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SPCS2 signal peptidase complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 9789, updated on 5-Sep-2021

Summary

Official Symbol
SPCS2provided by HGNC
Official Full Name
signal peptidase complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:28962
See related
Ensembl:ENSG00000118363 MIM:619411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 48.0), prostate (RPKM 34.0) and 25 other tissues See more
Orthologs
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Genomic context

See SPCS2 in Genome Data Viewer
Location:
11q13.4
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (74949266..74979033)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74660311..74690078)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene X-ray radiation resistance associated 1 Neighboring gene ribosomal protein L31 pseudogene 46 Neighboring gene uncharacterized LOC107984352 Neighboring gene RNA, U6 small nuclear 216, pseudogene Neighboring gene neuraminidase 3 Neighboring gene olfactory receptor family 2 subfamily AT member 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of signal peptidase complex subunit 2 homolog (S. cerevisiae; SPCS2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with signal peptidase complex subunit 2 homolog (SPCS2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ56339, KIAA0102, MGC117366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
signal peptidase complex subunit 2
Names
SPase 25 kDa subunit
microsomal signal peptidase 25 kDa subunit
signal peptidase 25kDa subunit
signal peptidase complex subunit 2 homolog
NP_055567.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014752.3NP_055567.2  signal peptidase complex subunit 2

    See identical proteins and their annotated locations for NP_055567.2

    Status: VALIDATED

    Source sequence(s)
    AA921960, AP001992, BP338843, D14658
    Consensus CDS
    CCDS44681.1
    UniProtKB/Swiss-Prot
    Q15005
    Related
    ENSP00000263672.6, ENST00000263672.11
    Conserved Domains (1) summary
    pfam06703
    Location:61217
    SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    74949266..74979033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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