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ZNF623 zinc finger protein 623 [ Homo sapiens (human) ]

Gene ID: 9831, updated on 21-Dec-2019

Summary

Official Symbol
ZNF623provided by HGNC
Official Full Name
zinc finger protein 623provided by HGNC
Primary source
HGNC:HGNC:29084
See related
Ensembl:ENSG00000183309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in ovary (RPKM 5.7), thyroid (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See ZNF623 in Genome Data Viewer
Location:
8q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (143636019..143653730)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144718183..144735900)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375798 Neighboring gene tissue specific transplantation antigen P35B Neighboring gene uncharacterized LOC105375799 Neighboring gene zinc finger protein 707

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC103965, MGC104128

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082480.2NP_001075949.1  zinc finger protein 623 isoform 2

    See identical proteins and their annotated locations for NP_001075949.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB014528, BC112898
    Consensus CDS
    CCDS47931.1
    UniProtKB/Swiss-Prot
    O75123
    UniProtKB/TrEMBL
    A0A0A0MT18
    Related
    ENSP00000411139.2, ENST00000458270.2
    Conserved Domains (4) summary
    COG5048
    Location:83454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251273
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:210234
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001261843.2NP_001248772.1  zinc finger protein 623 isoform 2

    See identical proteins and their annotated locations for NP_001248772.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB014528, AK294695, DC355766, DC380463
    Consensus CDS
    CCDS47931.1
    UniProtKB/Swiss-Prot
    O75123
    UniProtKB/TrEMBL
    A0A0A0MT18
    Related
    ENSP00000435232.1, ENST00000526926.5
    Conserved Domains (4) summary
    COG5048
    Location:83454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251273
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:210234
    zf-H2C2_2; Zinc-finger double domain
  3. NM_014789.3NP_055604.3  zinc finger protein 623 isoform 1

    See identical proteins and their annotated locations for NP_055604.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC067516, BC067517, BX477157, DA100931, DA211779, DB161675, DB227885
    Consensus CDS
    CCDS34957.1
    UniProtKB/Swiss-Prot
    O75123
    UniProtKB/TrEMBL
    A0A0J9YW98
    Related
    ENSP00000445979.1, ENST00000501748.3
    Conserved Domains (4) summary
    COG5048
    Location:123494
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293313
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:291313
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:250274
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    143636019..143653730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716708.3XP_006716771.1  zinc finger protein 623 isoform X1

    See identical proteins and their annotated locations for XP_006716771.1

    UniProtKB/TrEMBL
    A0A0A0MT18
    Conserved Domains (4) summary
    COG5048
    Location:83454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251273
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:210234
    zf-H2C2_2; Zinc-finger double domain

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    111849..129199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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