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Keap1 kelch-like ECH-associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 50868, updated on 20-Sep-2022

Summary

Official Symbol
Keap1provided by MGI
Official Full Name
kelch-like ECH-associated protein 1provided by MGI
Primary source
MGI:MGI:1858732
See related
Ensembl:ENSMUSG00000003308 AllianceGenome:MGI:1858732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
INRF2; mKIAA0132
Summary
Enables disordered domain specific binding activity and identical protein binding activity. Involved in cellular protein metabolic process; cellular response to oxidative stress; and regulation of autophagy. Acts upstream of or within several processes, including cellular response to interleukin-4; in utero embryonic development; and regulation of epidermal cell differentiation. Located in actin filament; endoplasmic reticulum; and inclusion body. Part of Cul3-RING ubiquitin ligase complex. Is expressed in eye and limb mesenchyme. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 41.2), adrenal adult (RPKM 36.0) and 28 other tissues See more
Orthologs
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Genomic context

See Keap1 in Genome Data Viewer
Location:
9; 9 A3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21141026..21150628, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21229730..21239332, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (21034174..21043776, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36118 Neighboring gene predicted gene, 35977 Neighboring gene predicted gene, 39301 Neighboring gene phosphodiesterase 4A, cAMP specific Neighboring gene sphingosine-1-phosphate receptor 5 Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to carbohydrate stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic sequestering of transcription factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytoplasmic sequestering of transcription factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kelch-like ECH-associated protein 1
Names
NRF2 cytosolic inhibitor
cytosolic inhibitor of Nrf2
ring canal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110305.1NP_001103775.1  kelch-like ECH-associated protein 1

    See identical proteins and their annotated locations for NP_001103775.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AC163637, AK150485, AK159858, BY586021
    Consensus CDS
    CCDS22897.1
    UniProtKB/Swiss-Prot
    Q8BQY3, Q9Z2X8
    Related
    ENSMUSP00000062467.5, ENSMUST00000049567.10
    Conserved Domains (5) summary
    smart00612
    Location:471517
    Kelch; Kelch domain
    PHA03098
    Location:95596
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:460503
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:67176
    BTB; BTB/POZ domain
    pfam07707
    Location:184286
    BACK; BTB And C-terminal Kelch
  2. NM_001110306.1NP_001103776.1  kelch-like ECH-associated protein 1

    See identical proteins and their annotated locations for NP_001103776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AC163637, AK004738, BY586021, CJ179527
    Consensus CDS
    CCDS22897.1
    UniProtKB/Swiss-Prot
    Q8BQY3, Q9Z2X8
    Related
    ENSMUSP00000141840.2, ENSMUST00000193982.2
    Conserved Domains (5) summary
    smart00612
    Location:471517
    Kelch; Kelch domain
    PHA03098
    Location:95596
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:460503
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:67176
    BTB; BTB/POZ domain
    pfam07707
    Location:184286
    BACK; BTB And C-terminal Kelch
  3. NM_001110307.1NP_001103777.1  kelch-like ECH-associated protein 1

    See identical proteins and their annotated locations for NP_001103777.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AK004738, BY586021
    Consensus CDS
    CCDS22897.1
    UniProtKB/Swiss-Prot
    Q8BQY3, Q9Z2X8
    Related
    ENSMUSP00000141807.2, ENSMUST00000194542.6
    Conserved Domains (5) summary
    smart00612
    Location:471517
    Kelch; Kelch domain
    PHA03098
    Location:95596
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:460503
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:67176
    BTB; BTB/POZ domain
    pfam07707
    Location:184286
    BACK; BTB And C-terminal Kelch
  4. NM_016679.4NP_057888.1  kelch-like ECH-associated protein 1

    See identical proteins and their annotated locations for NP_057888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AC163637, AK076234, BY586021
    Consensus CDS
    CCDS22897.1
    UniProtKB/Swiss-Prot
    Q8BQY3, Q9Z2X8
    Related
    ENSMUSP00000131029.2, ENSMUST00000164812.8
    Conserved Domains (5) summary
    smart00612
    Location:471517
    Kelch; Kelch domain
    PHA03098
    Location:95596
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:460503
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:67176
    BTB; BTB/POZ domain
    pfam07707
    Location:184286
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21141026..21150628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)