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CDC20 cell division cycle 20 [ Homo sapiens (human) ]

Gene ID: 991, updated on 9-Jun-2020

Summary

Official Symbol
CDC20provided by HGNC
Official Full Name
cell division cycle 20provided by HGNC
Primary source
HGNC:HGNC:1723
See related
Ensembl:ENSG00000117399 MIM:603618
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC20A; p55CDC; bA276H19.3
Summary
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 26.5), bone marrow (RPKM 19.7) and 12 other tissues See more
Orthologs

Genomic context

See CDC20 in Genome Data Viewer
Location:
1p34.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (43358981..43363203)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43824626..43828874)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MPL proto-oncogene, thrombopoietin receptor Neighboring gene uncharacterized LOC105378687 Neighboring gene ELOVL fatty acid elongase 1 Neighboring gene microRNA 6734 Neighboring gene uncharacterized LOC112268225

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of cell division cycle 20 (CDC20) in immature dendritic cells and monocyte-derived macrophages PubMed
tat The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102824

Gene Ontology Provided by GOA

Function Evidence Code Pubs
anaphase-promoting complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin ligase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle assembly IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle assembly checkpoint TAS
Traceable Author Statement
more info
 
positive regulation of anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
 
regulation of meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
colocalizes_with anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
spindle TAS
Traceable Author Statement
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cell division cycle protein 20 homolog
Names
CDC20 cell division cycle 20 homolog
cell division cycle 20 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001255.3NP_001246.2  cell division cycle protein 20 homolog

    See identical proteins and their annotated locations for NP_001246.2

    Status: REVIEWED

    Source sequence(s)
    BC001088
    Consensus CDS
    CCDS484.1
    UniProtKB/Swiss-Prot
    Q12834
    Related
    ENSP00000308450.5, ENST00000310955.11
    Conserved Domains (2) summary
    cd00200
    Location:190471
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:229266
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    43358981..43363203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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