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ZNF518A zinc finger protein 518A [ Homo sapiens (human) ]

Gene ID: 9849, updated on 11-Jun-2021

Summary

Official Symbol
ZNF518Aprovided by HGNC
Official Full Name
zinc finger protein 518Aprovided by HGNC
Primary source
HGNC:HGNC:29009
See related
Ensembl:ENSG00000177853 MIM:617733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF518
Summary
The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Numerous transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2016]
Expression
Broad expression in testis (RPKM 8.9), colon (RPKM 3.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF518A in Genome Data Viewer
Location:
10q24.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (96128906..96205291)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (97889472..97965047)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ENTPD1 antisense RNA 1 Neighboring gene microRNA 3157 Neighboring gene RNA, U6 small nuclear 271, pseudogene Neighboring gene nucleophosmin 1 pseudogene 25 Neighboring gene B cell linker Neighboring gene DNA nucleotidylexotransferase Neighboring gene oligodendrocytic myelin paranodal and inner loop protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 518A (ZNF518A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125707, MGC125710, DKFZp781O2147

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 518A
Names
zinc finger protein 518

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033267.2 RefSeqGene

    Range
    5496..39540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278524.2NP_001265453.1  zinc finger protein 518A isoform a

    See identical proteins and their annotated locations for NP_001265453.1

    Status: REVIEWED

    Source sequence(s)
    AC021037, FO082045
    Consensus CDS
    CCDS73170.1
    UniProtKB/Swiss-Prot
    Q6AHZ1
    Related
    ENSP00000481657.1, ENST00000614149.1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001278525.2NP_001265454.1  zinc finger protein 518A isoform a

    See identical proteins and their annotated locations for NP_001265454.1

    Status: REVIEWED

    Source sequence(s)
    AB002333, AC021037, AW514026, BC030967, FO082045
    Consensus CDS
    CCDS73170.1
    UniProtKB/Swiss-Prot
    Q6AHZ1
    Related
    ENSP00000485614.1, ENST00000624776.3
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001278526.2NP_001265455.1  zinc finger protein 518A isoform b

    See identical proteins and their annotated locations for NP_001265455.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) uses a downstream start codon compared to isoform a. It encodes isoform b which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC021037, AW514026, BC109045
    UniProtKB/Swiss-Prot
    Q6AHZ1
  4. NM_001330732.2NP_001317661.1  zinc finger protein 518A isoform a

    Status: REVIEWED

    Source sequence(s)
    AC021037, FO082045
    Consensus CDS
    CCDS73170.1
    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001330733.1NP_001317662.1  zinc finger protein 518A isoform a

    Status: REVIEWED

    Source sequence(s)
    AC021037, FO082045
    Consensus CDS
    CCDS73170.1
    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001330734.1NP_001317663.1  zinc finger protein 518A isoform a

    Status: REVIEWED

    Source sequence(s)
    AC021037, FO082045
    Consensus CDS
    CCDS73170.1
    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001330735.1NP_001317664.1  zinc finger protein 518A isoform a

    Status: REVIEWED

    Source sequence(s)
    AC021037, FO082045
    Consensus CDS
    CCDS73170.1
    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001330736.2NP_001317665.1  zinc finger protein 518A isoform a

    Status: REVIEWED

    Source sequence(s)
    AC021037, FO082045
    Consensus CDS
    CCDS73170.1
    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_001330737.1NP_001317666.1  zinc finger protein 518A isoform a

    Status: REVIEWED

    Source sequence(s)
    AC021037, FO082045
    Consensus CDS
    CCDS73170.1
    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. NM_001330738.1NP_001317667.1  zinc finger protein 518A isoform a

    Status: REVIEWED

    Source sequence(s)
    AC021037, FO082045
    Consensus CDS
    CCDS73170.1
    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. NM_014803.4NP_055618.2  zinc finger protein 518A isoform a

    See identical proteins and their annotated locations for NP_055618.2

    Status: REVIEWED

    Source sequence(s)
    AC021037, CR627437
    Consensus CDS
    CCDS73170.1
    UniProtKB/Swiss-Prot
    Q6AHZ1
    Related
    ENSP00000479684.1, ENST00000316045.9
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_138482.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 3' exon structure compared to variant 1. This variant is represented as non-coding because it lacks the entire open reading frame found in variant 1.
    Source sequence(s)
    AC021037

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    96128906..96205291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448266.1XP_024304034.1  zinc finger protein 518A isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_011540413.3XP_011538715.1  zinc finger protein 518A isoform X1

    See identical proteins and their annotated locations for XP_011538715.1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_017016994.2XP_016872483.1  zinc finger protein 518A isoform X1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_024448269.1XP_024304037.1  zinc finger protein 518A isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_011540415.2XP_011538717.1  zinc finger protein 518A isoform X1

    See identical proteins and their annotated locations for XP_011538717.1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_024448265.1XP_024304033.1  zinc finger protein 518A isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_017016989.1XP_016872478.1  zinc finger protein 518A isoform X1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_011540420.2XP_011538722.1  zinc finger protein 518A isoform X1

    See identical proteins and their annotated locations for XP_011538722.1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_011540418.2XP_011538720.1  zinc finger protein 518A isoform X1

    See identical proteins and their annotated locations for XP_011538720.1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_011540410.2XP_011538712.1  zinc finger protein 518A isoform X1

    See identical proteins and their annotated locations for XP_011538712.1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. XM_011540406.2XP_011538708.1  zinc finger protein 518A isoform X1

    See identical proteins and their annotated locations for XP_011538708.1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. XM_011540419.2XP_011538721.1  zinc finger protein 518A isoform X1

    See identical proteins and their annotated locations for XP_011538721.1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  13. XM_011540412.2XP_011538714.1  zinc finger protein 518A isoform X1

    See identical proteins and their annotated locations for XP_011538714.1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. XM_024448267.1XP_024304035.1  zinc finger protein 518A isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  15. XM_024448268.1XP_024304036.1  zinc finger protein 518A isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  16. XM_017016986.1XP_016872475.1  zinc finger protein 518A isoform X1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  17. XM_017016992.1XP_016872481.1  zinc finger protein 518A isoform X1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  18. XM_017016998.1XP_016872487.1  zinc finger protein 518A isoform X1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  19. XM_017016999.1XP_016872488.1  zinc finger protein 518A isoform X1

    UniProtKB/Swiss-Prot
    Q6AHZ1
    Conserved Domains (1) summary
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
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