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Cdc20 cell division cycle 20 [ Mus musculus (house mouse) ]

Gene ID: 107995, updated on 20-Feb-2024

Summary

Official Symbol
Cdc20provided by MGI
Official Full Name
cell division cycle 20provided by MGI
Primary source
MGI:MGI:1859866
See related
Ensembl:ENSMUSG00000006398 AllianceGenome:MGI:1859866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p55CDC; 2310042N09Rik
Summary
Predicted to enable several functions, including anaphase-promoting complex binding activity; histone deacetylase binding activity; and protein C-terminus binding activity. Involved in positive regulation of synapse maturation and positive regulation of synaptic plasticity. Acts upstream of or within mitotic sister chromatid cohesion; mitotic spindle assembly; and regulation of meiotic nuclear division. Predicted to be located in several cellular components, including centrosome; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of anaphase-promoting complex. Is expressed in several structures, including brain; early conceptus; female reproductive system; hemolymphoid system; and trigeminal ganglion. Orthologous to human CDC20 (cell division cycle 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 69.5), liver E14 (RPKM 66.0) and 17 other tissues See more
Orthologs
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Genomic context

See Cdc20 in Genome Data Viewer
Location:
4 D2.1; 4 54.61 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (118290098..118294540, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (118432901..118437343, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene hydroxypyruvate isomerase (putative) Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene STARR-positive B cell enhancer ABC_E1281 Neighboring gene mediator complex subunit 8 Neighboring gene STARR-positive B cell enhancer ABC_E6202 Neighboring gene ELOVL fatty acid elongase 1 Neighboring gene myeloproliferative leukemia virus oncogene Neighboring gene tyrosine kinase with immunoglobulin-like and EGF-like domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anaphase-promoting complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables anaphase-promoting complex binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in metaphase/anaphase transition of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in metaphase/anaphase transition of meiosis I IDA
Inferred from Direct Assay
more info
PubMed 
involved_in metaphase/anaphase transition of meiosis I ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic metaphase IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synaptic plasticity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of meiotic nuclear division IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitotic checkpoint complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cell division cycle protein 20 homolog
Names
cell division cycle 20 homolog
mmCdc20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023223.2NP_075712.2  cell division cycle protein 20 homolog

    See identical proteins and their annotated locations for NP_075712.2

    Status: VALIDATED

    Source sequence(s)
    AK168650, AV499208, BY736811
    Consensus CDS
    CCDS18551.1
    UniProtKB/Swiss-Prot
    Q3TGP1, Q8BPG4, Q99LK3, Q9JJ66
    Related
    ENSMUSP00000006565.7, ENSMUST00000006565.13
    Conserved Domains (3) summary
    COG2319
    Location:183473
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:190471
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:229266
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    118290098..118294540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)