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Keap1 kelch-like ECH-associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 50868, updated on 2-Nov-2024

Summary

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Official Symbol
Keap1provided by MGI
Official Full Name
kelch-like ECH-associated protein 1provided by MGI
Primary source
MGI:MGI:1858732
See related
Ensembl:ENSMUSG00000003308 AllianceGenome:MGI:1858732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
INRF2; mKIAA0132
Summary
Enables disordered domain specific binding activity and identical protein binding activity. Involved in several processes, including cellular response to oxidative stress; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including cellular response to interleukin-4; in utero embryonic development; and regulation of epidermal cell differentiation. Located in actin filament; endoplasmic reticulum; and inclusion body. Part of Cul3-RING ubiquitin ligase complex. Is expressed in eye and limb mesenchyme. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 41.2), adrenal adult (RPKM 36.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Keap1 in Genome Data Viewer
Location:
9 A3; 9 7.74 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21141026..21150628, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21229730..21239332, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36118 Neighboring gene predicted gene, 35977 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:20966019-20966202 Neighboring gene predicted gene, 39301 Neighboring gene phosphodiesterase 4A, cAMP specific Neighboring gene STARR-positive B cell enhancer ABC_E1781 Neighboring gene STARR-seq mESC enhancer starr_23485 Neighboring gene predicted gene, 16754 Neighboring gene STARR-seq mESC enhancer starr_23486 Neighboring gene STARR-positive B cell enhancer ABC_E8278 Neighboring gene sphingosine-1-phosphate receptor 5 Neighboring gene STARR-positive B cell enhancer mm9_chr9:21069491-21069792 Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Keap1 signaling in the regulation of HSP90 pathway. Bonura A, et al. Cell Stress Chaperones, 2022 May. PMID 35362892, Free PMC Article
  2. KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy. Shekh-Ahmad T, et al. Brain, 2018 May 1. PMID 29538645
  3. Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding. More VR, et al. Free Radic Biol Med, 2013 Aug. PMID 23507082, Free PMC Article
  4. Exploring the target scope of KEAP1 E3 ligase-based PROTACs. Du G, et al. Cell Chem Biol, 2022 Oct 20. PMID 36070758, Free PMC Article
  5. Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation. Kim S, et al. PLoS One, 2014. PMID 24489685, Free PMC Article

See all (312) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Homocysteine-potentiated Kelch-like ECH-associated protein 1 promotes senescence of neuroblastoma 2a cells via inhibiting ubiquitination of beta-catenin.
    Title: Homocysteine-potentiated Kelch-like ECH-associated protein 1 promotes senescence of neuroblastoma 2a cells via inhibiting ubiquitination of β-catenin.
  2. Dual Deletion of Keap1 and Rbpjkappa Genes in Liver Leads to Hepatomegaly and Hypercholesterolemia.
    Title: Dual Deletion of Keap1 and Rbpjκ Genes in Liver Leads to Hepatomegaly and Hypercholesterolemia.
  3. Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2.
    Title: Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2.
  4. GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway.
    Title: GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway.
  5. KEAP1-Mutant Lung Cancers Weaken Anti-Tumor Immunity and Promote an M2-like Macrophage Phenotype.
    Title: KEAP1-Mutant Lung Cancers Weaken Anti-Tumor Immunity and Promote an M2-like Macrophage Phenotype.
  6. Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion.
    Title: Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion.
  7. Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis.
    Title: Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis.
  8. FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
    Title: FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
  9. Nrf2 activation improves experimental rheumatoid arthritis.
    Title: Nrf2 activation improves experimental rheumatoid arthritis.
  10. Dynamic change and preventive role of stress response via Keap1-Nrf2 during renal crystal formation.
    Title: Dynamic change and preventive role of stress response via Keap1-Nrf2 during renal crystal formation.
Submit: New GeneRIF Correction See all GeneRIFs (154)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables disordered domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription regulator inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to carbohydrate stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in inclusion body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like ECH-associated protein 1
Names
NRF2 cytosolic inhibitor
cytosolic inhibitor of Nrf2
ring canal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110305.1 → NP_001103775.1  kelch-like ECH-associated protein 1

    See identical proteins and their annotated locations for NP_001103775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AC163637, AK150485, AK159858, BY586021
    Consensus CDS
    CCDS22897.1
    UniProtKB/Swiss-Prot
    Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
    Related
    ENSMUSP00000062467.5, ENSMUST00000049567.10
    Conserved Domains (5) summary
    smart00612
    Location:471 → 517
    Kelch; Kelch domain
    PHA03098
    Location:95 → 596
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:460 → 503
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:67 → 176
    BTB; BTB/POZ domain
    pfam07707
    Location:184 → 286
    BACK; BTB And C-terminal Kelch

  2. NM_001110306.1 → NP_001103776.1  kelch-like ECH-associated protein 1

    See identical proteins and their annotated locations for NP_001103776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AC163637, AK004738, BY586021, CJ179527
    Consensus CDS
    CCDS22897.1
    UniProtKB/Swiss-Prot
    Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
    Related
    ENSMUSP00000141840.2, ENSMUST00000193982.2
    Conserved Domains (5) summary
    smart00612
    Location:471 → 517
    Kelch; Kelch domain
    PHA03098
    Location:95 → 596
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:460 → 503
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:67 → 176
    BTB; BTB/POZ domain
    pfam07707
    Location:184 → 286
    BACK; BTB And C-terminal Kelch

  3. NM_001110307.1 → NP_001103777.1  kelch-like ECH-associated protein 1

    See identical proteins and their annotated locations for NP_001103777.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AK004738, BY586021
    Consensus CDS
    CCDS22897.1
    UniProtKB/Swiss-Prot
    Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
    Related
    ENSMUSP00000141807.2, ENSMUST00000194542.6
    Conserved Domains (5) summary
    smart00612
    Location:471 → 517
    Kelch; Kelch domain
    PHA03098
    Location:95 → 596
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:460 → 503
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:67 → 176
    BTB; BTB/POZ domain
    pfam07707
    Location:184 → 286
    BACK; BTB And C-terminal Kelch

  4. NM_016679.4 → NP_057888.1  kelch-like ECH-associated protein 1

    See identical proteins and their annotated locations for NP_057888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AC163637, AK076234, BY586021
    Consensus CDS
    CCDS22897.1
    UniProtKB/Swiss-Prot
    Q3U243, Q3U8N7, Q547S3, Q6ZQI6, Q8BQY3, Q9Z2X8
    Related
    ENSMUSP00000131029.2, ENSMUST00000164812.8
    Conserved Domains (5) summary
    smart00612
    Location:471 → 517
    Kelch; Kelch domain
    PHA03098
    Location:95 → 596
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:460 → 503
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:67 → 176
    BTB; BTB/POZ domain
    pfam07707
    Location:184 → 286
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21141026..21150628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2X8.1 GenPept UniProtKB/Swiss-Prot:Q9Z2X8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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