315.1
NP_001397316.1
NP_001397317.1
NP_001397318.1
NP_031684.3
XP_006511993.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410385.1NP_001397314.1  M-phase inducer phosphatase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT573087
    UniProtKB/TrEMBL
    Q80VD9
  2. NM_001410386.1NP_001397315.1  M-phase inducer phosphatase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT573087
    UniProtKB/TrEMBL
    Q80VD9
  3. NM_001410387.1NP_001397316.1  M-phase inducer phosphatase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT573087
    UniProtKB/TrEMBL
    Q80VD9
  4. NM_001410388.1NP_001397317.1  M-phase inducer phosphatase 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT573087
  5. NM_001410389.1NP_001397318.1  M-phase inducer phosphatase 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT573087
  6. NM_007658.4NP_031684.3  M-phase inducer phosphatase 1 isoform 1

    See identical proteins and their annotated locations for NP_031684.3

    Status: VALIDATED

    Source sequence(s)
    CT573087
    Consensus CDS
    CCDS23559.1
    UniProtKB/Swiss-Prot
    E9PVD0, P48964
    UniProtKB/TrEMBL
    Q80VD9
    Related
    ENSMUSP00000091882.4, ENSMUST00000094324.8
    Conserved Domains (2) summary
    cd01530
    Location:347464
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:85318
    M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    109704545..109722963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511930.5XP_006511993.1  M-phase inducer phosphatase 1 isoform X2

    UniProtKB/TrEMBL
    Q80VD9
    Conserved Domains (2) summary
    cd01530
    Location:354471
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:85325
    M-inducer_phosp; M-phase inducer phosphatase