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NUAK1 NUAK family kinase 1 [ Homo sapiens (human) ]

Gene ID: 9891, updated on 17-Jun-2024

Summary

Official Symbol
NUAK1provided by HGNC
Official Full Name
NUAK family kinase 1provided by HGNC
Primary source
HGNC:HGNC:14311
See related
Ensembl:ENSG00000074590 MIM:608130; AllianceGenome:HGNC:14311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARK5
Summary
Enables p53 binding activity and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of cellular senescence; and regulation of myosin-light-chain-phosphatase activity. Located in cytoplasm; microtubule cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 19.6), skin (RPKM 9.2) and 19 other tissues See more
Orthologs
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Genomic context

See NUAK1 in Genome Data Viewer
Location:
12q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (106063345..106138954, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (106026098..106101716, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (106457123..106532732, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6943 Neighboring gene uncharacterized LOC105369960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6944 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:106254933-106255434 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:106289604-106290350 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:106290351-106291097 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:106291098-106291844 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:106328523-106329722 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:106348645-106349844 Neighboring gene ST13, Hsp70 interacting protein pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106474669-106475169 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:106492406-106492991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106494441-106494974 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106500655-106501400 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106501401-106502144 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106502145-106502889 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106508970-106509546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106509547-106510123 Neighboring gene uncharacterized LOC124903007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106523693-106524442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106524443-106525192 Neighboring gene Sharpr-MPRA regulatory region 11062 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:106526214-106527056 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106527057-106527900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106527901-106528743 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:106531161-106531662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:106534054-106534673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106541977-106542476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106581756-106582590 Neighboring gene thyroid hormone receptor interactor 11 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106605939-106606439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4814 Neighboring gene cytoskeleton associated protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
EBI GWAS Catalog
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0537

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NUAK family SNF1-like kinase 1
Names
AMP-activated protein kinase family member 5
AMPK-related protein kinase 5
NUAK family, SNF1-like kinase, 1
omphalocele kinase 1
NP_055655.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014840.3NP_055655.1  NUAK family SNF1-like kinase 1

    See identical proteins and their annotated locations for NP_055655.1

    Status: VALIDATED

    Source sequence(s)
    AB011109, AC011595, AK027302, BG831390, BQ694341, CK001516, R61142
    Consensus CDS
    CCDS31892.1
    UniProtKB/Swiss-Prot
    A7MD39, O60285, Q96KA8
    Related
    ENSP00000261402.2, ENST00000261402.7
    Conserved Domains (2) summary
    smart00220
    Location:55306
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14073
    Location:53306
    STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    106063345..106138954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    106026098..106101716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)