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KEAP1 kelch like ECH associated protein 1 [ Homo sapiens (human) ]

Gene ID: 9817, updated on 6-Oct-2024

Summary

Official Symbol
KEAP1provided by HGNC
Official Full Name
kelch like ECH associated protein 1provided by HGNC
Primary source
HGNC:HGNC:23177
See related
Ensembl:ENSG00000079999 MIM:606016; AllianceGenome:HGNC:23177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INrf2; KLHL19
Summary
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 10.4), prostate (RPKM 9.9) and 25 other tissues See more
Orthologs
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Genomic context

See KEAP1 in Genome Data Viewer
Location:
19p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10486125..10503356, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10612569..10629791, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10596801..10614032, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10067 Neighboring gene cell division cycle 37, HSP90 cochaperone Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13966 Neighboring gene microRNA 1181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13967 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10527911-10528462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10528463-10529013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10530007-10530886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10542553-10543236 Neighboring gene phosphodiesterase 4A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10543237-10543919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10546465-10546964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10572008-10572732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10602595-10603095 Neighboring gene Sharpr-MPRA regulatory region 8442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10612744-10613299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10625413-10626006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10626007-10626600 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10629468-10630030 Neighboring gene sphingosine-1-phosphate receptor 5 Neighboring gene MPRA-validated peak3353 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10079 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10080 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10081 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10654971-10655566 Neighboring gene RNA, U7 small nuclear 140 pseudogene Neighboring gene autophagy related 4D cysteine peptidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Overexpression of Nrf2 or Keap1 knockdown by siRNA inhibits Tat-induced HIV-1 LTR transactivation in MAGI cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC1114, MGC4407, MGC9454, KIAA0132, MGC10630, MGC20887

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin filament IEA
Inferred from Electronic Annotation
more info
 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
kelch-like ECH-associated protein 1
Names
KEAP1 delta C
cytosolic inhibitor of Nrf2
kelch-like family member 19
kelch-like protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012289.4NP_036421.2  kelch-like ECH-associated protein 1

    See identical proteins and their annotated locations for NP_036421.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AU130822, BC002930
    Consensus CDS
    CCDS12239.1
    UniProtKB/Swiss-Prot
    B3KPD5, Q14145, Q6LEP0, Q8WTX1, Q9BPY9
    Related
    ENSP00000377245.1, ENST00000393623.6
    Conserved Domains (3) summary
    PHA03098
    Location:95596
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:460503
    Kelch; KELCH repeat [structural motif]
    cd18248
    Location:56180
    BTB_POZ_KLHL19_KEAP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1)
  2. NM_203500.2NP_987096.1  kelch-like ECH-associated protein 1

    See identical proteins and their annotated locations for NP_987096.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AK056204, BC015945
    Consensus CDS
    CCDS12239.1
    UniProtKB/Swiss-Prot
    B3KPD5, Q14145, Q6LEP0, Q8WTX1, Q9BPY9
    Related
    ENSP00000171111.4, ENST00000171111.10
    Conserved Domains (3) summary
    PHA03098
    Location:95596
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:460503
    Kelch; KELCH repeat [structural motif]
    cd18248
    Location:56180
    BTB_POZ_KLHL19_KEAP1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    10486125..10503356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    10612569..10629791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)