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Nuak1 NUAK family, SNF1-like kinase, 1 [ Mus musculus (house mouse) ]

Gene ID: 77976, updated on 21-Apr-2024

Summary

Official Symbol
Nuak1provided by MGI
Official Full Name
NUAK family, SNF1-like kinase, 1provided by MGI
Primary source
MGI:MGI:1925226
See related
Ensembl:ENSMUSG00000020032 AllianceGenome:MGI:1925226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Omphk1; B230104P22Rik
Summary
Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; regulation of cellular senescence; and regulation of myosin-light-chain-phosphatase activity. Predicted to act upstream of or within cell adhesion; cellular response to DNA damage stimulus; and phosphorylation. Predicted to be located in fibrillar center; microtubule cytoskeleton; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; embryo ectoderm; nervous system; nose; and urinary system. Orthologous to human NUAK1 (NUAK family kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 10.9), CNS E18 (RPKM 10.8) and 24 other tissues See more
Orthologs
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Genomic context

Location:
10 C1; 10 41.42 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (84206764..84282028, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (84370900..84440668, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5425 Neighboring gene predicted gene, 46201 Neighboring gene RIKEN cDNA 4930463O16 gene Neighboring gene predicted gene, 34405 Neighboring gene transcription factor E3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90816

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NUAK family SNF1-like kinase 1
Names
AMPK-related protein kinase 5
ZNUAK family, SNF1-like kinase, 1
omphalocele kinase 1
NP_001004363.1
XP_011241905.1
XP_036011997.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004363.2NP_001004363.1  NUAK family SNF1-like kinase 1

    See identical proteins and their annotated locations for NP_001004363.1

    Status: VALIDATED

    Source sequence(s)
    AC150314, AI450794, BB808457, BC082328, CF534664, CJ106400, CJ247195
    Consensus CDS
    CCDS24079.1
    UniProtKB/Swiss-Prot
    Q641K5, Q6I6D6, Q8CGE1
    Related
    ENSMUSP00000020220.9, ENSMUST00000020220.15
    Conserved Domains (2) summary
    smart00220
    Location:56307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14073
    Location:54307
    STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    84206764..84282028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156104.1XP_036011997.1  NUAK family SNF1-like kinase 1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1210
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011243603.4XP_011241905.1  NUAK family SNF1-like kinase 1 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1175
    PKc_like; Protein Kinases, catalytic domain