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MRC2 mannose receptor C-type 2 [ Homo sapiens (human) ]

Gene ID: 9902, updated on 17-Sep-2024

Summary

Official Symbol
MRC2provided by HGNC
Official Full Name
mannose receptor C-type 2provided by HGNC
Primary source
HGNC:HGNC:16875
See related
Ensembl:ENSG00000011028 MIM:612264; AllianceGenome:HGNC:16875
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD280; UPARAP; CLEC13E; ENDO180
Summary
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in gall bladder (RPKM 26.1), ovary (RPKM 24.7) and 24 other tissues See more
Orthologs
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Genomic context

See MRC2 in Genome Data Viewer
Location:
17q23.2
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62627670..62693597)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63497612..63563512)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60705031..60770958)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541227-60541728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60541729-60542228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8807 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8808 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:60562255-60562754 Neighboring gene MPRA-validated peak2934 silencer Neighboring gene tousled like kinase 2 Neighboring gene ribosomal protein S10 pseudogene 26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:60622822-60623322 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60636816-60637174 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:60642433-60643632 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60645420-60645891 Neighboring gene MPRA-validated peak2935 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60696223-60696734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60702756-60703256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60703257-60703757 Neighboring gene uncharacterized LOC107985020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60707912-60708768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729214-60729925 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729926-60730636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60731349-60732059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60743431-60744021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60746820-60747579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60747580-60748338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60748658-60749158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60749159-60749659 Neighboring gene Sharpr-MPRA regulatory region 5505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60757143-60757871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60769301-60769962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60769963-60770624 Neighboring gene RNA, U6 small nuclear 446, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8811 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60781806-60782032 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:60782895-60783686 Neighboring gene uncharacterized LOC105371855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12542 Neighboring gene membrane associated ring-CH-type finger 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12543 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:60817295-60817950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60827154-60827763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60827764-60828372 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:60839055-60839580 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60839581-60840107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8813 Neighboring gene MARCHF10 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60902506-60903242

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binds to mannose receptor on vaginal epithelial cells PubMed
env Mannose receptor (MR) dimers bind to soluble monomeric and trimeric HIV envelope and to HIV virion in capture assay PubMed
env Recombinant HIV-1 gp120 blocks Mannose Receptor-mediated phagocytosis in human and murine macrophages and microglial cells PubMed
env HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin PubMed
env HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes PubMed
Tat tat HIV-1 Tat represses transcription from the rat mannose receptor promoter, thereby downregulating expression of mannose receptor PubMed
tat HIV-1 Tat interaction with cyclin T1 is required for the repression of mannose receptor (MR) and bone morphogenetic protein receptor-2 (BMPR2) promoters PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ35911, KIAA0709

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in collagen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoblast differentiation HDA PubMed 

General protein information

Preferred Names
C-type mannose receptor 2
Names
C-type lectin domain family 13 member E
UPAR-associated protein
endocytic receptor (macrophage mannose receptor family)
endocytic receptor 180
macrophage mannose receptor 2
urokinase-type plasminogen activator receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033955.1 RefSeqGene

    Range
    5270..71197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006039.5NP_006030.2  C-type mannose receptor 2 precursor

    See identical proteins and their annotated locations for NP_006030.2

    Status: REVIEWED

    Source sequence(s)
    AI458446, BC032763, BC146647, BC153884
    Consensus CDS
    CCDS11634.1
    UniProtKB/Swiss-Prot
    A6H8K4, D3DU08, Q7LGE7, Q9UBG0, Q9Y5P9
    Related
    ENSP00000307513.5, ENST00000303375.10
    Conserved Domains (5) summary
    smart00059
    Location:180228
    FN2; Fibronectin type 2 domain
    cd00037
    Location:247361
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:382505
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:46161
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:43127
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    62627670..62693597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437208.1XP_047293164.1  C-type mannose receptor 2 isoform X2

  2. XM_011525543.2XP_011523845.1  C-type mannose receptor 2 isoform X1

    Conserved Domains (5) summary
    smart00059
    Location:180228
    FN2; Fibronectin type 2 domain
    cd00037
    Location:247361
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:382505
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:46161
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:43127
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    63497612..63563512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318061.1XP_054174036.1  C-type mannose receptor 2 isoform X2

  2. XM_054318060.1XP_054174035.1  C-type mannose receptor 2 isoform X1