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Spcs2 signal peptidase complex subunit 2 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 66624, updated on 5-Mar-2024

Summary

Official Symbol
Spcs2provided by MGI
Official Full Name
signal peptidase complex subunit 2 homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1913874
See related
Ensembl:ENSMUSG00000035227 AllianceGenome:MGI:1913874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0102; 5730406I15Rik
Summary
Predicted to enable peptidase activity. Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to act upstream of or within proteolysis. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; brain; integumental system; respiratory system; and urinary system. Orthologous to human SPCS2 (signal peptidase complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 23.9), CNS E11.5 (RPKM 21.2) and 28 other tissues See more
Orthologs
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Genomic context

See Spcs2 in Genome Data Viewer
Location:
7 E1; 7 54.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99486775..99512576, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99837569..99870340, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AT member 1 Neighboring gene olfactory receptor enhancer Ikaria Neighboring gene STARR-positive B cell enhancer ABC_E3735 Neighboring gene STARR-seq mESC enhancer starr_19662 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:106976805-106976914 Neighboring gene STARR-positive B cell enhancer ABC_E3736 Neighboring gene neuraminidase 3 Neighboring gene STARR-positive B cell enhancer ABC_E1347 Neighboring gene X-ray radiation resistance associated 1 Neighboring gene predicted gene, 38405 Neighboring gene ring finger protein 169 Neighboring gene predicted gene 5115

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC60452

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal peptide processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of signal peptidase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal peptidase complex subunit 2
Names
SPase 25 kDa subunit
microsomal signal peptidase 25 kDa subunit
NP_001405668.1
NP_079944.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418739.1NP_001405668.1  signal peptidase complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113298, AC115040
    UniProtKB/TrEMBL
    A0A140LHR3
    Related
    ENSMUSP00000146514.2, ENSMUST00000207063.2
  2. NM_025668.4NP_079944.1  signal peptidase complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_079944.1

    Status: VALIDATED

    Source sequence(s)
    AC113298, AC115040
    Consensus CDS
    CCDS40033.1
    UniProtKB/Swiss-Prot
    Q3THR2, Q80X74, Q921V8, Q9CXK1, Q9CYN2
    UniProtKB/TrEMBL
    A0A140LHG8
    Related
    ENSMUSP00000041152.7, ENSMUST00000036274.8
    Conserved Domains (1) summary
    pfam06703
    Location:61216
    SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    99486775..99512576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)